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Christina Anne Mitchell

Christina Anne Mitchell

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
11681
World Ranking
8005
National Ranking
200

Overview

Christina Anne Mitchell is affiliated with Monash University in Australia. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

The main areas of study for Mitchell include Molecular Biology, Cell Biology, Genetics, Physiology, and Oncology. Their work prominently addresses topics such as PI3K/AKT/mTOR signaling in cancer, cellular transport and secretion mechanisms, protein kinase regulation and GTPase signaling, autophagy in disease and therapy, genetic and kidney cyst diseases, calcium signaling and nucleotide metabolism, as well as coagulation, bradykinin, polyphosphates, and angioedema.

Mitchell has published numerous papers across a variety of scientific journals and venues. Frequent publication venues include:

  • Autophagy
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Advances
  • International Journal of Molecular Sciences

Their recent papers illustrate the scope of research topics and include the following:

  • "Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance" (2021) in Science Advances
  • "Defective lysosome reformation during autophagy causes skeletal muscle disease" (2020) in Journal of Clinical Investigation
  • "Autophagic lysosome reformation in health and disease" (2022) in Autophagy
  • "PTEN and Other PtdIns(3,4,5)P3 Lipid Phosphatases in Breast Cancer" (2020) in International Journal of Molecular Sciences
  • "Caveolae Control Contractile Tension for Epithelia to Eliminate Tumor Cells" (2020) in Developmental Cell

Collaborations are notable with frequent co-authors such as Lisa M. Ooms, Meagan J. McGrath, Samuel J. Rodgers, Rajendra Gurung, and Matthew J. Eramo. These partnerships have contributed to a consistent output of research particularly in molecular and cellular biology.

Best Publications

  • Reactive oxygen species enhance insulin sensitivity.

    Kim Yong Loh;Haiyang Deng;Atsushi Fukushima;Xiaochu Cai

  • Sec15 is an effector for the Rab11 GTPase in mammalian cells

    Xiang-Ming Zhang;Sarah L Ellis;Absorn Sriratana;Christina Anne Mitchell

  • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

    Clare G Fedele;Lisa M Ooms;Miriel Ho;Jessica L Vieusseux

  • Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays.

    Jiacheng Yang;Christine Moravec;Christine Moravec;Mark A Sussman;Nicholas R Dipaola

  • The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

    Lisa Michelle Ooms;Kristy Amanda Horan;Parvin Rahman;Gillian Seaton

  • Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

    Prasad Cooray;Yuping Yuan;Simone M Schoenwaelder;Christina A Mitchell

  • The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

    Jennifer M Dyson;Cindy Joy O'Malley;Jelena Becanovic;Adam D Munday

  • Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.

    Shaun P. Jackson;Simone M. Schoenwaelder;Yuping Yuan;Ian Rabinowitz

  • Four and a Half LIM Protein 1 Binds Myosin-binding Protein C and Regulates Myosin Filament Formation and Sarcomere Assembly

    Meagan J. McGrath;Denny L. Cottle;Mai-Anh Nguyen;Jennifer M. Dyson

  • Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy

    Joachim Schessl;Yaqun Zou;Meagan Jane Mcgrath;Belinda Simone Cowling

  • Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation.

    Annette C Schmid;Helen M Wise;Christina Anne Mitchell;Robert Nussbaum

  • Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy

    Belinda Simone Cowling;Meagan Jane Mcgrath;Mai-Anh Nguyen;Denny Cottle

  • Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1. Localization of SLIM1 at focal adhesions and the isoform slimmer in the nucleus of myoblasts and cytoplasm of myotubes suggests distinct roles in the cytoskeleton and in nuclear-cytoplasmic communication.

    Susan Brown;Meagan Jane Mcgrath;Lisa M Ooms;Rajendra Gurung

  • Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

    Bernadette Carroll;Glyn Nelson;Yoana Rabanal-Ruiz;Olena Kucheryavenko

  • The PtdIns(3,4)P 2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

    Junko Sasaki;Satoshi Kofuji;Satoshi Kofuji;Reietsu Itoh;Reietsu Itoh;Toshihiko Momiyama

  • Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex.

    Robert K Andrews;Adam D Munday;Christina Anne Mitchell;Michael C Berndt

  • Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy

    Felix W Friedrich;Brendan R Wilding;Silke Reischmann;Claudia Crocini

  • The Type Iα Inositol Polyphosphate 4-Phosphatase Generates and Terminates Phosphoinositide 3-Kinase Signals on Endosomes and the Plasma Membrane

    Ivan Ivetac;Adam Dallas Munday;Marina V Kisseleva;Xiang-Ming Zhang

  • Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

    Adam D Munday;Michael C Berndt;Christina Anne Mitchell

  • TBC domain family, member 15 is a novel mammalian Rab GTPase-activating protein with substrate preference for Rab7.

    Xiang-Ming Zhang;Bong Walsh;Christina Anne Mitchell;Tony Rowe

Frequent Co-Authors

Catriona McLean
Catriona McLean The Alfred Hospital
Tony Tiganis
Tony Tiganis Peter MacCallum Cancer Centre
Philip W. Majerus
Philip W. Majerus Washington University in St. Louis
Wayne A. Phillips
Wayne A. Phillips Peter MacCallum Cancer Centre
James C. Whisstock
James C. Whisstock Monash University
Shaun P. Jackson
Shaun P. Jackson University of Sydney
John E.J. Rasko
John E.J. Rasko Centenary Institute of Cancer Medicine and Cell Biology
Michael C. Berndt
Michael C. Berndt Curtin University
Simone M. Schoenwaelder
Simone M. Schoenwaelder The Heart Research Institute
Edna C. Hardeman
Edna C. Hardeman University of New South Wales

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