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D-Index & Metrics

Biology and Biochemistry

D-Index
64
Citations
14070
World Ranking
9707
National Ranking
4275

Overview

Xiaoping Du is a researcher affiliated with the University of Illinois at Chicago in the United States. Their work primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with a focus on hematology, immunology, nutrition, and genetics as notable subfields.

The researcher has contributed extensively to topics such as:

  • Cell Adhesion Molecules Research
  • Platelet Disorders and Treatments
  • Blood Disorders and Treatments
  • Selenium in Biological Systems
  • Trace Elements in Health
  • Blood Coagulation and Thrombosis Mechanisms
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Recent publications by Xiaoping Du include:

  • High-loading Gα 13-binding EXE peptide nanoparticles prevent thrombosis and protect mice from cardiac ischemia/reperfusion injury, 2020, Science Translational Medicine
  • Signaling mechanisms of the platelet glycoprotein Ib-IX complex, 2022, Platelets
  • Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation, 2021, Arteriosclerosis Thrombosis and Vascular Biology
  • Selenium concentration is associated with occurrence and diagnosis of three cardiovascular diseases: A systematic review and meta-analysis, 2021, Journal of Trace Elements in Medicine and Biology
  • Targeting Gα13-integrin interaction ameliorates systemic inflammation, 2021, Nature Communications

The frequent co-authors of their work include Yanyan Bai, Ni Cheng, Zengrun Xia, Claire Chang, and Can Wang. These collaborations reflect a network of researchers who have contributed jointly on multiple projects.

Publication venues appearing regularly in their research are:

  • Arteriosclerosis Thrombosis and Vascular Biology
  • Journal of Trace Elements in Medicine and Biology
  • Circulation Research
  • Blood
  • Nature Communications

Best Publications

  • Signaling During Platelet Adhesion and Activation

    Zhenyu Li;M. Keegan Delaney;Kelly A. O'Brien;Xiaoping Du

  • Inside-out integrin signalling

    Mark H. Ginsberg;Xiaoping Du;Edward F. Plow

  • Ligands “activate” integrin αIIbβ3 (platelet GPIIb-IIIa)

    Xiaoping Du;Edward F. Plow;Andrew L. Frelinger;Timothy E. O'Toole

  • Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function.

    Andrew L. Frelinger;Andrew L. Frelinger;Xiaoping Du;Edward F. Plow;Mark H. Ginsberg

  • Lipopolysaccharide Stimulates Platelet Secretion and Potentiates Platelet Aggregation via TLR4/MyD88 and the cGMP-Dependent Protein Kinase Pathway

    Guoying Zhang;Jingyan Han;Emily J. Welch;Richard D. Ye

  • Affinity modulation of the alpha IIb beta 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor.

    Timothy E. O'Toole;Joseph C. Loftus;Xiaoping Du;Alison A. Glass

  • A stimulatory role for cGMP-dependent protein kinase in platelet activation.

    Zhenyu Li;Xiaodong Xi;Minyi Gu;Robert Feil

  • New Concepts and Mechanisms of Platelet Activation Signaling.

    Brian Estevez;Xiaoping Du

  • G protein subunit Gα13 binds to integrin αIIbβ3 and mediates integrin “outside-in” signaling

    Haixia Gong;Bo Shen;Panagiotis Flevaris;Christina Chow

  • Long range propagation of conformational changes in integrin alpha IIb beta 3.

    Xiaoping Du;Minyi Gu;J. W. Weisel;C. Nagaswami

  • Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

    Bo Shen;M Keegan Delaney;Xiaoping Du

  • Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane.

    Xiaoping Du;Lucinda Beutler;Changgeng Ruan;Peter A. Castaldi

  • Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway.

    Panagiotis Flevaris;Zhenyu Li;Guoying Zhang;Yi Zheng

  • Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit

    Xiaoping Du;Takaomi C. Saido;Satoshi Tsubuki;Fred E. Indig

  • A molecular switch that controls cell spreading and retraction.

    Panagiotis Flevaris;Aleksandra Stojanovic;Haixia Gong;Athar Chishti

  • Ristocetin-dependent reconstitution of binding of von Willebrand factor to purified human platelet membrane glycoprotein Ib-IX complex.

    Michael C. Berndt;Xiaoping Du;William J. Booth

  • Identification of a Binding Sequence for the 14-3-3 Protein within the Cytoplasmic Domain of the Adhesion Receptor, Platelet Glycoprotein Ibα (∗)

    Xiaoping Du;Joan E. Fox;Susan Pei

  • Signaling and regulation of the platelet glycoprotein Ib-IX-V complex.

    Xiaoping Du

  • Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin αIIbβ3 Using a Reconstituted Mammalian Cell Expression Model

    Minyi Gu;Xiaodong Xi;Graham D. Englund;Michael C. Berndt

  • A directional switch of integrin signalling and a new anti-thrombotic strategy

    Bo Shen;Xiaojuan Zhao;Kelly A. O’Brien;Aleksandra Stojanovic-Terpo

Frequent Co-Authors

Mark H. Ginsberg
Mark H. Ginsberg University of California, San Diego
Nissim Hay
Nissim Hay University of Illinois at Chicago
Michael C. Berndt
Michael C. Berndt Curtin University
Richard D. Minshall
Richard D. Minshall University of Illinois at Chicago
Richard D. Ye
Richard D. Ye Chinese University of Hong Kong, Shenzhen
Yi Zheng
Yi Zheng Cincinnati Children's Hospital Medical Center
Asrar B. Malik
Asrar B. Malik University of Illinois at Chicago
Randal A. Skidgel
Randal A. Skidgel University of Illinois at Chicago
Edward F. Plow
Edward F. Plow Cleveland Clinic Lerner College of Medicine
Zaverio M. Ruggeri
Zaverio M. Ruggeri Scripps Research Institute

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