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Biology and Biochemistry

D-Index
113
Citations
44284
World Ranking
859
National Ranking
537

Overview

Sanford J. Shattil is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology with a focus on subfields including Hematology, Immunology and Allergy, Cell Biology, Molecular Biology, and Internal Medicine.

The scientist's work covers a range of topics centered on cellular and molecular processes, particularly related to blood and immune system disorders. Main topics of interest include:

  • Cell Adhesion Molecules Research
  • Platelet Disorders and Treatments
  • Cellular Mechanics and Interactions
  • Venous Thromboembolism Diagnosis and Management
  • Case Reports on Hematomas
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Amyloidosis: Diagnosis, Treatment, Outcomes

Sanford J. Shattil has co-authored articles with researchers such as Ana Kasirer-Friede, Gilbert White, Michael B. Streiff, Bjorn Holmstrom, and Dana E. Angelini.

The scientist's recent publications include:

  • Cancer-Associated Venous Thromboembolic Disease, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology, 2021, PubMed
  • Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia, 2020, Nucleic Acid Therapeutics
  • Platelet SHARPIN regulates platelet adhesion and inflammatory responses through associations with αIIbβ3 and LUBAC, 2022, Blood Advances
  • Talin, a Rap1 effector for integrin activation at the plasma membrane, also promotes Rap1 activity by disrupting sequestration of Rap1 by SHANK3, 2025, Journal of Cell Science
  • Primary Megakaryocytes Reveal a Role for Transcription Factor Nf-E2 in Integrin αiibβ3 Signaling, 2020, UNC Libraries

The venues where Sanford J. Shattil has frequently published include UNC Libraries, PubMed, Nucleic Acid Therapeutics, Blood Advances, and Journal of Cell Science.

Best Publications

  • Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

    Seiji Tadokoro;Sanford J. Shattil;Koji Eto;Vera Tai

  • Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.

    S J Shattil;J A Hoxie;M Cunningham;L F Brass

  • The final steps of integrin activation: the end game

    Sanford J. Shattil;Chungho Kim;Mark H. Ginsberg

  • Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry

    Sanford J. Shattil;Michael Cunningham;James A. Hoxie

  • Integrin Signaling: The Platelet Paradigm

    Sanford J. Shattil;Hirokazu Kashiwagi;Nisar Pampori

  • Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

    P J Sims;E M Faioni;T Wiedmer;S J Shattil

  • Integrin cytoplasmic domains mediate inside-out signal transduction

    Timothy E. O'Toole;Yasuhiro Katagiri;Yasuhiro Katagiri;Randall J. Faull;Randall J. Faull;Karlheinz Peter;Karlheinz Peter

  • Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.

    P J Sims;T Wiedmer;C T Esmon;H J Weiss

  • Integrin activation controls metastasis in human breast cancer

    Brunhilde Felding-Habermann;Timothy E. O'Toole;Jeffrey W. Smith;Emilia Fransvea

  • Breaking the Integrin Hinge A DEFINED STRUCTURAL CONSTRAINT REGULATES INTEGRIN SIGNALING

    Paul E. Hughes;Federico Diaz-Gonzalez;Lilley Leong;Chuanyue Wu

  • Integrins: dynamic scaffolds for adhesion and signaling in platelets.

    Sanford J. Shattil;Peter J. Newman

  • Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment.

    Eleni Tzima;Miguel Angel del Pozo;Sanford J. Shattil;Shu Chien

  • Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling.

    David A. Calderwood;Sanford J. Shattil;Mark H. Ginsberg

  • Src kinase activation by direct interaction with the integrin β cytoplasmic domain

    Elena García Arias-Salgado;Sergio Lizano;Sugata Sarkar;Joan S. Brugge

  • Platelet hypersensitivity induced by cholesterol incorporation.

    S J Shattil;R Anaya-Galindo;J Bennett;R W Colman

  • A Mechanism for Modulation of Cellular Responses to VEGF: Activation of the Integrins

    Tatiana V. Byzova;Corey K. Goldman;Nisar Pampori;Kenneth A. Thomas

  • Direct detection of activated platelets and platelet-derived microparticles in humans

    Charles S. Abrams;N. Ellison;A.Z. Budzynski;S.J. Shattil

  • Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

    Min-Mei Huang;Joseph B. Bolen;John W. Barnwell;Sanford J. Shattil

  • Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

    Jaewon Han;Chinten James Lim;Naohide Watanabe;Alessandra Soriani

  • Integrin-based therapeutics: biological basis, clinical use and new drugs

    Klaus Ley;Jesus Rivera-Nieves;William J. Sandborn;Sanford Shattil

Frequent Co-Authors

Mark H. Ginsberg
Mark H. Ginsberg University of California, San Diego
Joan S. Brugge
Joan S. Brugge Harvard University
Joel S. Bennett
Joel S. Bennett University of Pennsylvania
Zaverio M. Ruggeri
Zaverio M. Ruggeri Scripps Research Institute
Lawrence F. Brass
Lawrence F. Brass University of Pennsylvania
Koji Eto
Koji Eto Kyoto University
David A. Cheresh
David A. Cheresh University of California, San Diego
Martin A. Schwartz
Martin A. Schwartz Yale University
Dwayne G. Stupack
Dwayne G. Stupack University of California, San Diego
Peter J. Sims
Peter J. Sims University of Rochester

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