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D-Index
86
Citations
22285
World Ranking
14294
National Ranking
596

Overview

Ladan Fazli is affiliated with the University of British Columbia in Canada, focusing their research primarily on medical and biochemical fields. Their work spans medicine, biochemistry, genetics, and molecular biology, with a notable concentration on prostate cancer treatment and research. Fazli's publications demonstrate an extensive engagement with molecular biology and oncology subfields, exploring complex biological pathways and therapeutic strategies.

Their research topics include:

  • Prostate Cancer Treatment and Research
  • PARP inhibition in cancer therapy
  • Prostate Cancer Diagnosis and Treatment
  • Ubiquitin and proteasome pathways
  • RNA Research and Splicing
  • Cancer, Lipids, and Metabolism
  • Cancer, Hypoxia, and Metabolism

Frequent publication venues for Ladan Fazli include:

  • Cancer Research
  • Oncogene
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research

Their recent papers showcase diverse contributions to cancer research and molecular biology:

  • Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer, 2021, Nature Communications
  • An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer, 2021, Nature Cell Biology
  • LIN28B promotes the development of neuroendocrine prostate cancer, 2020, Journal of Clinical Investigation
  • CRISPR screens reveal genetic determinants of PARP inhibitor sensitivity and resistance in prostate cancer, 2023, Nature Communications
  • A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation, 2021, Nature Cell Biology

Ladan Fazli has collaborated frequently with other researchers, indicating a sustained network of co-authorship in their field. Their frequent co-authors include:

  • Martin Gleave
  • Sonia H.Y. Kung
  • Xuesen Dong
  • Neetu Saxena
  • Yuzhuo Wang

Best Publications

  • Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.

    Meritxell Gironella;Mylène Seux;Min-Jue Xie;Carla Cano

  • The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

    Charles E Massie;Andy Lynch;Antonio Ramos-Montoya;Joan Boren

  • Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.

    Elahe A. Mostaghel;Stephanie T. Page;Daniel W. Lin;Ladan Fazli

  • Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

    Hiroshi Tanaka;Evelyn Kono;Chau P Tran;Hideyo Miyazaki

  • Heat Shock Protein 27 Increases after Androgen Ablation and Plays a Cytoprotective Role in Hormone-Refractory Prostate Cancer

    Palma Rocchi;Alan So;Satoko Kojima;Maxim Signaevsky

  • The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer.

    Jennifer L Bishop;Daksh Thaper;Daksh Thaper;Sepideh Vahid;Sepideh Vahid;Alastair Davies

  • High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

    Dong Lin;Alexander W. Wyatt;Hui Xue;Yuwei Wang

  • Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.

    Qian Wang;Qian Wang;Rae Anne Hardie;Rae Anne Hardie;Andrew J. Hoy;Michelle Van Geldermalsen;Michelle Van Geldermalsen

  • Regulation of tumor angiogenesis by integrin-linked kinase (ILK)

    Clara Tan;Severine Cruet-Hennequart;Armelle Troussard;Ladan Fazli

  • A Phase I Pharmacokinetic and Pharmacodynamic Study of OGX-011, a 2′-Methoxyethyl Antisense Oligonucleotide to Clusterin, in Patients With Localized Prostate Cancer

    Kim N. Chi;Elizabeth Eisenhauer;Ladan Fazli;Edward C. Jones

  • Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity.

    Amina Zoubeidi;Anousheh Zardan;Eliana Beraldi;Ladan Fazli

  • Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers

    Ashish B Rajput;Melinda A Miller;Alessandro De Luca;Niki Boyd

  • Insulin receptor expression by human prostate cancers

    Michael E. Cox;Martin E. Gleave;Mahvash Zakikhani;Robert H. Bell

  • The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

    Shusuke Akamatsu;Alexander W. Wyatt;Dong Lin;Summer Lysakowski

  • Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

    Ali Salanti;Thomas M Clausen;Mette Ø Agerbæk;Nader Al Nakouzi;Nader Al Nakouzi

  • The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells.

    Yingqiu Xie;Kexin Xu;Douglas E. Linn;Xi Yang

  • Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer.

    Masaki Shiota;Jennifer L. Bishop;Ka Mun Nip;Anousheh Zardan

  • Increased Insulin-Like Growth Factor I Receptor Expression and Signaling Are Components of Androgen-Independent Progression in a Lineage-Derived Prostate Cancer Progression Model

    Sandra L. Krueckl;Robert A. Sikes;N. Magnus Edlund;Robert H. Bell

  • Increased Hsp27 after androgen ablation facilitates androgen-independent progression in prostate cancer via signal transducers and activators of transcription 3-mediated suppression of apoptosis.

    Palma Rocchi;Eliana Beraldi;Susan Ettinger;Ladan Fazli

  • Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer

    Liesel M FitzGerald;Ilir Agalliu;Ilir Agalliu;Karynn Johnson;Melinda A Miller

Frequent Co-Authors

Martin E. Gleave
Martin E. Gleave University of British Columbia
Amina Zoubeidi
Amina Zoubeidi University of British Columbia
Yuzhuo Wang
Yuzhuo Wang University of British Columbia
Colleen C. Nelson
Colleen C. Nelson Queensland University of Technology
Colin Collins
Colin Collins University of British Columbia
Alexander W. Wyatt
Alexander W. Wyatt University of British Columbia
Kim N. Chi
Kim N. Chi BC Cancer Agency
Peter S. Nelson
Peter S. Nelson Fred Hutchinson Cancer Research Center
Himisha Beltran
Himisha Beltran Harvard University
Peter McL. Black
Peter McL. Black University of British Columbia

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