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Molecular Biology

D-Index
58
Citations
11372
World Ranking
2095
National Ranking
66

Overview

Alexander W. Wyatt is a researcher affiliated with the University of British Columbia in Canada. Their work spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on specialized subfields such as Pulmonary and Respiratory Medicine, Cancer Research, Molecular Biology, Oncology, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics are concentrated on areas related to cancer diagnosis and treatment, notably:

  • Prostate Cancer Treatment and Research
  • Cancer Genomics and Diagnostics
  • Prostate Cancer Diagnosis and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Bladder and Urothelial Cancer Treatments
  • PARP inhibition in cancer therapy
  • Epigenetics and DNA Methylation

Alexander W. Wyatt has contributed to several recent papers including:

  • "The DNA methylation landscape of advanced prostate cancer," 2020, published in Nature Genetics
  • "Long-Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy Versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials," 2022, published in Journal of Clinical Oncology
  • "Deep whole-genome ctDNA chronology of treatment-resistant prostate cancer," 2022, published in Nature
  • "Plasma ctDNA is a tumor tissue surrogate and enables clinical-genomic stratification of metastatic bladder cancer," 2021, published in Nature Communications
  • "Evaluating the quantity, quality and size distribution of cell-free DNA by multiplex droplet digital PCR," 2020, published in Scientific Reports

Their frequent co-authors are:

  • Kim N.
  • Matti Annala
  • Gillian Vandekerkhove
  • Cameron Herberts
  • Edmond M. Kwan

Alexander W. Wyatt has published regularly in leading scientific venues including:

  • Journal of Clinical Oncology (31 publications)
  • Clinical Cancer Research (14 publications)
  • Cancer Research (11 publications)
  • Annals of Oncology (6 publications)
  • Nature Communications (4 publications)

Best Publications

  • Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.

    David A. Quigley;Ha X. Dang;Shuang G. Zhao;Paul Lloyd

  • Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer

    Arun A Azad;Stanislav V Volik;Alexander W Wyatt;Anne Haegert

  • Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer

    Matti Annala;Matti Annala;Gillian Vandekerkhove;Daniel Khalaf;Sinja Taavitsainen

  • Concordance of Circulating Tumor DNA and Matched Metastatic Tissue Biopsy in Prostate Cancer

    Alexander W Wyatt;Matti Annala;Rahul Aggarwal;Kevin Beja

  • The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer.

    Jennifer L Bishop;Daksh Thaper;Daksh Thaper;Sepideh Vahid;Sepideh Vahid;Alastair Davies

  • High Fidelity Patient-Derived Xenografts for Accelerating Prostate Cancer Discovery and Drug Development

    Dong Lin;Alexander W. Wyatt;Hui Xue;Yuwei Wang

  • Genomic Alterations in Cell-Free DNA and Enzalutamide Resistance in Castration-Resistant Prostate Cancer.

    Alexander W. Wyatt;Arun A. Azad;Stanislav V. Volik;Matti Annala

  • Optimal sequencing of enzalutamide and abiraterone acetate plus prednisone in metastatic castration-resistant prostate cancer: a multicentre, randomised, open-label, phase 2, crossover trial.

    Daniel J Khalaf;Matti Annala;Sinja Taavitsainen;Sinja Taavitsainen;Daygen L Finch

  • Mutations in BMP4 Cause Eye, Brain, and Digit Developmental Anomalies: Overlap between the BMP4 and Hedgehog Signaling Pathways

    Preeti Bakrania;Maria Efthymiou;Johannes C. Klein;Alison Salt;Alison Salt

  • The DNA methylation landscape of advanced prostate cancer

    Shuang G. Zhao;Shuang G. Zhao;William S. Chen;William S. Chen;Haolong Li;Adam Foye

  • The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

    Shusuke Akamatsu;Alexander W. Wyatt;Dong Lin;Summer Lysakowski

  • Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors.

    David Quigley;Joshi J Alumkal;Alexander W. Wyatt;Vishal Kothari

  • Treatment Outcomes and Tumor Loss of Heterozygosity in Germline DNA Repair–deficient Prostate Cancer

    Matti Annala;Werner J. Struss;Evan W. Warner;Kevin Beja

  • From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer

    Anna V Lapuk;Chunxiao Wu;Alexander W Wyatt;Andrew McPherson;Andrew McPherson

  • Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients

    Nada Lallous;Stanislav V. Volik;Shannon Awrey;Eric Leblanc

  • Circulating Tumor DNA Abundance and Potential Utility in De Novo Metastatic Prostate Cancer

    Gillian Vandekerkhove;Werner J. Struss;Matti Annala;Heini M.L. Kallio

  • Erratum: Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer (Cell (2018) 174(3) (758–769.e9), (S0092867418308420) (10.1016/j.cell.2018.06.039))

    David A. Quigley;Ha X. Dang;Shuang G. Zhao;Paul Lloyd

  • Circulating Tumor DNA Reveals Clinically Actionable Somatic Genome of Metastatic Bladder Cancer.

    Gillian Vandekerkhove;Tilman Todenhöfer;Tilman Todenhöfer;Matti Annala;Matti Annala;Werner J. Struss

  • Targeting the adaptive molecular landscape of castration-resistant prostate cancer

    Alexander W Wyatt;Martin E Gleave

  • Generation 2.5 Antisense Oligonucleotides Targeting the Androgen Receptor and Its Splice Variants Suppress Enzalutamide-Resistant Prostate Cancer Cell Growth

    Yoshiaki Yamamoto;Yohann Loriot;Eliana Beraldi;Fan Zhang

Frequent Co-Authors

Kim N. Chi
Kim N. Chi BC Cancer Agency
Martin E. Gleave
Martin E. Gleave University of British Columbia
Colin Collins
Colin Collins University of British Columbia
Ladan Fazli
Ladan Fazli University of British Columbia
Yuzhuo Wang
Yuzhuo Wang University of British Columbia
Amina Zoubeidi
Amina Zoubeidi University of British Columbia
Himisha Beltran
Himisha Beltran Harvard University
Eric J. Small
Eric J. Small University of California, San Francisco
Mark A. Rubin
Mark A. Rubin University of Bern
Paul C. Boutros
Paul C. Boutros University of California, Los Angeles

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