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Jan Krzysztof Blusztajn

Jan Krzysztof Blusztajn

D-Index & Metrics

Neuroscience

D-Index
63
Citations
14375
World Ranking
3394
National Ranking
1574

Overview

Jan Krzysztof Blusztajn is affiliated with Boston University in the United States. Their research spans several fields within biochemistry, genetics, molecular biology, and medicine, concentrating on areas such as molecular biology, physiology, neurology, cancer research, and clinical biochemistry.

The scientist's work extensively covers topics related to Alzheimer's disease research and treatments, microRNA in disease regulation, metabolism and genetic disorders, tryptophan and brain disorders, neurological disorders and treatments, neurological disease mechanisms and treatments, and extracellular vesicles in disease.

Selected recent publications illustrate the scope and focus of their research. These include:

  • Accelerated Breakdown of Phosphatidylcholine and Phosphatidylethanolamine Is a Predominant Brain Metabolic Defect in Alzheimer's Disease, 2023, Journal of Alzheimer's Disease
  • Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study, 2022, American Journal of Clinical Nutrition
  • MicroRNAs as Candidate Biomarkers for Alzheimer's Disease, 2021, Non-Coding RNA
  • The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals, 2024, Alzheimer's & Dementia
  • Plasma miRNAs across the Alzheimer's disease continuum: Relationship to central biomarkers, 2024, Alzheimer's & Dementia

Jan Krzysztof Blusztajn frequently collaborates with several coauthors, including Tiffany J. Mellott, Ivana Delalle, Honghuang Lin, André Fischer, and Andre Krunic. This network demonstrates a collaborative approach in studying complex biological and neurological issues.

Their research is published in a range of venues, with multiple contributions to journals such as Alzheimer's & Dementia, Journal of Alzheimer's Disease, Aging Cell, UNC Libraries, and American Journal of Clinical Nutrition.

Best Publications

  • Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

    Lee E. Goldstein;Andrew M. Fisher;Chad A. Tagge;Xiao-Lei Zhang

  • Choline and Human Nutrition

    Steven H. Zeisel;Jan K. Blusztajn

  • Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons.

    Neil R. Cashman;Heather D. Durham;Jan Krzysztof Blusztajn;Kenichiro Oda

  • Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation

    C.A. Lemere;J.K. Blusztajn;H. Yamaguchi;T. Wisniewski

  • Evidence for a membrane defect in Alzheimer disease brain.

    Roger M. Nitsch;Jan K. Blusztajn;Anastassios G. Pittas;Barbara E. Slack

  • Choline and cholinergic neurons.

    Jan K. Blusztajn;Richard J. Wurtman

  • Choline, a Vital Amine

    Jan Krzysztof Blusztajn

  • Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.

    Pingfang Song;Harmanjatinder S. Sekhon;Yibing Jia;Jennifer A. Keller

  • Formation of methylamines from ingested choline and lecithin.

    S H Zeisel;J S Wishnok;J K Blusztajn

  • Neuroprotective Actions of Dietary Choline

    Jan Krzysztof Blusztajn;Barbara E. Slack;Tiffany J. Mellott

  • Choline increases acetylcholine release and protects against the stimulation-induced decrease in phosphatide levels within membranes of rat corpus striatum

    Ismail H. Ulus;Richard J. Wurtman;Charlotte Mauron;Jan Krzysztof Blusztajn

  • Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line.

    Brygida Berse;Jan Krzysztof Blusztajn

  • Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell line.

    Jan Krzysztof Blusztajn;M. Liscovitch;U. I. Richardson

  • Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

    Ward A. Pedersen;Marek A. Kloczewiak;Jan Krzysztof Blusztajn

  • Developmental Periods of Choline Sensitivity Provide an Ontogenetic Mechanism for Regulating Memory Capacity and Age-Related Dementia

    Warren H. Meck;Christina L. Williams;Jennifer Marie Cermak;Jan Krzysztof Blusztajn

  • Prenatal availability of choline modifies development of the hippocampal cholinergic system

    Jennifer Marie Cermak;Thomas Holler;Darrell A. Jackson;Jan Krzysztof Blusztajn

  • Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain

    Jan K. Blusztajn;Steven H. Zeisel;Richard J. Wurtman

  • Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.

    Tiffany J. Mellott;Christina L. Williams;Warren H. Meck;Jan Krzysztof Blusztajn

  • "Autocannibalism" of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease-A hypothesis.

    Richard J. Wurtman;Jan K. Blusztajn;Jean-Claude Maire

  • A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization

    Hanzhong Li;Susan E. Leeman;Barbara E. Slack;George Hauser

  • Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus.

    Gregory L Holmes;Yili Yang;Zhao Liu;Jennifer M Cermak

  • Levels of phospholipid catabolic intermediates, glycerophosphocholine and glycerophosphoethanolamine, are elevated in brains of Alzheimer's disease but not of Down's syndrome patients.

    Jan Krzysztof Blusztajn;Ignacio Lopez Gonzalez-Coviella;Mary Logue;John H. Growdon

  • Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency.

    Eugene P Brandon;Tiffany Mellott;Donald P Pizzo;Nicole Coufal

  • IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.

    Tiffany J. Mellott;Sarah M. Pender;Rebecca M. Burke;Erika A. Langley

  • Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats

    Melissa J. Glenn;Elizabeth D. Kirby;Erin M. Gibson;Sarah J. Wong-Goodrich

Frequent Co-Authors

Christina L. Williams
Christina L. Williams Duke University
Warren H. Meck
Warren H. Meck Duke University
Ann C. McKee
Ann C. McKee Boston University
Andrew E. Budson
Andrew E. Budson Boston University
Rudolph E. Tanzi
Rudolph E. Tanzi Harvard University
Patric K. Stanton
Patric K. Stanton New York Medical College
Bruce G. Jenkins
Bruce G. Jenkins Harvard University
Sudha Seshadri
Sudha Seshadri The University of Texas Health Science Center at San Antonio
Bruce H. Wainer
Bruce H. Wainer Emory University
Alexa Beiser
Alexa Beiser Boston University

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