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Medicine

D-Index
84
Citations
23856
World Ranking
15194
National Ranking
7668

Overview

Alfredo A. Sadun is affiliated with the University of California, Los Angeles in the United States. Their research spans multiple domains within the life sciences, with a particular focus on the fields of biochemistry, genetics, and molecular biology, alongside medicine.

The primary areas of study in their work include molecular biology and ophthalmology, supplemented by contributions to radiology, nuclear medicine, imaging, neurology, and clinical biochemistry. This multidisciplinary approach supports investigations into complex biological and clinical questions, especially those related to vision and neurological conditions.

The central themes of Sadun's research cover retinal development and disorders, mitochondrial function and pathology, retinal diseases and treatments, glaucoma and retinal disorders, ATP synthase and ATPases research, photosynthetic processes and mechanisms, as well as retinal imaging and analysis.

Frequent co-authors collaborating with Sadun include Valério Carelli, Patrick Yu-Wai-Man, Valérie Biousse, Mark L. Moster, and Chiara La Morgia. Their published work appears consistently in several peer-reviewed journals. Notable venues featuring their research comprise the Journal of Neuro-Ophthalmology, Acta Ophthalmologica, Neurology, Ophthalmology, and Brain.

Some recent publications authored or co-authored by Sadun highlight advances in gene therapy and eye disease mechanisms:

  • Bilateral visual improvement with unilateral gene therapy injection for Leber hereditary optic neuropathy, 2020, Science Translational Medicine
  • Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset, 2021, Ophthalmology
  • Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy, 2020, Nature Communications
  • Glaucoma as Neurodegeneration in the Brain, 2021, Eye and Brain
  • Long-Term Follow-Up After Unilateral Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy: The RESTORE Study, 2020, Journal of Neuro-Ophthalmology

Best Publications

  • Mitochondrial dysfunction as a cause of optic neuropathies

    Valerio Carelli;Fred N. Ross-Cisneros;Alfredo A. Sadun

  • Optic-Nerve Degeneration in Alzheimer's Disease

    David R. Hinton;Alfredo A. Sadun;Janet C. Blanks;Carol A. Miller

  • Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone.

    Steven M. Grunberg;Martin H. Weiss;Irving M. Spitz;Jamshid Ahmadi

  • Optic Nerve Damage in Alzheimer's Disease

    Alfredo A. Sadun;Carl J. Bassi

  • Melanopsin retinal ganglion cell loss in Alzheimer disease

    Chiara La Morgia;Fred N. Ross‐Cisneros;Yosef Koronyo;Jens Hannibal

  • Clinical Expression of Leber Hereditary Optic Neuropathy Is Affected by the Mitochondrial DNA–Haplogroup Background

    Gavin Hudson;Valerio Carelli;Valerio Carelli;Liesbeth Spruijt;Mike Gerards

  • Optic Nerve Decompression Surgery for Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Is Not Effective and May Be Harmful

    Frank Ischemic;Frank Hooper;David Kaufman;Nancy J. Newman

  • Retinal ganglion cell degeneration in Alzheimer's disease.

    Janet C. Blanks;David R. Hinton;David R. Hinton;Alfredo A. Sadun;Carol A. Miller;Carol A. Miller

  • Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.

    Carla Giordano;Luisa Iommarini;Luca Giordano;Alessandra Maresca

  • Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies.

    Valerio Carelli;Fred N. Ross-Cisneros;Alfredo A. Sadun

  • Assessment of visual impairment in patients with Alzheimer's disease.

    Alfredo A. Sadun;Mark Borchert;Edward DeVita;David R. Hinton

  • Correlation between retinal nerve fibre layer thickness and optic nerve head size: an optical coherence tomography study

    Giacomo Savini;M. Zanini;V. Carelli;A. A. Sadun

  • Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders

    Valerio Carelli;Chiara La Morgia;Maria Lucia Valentino;Piero Barboni

  • Oestrogens ameliorate mitochondrial dysfunction in Leber’s hereditary optic neuropathy

    Carla Giordano;Monica Montopoli;Elena Perli;Maurizia Orlandi

  • Idebenone treatment in Leber's hereditary optic neuropathy.

    Valerio Carelli;Chiara La Morgia;Maria Lucia Valentino;Giovanni Rizzo

  • Leber's hereditary optic neuropathy differentially affects smaller axons in the optic nerve.

    A A Sadun;P H Win;F N Ross-Cisneros;S O Walker

  • Haplogroup effects and recombination of mitochondrial DNA: novel clues from the analysis of Leber hereditary optic neuropathy pedigrees.

    Valerio Carelli;Valerio Carelli;Alessandro Achilli;Maria Lucia Valentino;Chiara Rengo

  • Mouse mtDNA mutant model of Leber hereditary optic neuropathy

    Chun Shi Lin;Mark S. Sharpley;Mark S. Sharpley;Weiwei Fan;Katrina G. Waymire

  • Natural History of Leber's Hereditary Optic Neuropathy: Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography

    Piero Barboni;Michele Carbonelli;Giacomo Savini;Carolina do V.F. Ramos

  • Age-related decline of human optic nerve axon populations

    Betty M. Johnson;Michael Miao;Alfredo A. Sadun

Frequent Co-Authors

Valerio Carelli
Valerio Carelli University of Bologna
Rubens Belfort
Rubens Belfort Federal University of Sao Paulo
Maria Lucia Valentino
Maria Lucia Valentino University of Bologna
Patrick Yu-Wai-Man
Patrick Yu-Wai-Man University of Cambridge
William R. Freeman
William R. Freeman University of California, San Diego
Jens Hannibal
Jens Hannibal University of Copenhagen
Vincenzo Parisi
Vincenzo Parisi University of Rome Tor Vergata
Carla Giordano
Carla Giordano Sapienza University of Rome
Nancy J. Newman
Nancy J. Newman Emory University
Thomas Klopstock
Thomas Klopstock Ludwig-Maximilians-Universität München

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