World's Best Scientists 2026 revealed!

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Microbiology

D-Index
52
Citations
13158
World Ranking
4166
National Ranking
242

Molecular Biology

D-Index
58
Citations
15143
World Ranking
2067
National Ranking
72

Overview

Guy Lenaers is affiliated with the University of Angers in France and has contributed extensively to research in the fields of biochemistry, genetics, and molecular biology, with a notable emphasis on medicine. Their research portfolio includes significant work in molecular biology, genetics, physiology, clinical biochemistry, and neurology.

The main topics of their work cover a variety of areas related to mitochondrial function and pathology, ATP synthase and ATPases research, metabolism and genetic disorders, retinal development and disorders, genomics and rare diseases, metabolomics and mass spectrometry studies, as well as adipose tissue and metabolism.

Recent papers authored or co-authored by Guy Lenaers include:

  • OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases, 2023, Communications Biology
  • Dominant optic atrophy: Culprit mitochondria in the optic nerve, 2020, Progress in Retinal and Eye Research
  • Lactic Acidosis Together with GM-CSF and M-CSF Induces Human Macrophages toward an Inflammatory Protumor Phenotype, 2020, Cancer Immunology Research
  • Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging, 2023, Psychoneuroendocrinology
  • Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology, 2020, Nature Communications

Frequent collaborators in their research include Majida Charif, Vincent Procaccio, Pascal Reynier, Dominique Bonneau, and Naïg Guéguen.

Their work has appeared in a variety of publication venues with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Brain Communications, Mitochondrion, Revue Neurologique, and Brain. These venues reflect the interdisciplinary nature of their research, intersecting molecular biology, neurological studies, and mitochondrial science.

Best Publications

  • Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

    C Delettre;G Lenaers;J-M Griffoin;N Gigarel

  • Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

    Aurélien Olichon;Laurent Baricault;Nicole Gas;Emmanuelle Guillou

  • OPA1 mutations induce mitochondrial DNA instability and optic atrophy plus phenotypes

    Patrizia Amati-Bonneau;Maria Lucia Valentino;Pascal Reynier;Maria Esther Gallardo

  • The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.

    Aurélien Olichon;Laurent J Emorine;Eric Descoins;Laetitia Pelloquin

  • Multi-system neurological disease is common in patients with OPA1 mutations

    Patrick Yu-Wai-Man;Philip G. Griffiths;Philip G. Griffiths;G. Gorman;C.-M. Lourenco

  • Mutation spectrum and splicing variants in the OPA1 gene.

    Cécile Delettre;Jean-Michel Griffoin;Josseline Kaplan;Hélène Dollfus

  • p80cdc25 mitotic inducer is the tyrosine phosphatase that activates p34cdc2 kinase in fission yeast.

    J. B. Millar;C. H. McGowan;G. Lenaers;Robert Jones

  • Dinoflagellates in evolution. A molecular phylogenetic analysis of large subunit ribosomal RNA.

    G. Lenaers;L. Maroteaux;B. Michot;M. Herzog

  • Dominant optic atrophy

    Guy Lenaers;Christian P Hamel;Cecile Delettre;Patrizia Amati-Bonneau;Patrizia Amati-Bonneau

  • Mitochondrial dynamics and disease, OPA1.

    Aurélien Olichon;Emmanuelle Guillou;Cécile Delettre;Thomas Landes

  • TRPV4 channels mediate the infrared laser-evoked response in sensory neurons.

    Emmanuelle Sandrine Albert;Jean-Michel Bec;Gilles Desmadryl;Karim Chekroud

  • OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution.

    Ghizlane Elachouri;Sara Vidoni;Claudia Zanna;Alexandre Pattyn

  • OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis

    Aurélien Olichon;Aurélien Olichon;Ghizlane Elachouri;Laurent Baricault;Cécile Delettre

  • OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions

    Valentina Del Dotto;Valentina Del Dotto;Prashant Mishra;Sara Vidoni;Mario Fogazza

  • OPA1 (Kjer Type) Dominant Optic Atrophy: A Novel Mitochondrial Disease

    Cécile Delettre;Guy Lenaers;Laeticia Pelloquin;Pascale Belenguer

  • The role of glia, mitochondria, and the immune system in glaucoma.

    Gülgün Tezel;Tamir Ben-Hur;Gary E. Gibson;Beth Stevens

  • OPA1 R445H mutation in optic atrophy associated with sensorineural deafness

    Patrizia Amati-Bonneau;Agnès Guichet;Aurélien Olichon;Arnaud Chevrollier

  • Effects of OPA1 mutations on mitochondrial morphology and apoptosis: relevance to ADOA pathogenesis.

    Aurélien Olichon;Thomas Landes;Laetitia Arnauné-Pelloquin;Laurent J. Emorine

  • Mitochondrial fusion is frequent in skeletal muscle and supports excitation–contraction coupling

    Verónica Eisner;Guy Lenaers;György Hajnóczky

  • OPA3 gene mutations responsible for autosomal dominant optic atrophy and cataract

    P Reynier;P Amati-Bonneau;C Verny;A Olichon

Frequent Co-Authors

Pascal Reynier
Pascal Reynier University of Angers
Dominique Bonneau
Dominique Bonneau University of Angers
Vincent Procaccio
Vincent Procaccio University of Angers
Valerio Carelli
Valerio Carelli University of Bologna
Daniel Henrion
Daniel Henrion University of Angers
Josseline Kaplan
Josseline Kaplan Université Paris Cité
Patrick Yu-Wai-Man
Patrick Yu-Wai-Man University of Cambridge
Bernd Wissinger
Bernd Wissinger University of Tübingen
Patrick F. Chinnery
Patrick F. Chinnery University of Cambridge

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