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Christian P. Hamel

Christian P. Hamel

D-Index & Metrics

Genetics

D-Index
65
Citations
17907
World Ranking
2684
National Ranking
125

Overview

Christian P. Hamel was affiliated with Inserm in France throughout their career. Their research expertise spanned several domains within the life sciences, notably in biochemistry, genetics, and molecular biology as well as medicine.

Hamel's work focused on multiple main topics, including retinal development and disorders, CRISPR and genetic engineering, RNA regulation and disease, photochromic and fluorescence chemistry, photoreceptor and optogenetics research, retinal and optic conditions, and retinal imaging and analysis.

The scientist's research output included publications in prominent venues such as The CRISPR Journal and PNAS Nexus. Some of the recent papers authored or co-authored by Hamel include:

  • CRISPR-AsCas12a Efficiently Corrects a GPR143 Intronic Mutation in Induced Pluripotent Stem Cells from an Ocular Albinism Patient, 2022, The CRISPR Journal
  • Productive infection of the retinal pigment epithelium by SARS-CoV-2: Initial effects and consideration of long-term consequences, 2024, PNAS Nexus

Their research frequently intersected with several scientific subfields, particularly molecular biology, ophthalmology, materials chemistry, cellular and molecular neuroscience, and radiology, nuclear medicine, and imaging.

Hamel collaborated regularly with other researchers, among them Zhour Jazouli, Vasiliki Kalatzis, Edouard Baulier, Alejandro Garcia Diaz, and Barbara Corneo. These collaborations contributed to advancing investigations primarily related to retinal biology and genetic engineering.

Throughout their scientific contributions, Hamel concentrated on elucidating mechanisms underlying retinal diseases and genetic modifications using advanced molecular and cellular techniques. Their interdisciplinary approach bridged genetic engineering methods such as CRISPR with clinical and imaging studies relevant to ophthalmology and neuroscience.

While no book publications or awards were recorded, Hamel's body of work included multiple papers across several fields and specialized topics, highlighting a sustained engagement with both basic and applied life sciences research.

Best Publications

  • Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

    C Delettre;G Lenaers;J-M Griffoin;N Gigarel

  • Retinitis pigmentosa

    Christian Hamel

  • Mutations in RPE65 cause Leber's congenital amaurosis

    Marlhens F;Bareil C;Griffoin Jm;Zrenner E

  • Cone rod dystrophies

    Christian P Hamel

  • The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space.

    Aurélien Olichon;Laurent J Emorine;Eric Descoins;Laetitia Pelloquin

  • Leber congenital amaurosis: comprehensive survey of the genetic heterogeneity, refinement of the clinical definition, and genotype-phenotype correlations as a strategy for molecular diagnosis.

    Sylvain Hanein;Isabelle Perrault;Sylvie Gerber;Gaëlle Tanguy

  • Mutation spectrum and splicing variants in the OPA1 gene.

    Cécile Delettre;Jean-Michel Griffoin;Josseline Kaplan;Hélène Dollfus

  • Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin

    Dominique Weil;Aziz El-Amraoui;Saber Masmoudi;Mirna Mustapha

  • BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus.

    Corinne Stoetzel;Virginie Laurier;Erica E. Davis;Jean Muller

  • Dominant optic atrophy

    Guy Lenaers;Christian P Hamel;Cecile Delettre;Patrizia Amati-Bonneau;Patrizia Amati-Bonneau

  • Identification of a Novel BBS Gene (BBS12) Highlights the Major Role of a Vertebrate-Specific Branch of Chaperonin-Related Proteins in Bardet-Biedl Syndrome

    Corinne Stoetzel;Jean Muller;Virginie Laurier;Erica E. Davis

  • Mitochondrial dynamics and disease, OPA1.

    Aurélien Olichon;Emmanuelle Guillou;Cécile Delettre;Thomas Landes

  • TRPM1 Is Mutated in Patients with Autosomal-Recessive Complete Congenital Stationary Night Blindness

    Isabelle Audo;Susanne Kohl;Bart P. Leroy;Francis L. Munier

  • TRPV4 channels mediate the infrared laser-evoked response in sensory neurons.

    Emmanuelle Sandrine Albert;Jean-Michel Bec;Gilles Desmadryl;Karim Chekroud

  • OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution.

    Ghizlane Elachouri;Sara Vidoni;Claudia Zanna;Alexandre Pattyn

  • Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis.

    Isabelle Perrault;Sylvain Hanein;Sylvie Gerber;Fabienne Barbet

  • Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium

    G Le Meur;K Stieger;A J Smith;M Weber

  • OPA1 (Kjer Type) Dominant Optic Atrophy: A Novel Mitochondrial Disease

    Cécile Delettre;Guy Lenaers;Laeticia Pelloquin;Pascale Belenguer

  • OPA1 R445H mutation in optic atrophy associated with sensorineural deafness

    Patrizia Amati-Bonneau;Agnès Guichet;Aurélien Olichon;Arnaud Chevrollier

  • Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65 ☆

    Birgit Lorenz;Bettina Wabbels;Erika Wegscheider;Christian P Hamel

Frequent Co-Authors

Guy Lenaers
Guy Lenaers University of Angers
Dominique Bonneau
Dominique Bonneau University of Angers
Pascal Reynier
Pascal Reynier University of Angers
Josseline Kaplan
Josseline Kaplan Université Paris Cité
Hélène Dollfus
Hélène Dollfus University of Strasbourg
Susanne Kohl
Susanne Kohl University of Tübingen
Bernd Wissinger
Bernd Wissinger University of Tübingen
Jean-Michel Rozet
Jean-Michel Rozet Université Paris Cité
José-Alain Sahel
José-Alain Sahel University of Pittsburgh

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