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D-Index & Metrics

Biology and Biochemistry

D-Index
137
Citations
64803
World Ranking
329
National Ranking
221

Research.com Recognitions

  • 2019 - Member of the National Academy of Medicine (NAM)
  • 2012 - Prize of the Foundation for Polish Science - Nagroda Fundacji na rzecz Nauki Polskiej for characterizing crystal structures of native and activated G protein-coupled receptor, rhodopsin, involved in eyesight

Overview

Krzysztof Palczewski is affiliated with the University of California, Irvine in the United States. Their research spans multiple fields including biochemistry, genetics, molecular biology, and medicine. The work focuses extensively on molecular biology, cellular and molecular neuroscience, ophthalmology, materials chemistry, and genetics.

The central topics covered in their research include retinal development and disorders, photoreceptor and optogenetics research, retinal diseases and treatments, receptor mechanisms and signaling, CRISPR and genetic engineering, retinoids in leukemia and cellular processes, and virus-based gene therapy research.

Notable recent publications by Palczewski and collaborators include:

  • "Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins," 2022, published in Cell
  • "Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo," 2024, published in Nature Biotechnology
  • "Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing," 2020, published in Nature Biomedical Engineering
  • "In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration," 2022, published in Nature Communications
  • "Shedding new light on the generation of the visual chromophore," 2020, published in Proceedings of the National Academy of Sciences

Frequent co-authors working with Palczewski include:

  • Philip D. Kiser
  • Elliot H. Choi
  • Henri Leinonen
  • Zhiqian Dong
  • Samuel W. Du

Palczewski's publications appear most often in these venues:

  • Proceedings of the National Academy of Sciences
  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Biomedical Engineering
  • Nature Communications

Recognition of Palczewski's contributions includes membership in the National Academy of Medicine awarded in 2019. They also received the Prize of the Foundation for Polish Science in 2012 for characterizing crystal structures of native and activated G protein-coupled receptor rhodopsin, which is involved in eyesight.

Best Publications

  • Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

    Krzysztof Palczewski;T. Kumasaka;T. Hori;C. A. Behnke

  • G protein-coupled receptor rhodopsin.

    Krzysztof Palczewski

  • Atomic-force microscopy: Rhodopsin dimers in native disc membranes

    Dimitrios Fotiadis;Yan Liang;Slawomir Filipek;David A. Saperstein

  • Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs).

    David C. Teller;Tetsuji Okada;Craig A. Behnke;Krzysztof Palczewski

  • Organization of the G Protein-coupled Receptors Rhodopsin and Opsin in Native Membranes

    Yan Liang;Dimitrios Fotiadis;Sławomir Filipek;David A. Saperstein

  • Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

    Gregory M. Acland;Gustavo D. Aguirre;Jean Bennett;Tomas S. Aleman

  • Crystal structure of a photoactivated deprotonated intermediate of rhodopsin.

    David Salom;David T. Lodowski;Ronald E. Stenkamp;Isolde Le Trong

  • Activation of rhodopsin: new insights from structural and biochemical studies

    Tetsuji Okada;Oliver P. Ernst;Krzysztof Palczewski;Klaus Peter Hofmann

  • Phagocytosis of retinal rod and cone photoreceptors.

    Brian M. Kevany;Krzysztof Palczewski

  • Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin.

    Tara Mirzadegan;Gil Benkö;Sławomir Filipek;Krzysztof Palczewski

  • Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents.

    Gabriel H. Travis;Marcin Golczak;Alexander R. Moise;Krzysztof Palczewski

  • Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina.

    Joshua K. McBee;Krzysztof Palczewski;Wolfgang Baehr;David R. Pepperberg

  • Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein

    Krzysztof Palczewski;Iswari Subbaraya;Wojciech A. Gorczyca;Bharati S. Helekar

  • Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

    Olaf Fritze;Sławomir Filipek;Vladimir Kuksa;Krzysztof Palczewski

  • Lecithin-retinol Acyltransferase Is Essential for Accumulation of All-trans-Retinyl Esters in the Eye and in the Liver

    Matthew L. Batten;Yoshikazu Imanishi;Tadao Maeda;Daniel C. Tu

  • Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina.

    Yunpeng Du;Alexander Veenstra;Krzysztof Palczewski;Timothy S. Kern;Timothy S. Kern

  • Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina

    Arthur Polans;Wolfgang Baehr;Wolfgang Baehr;Wolfgang Baehr;Krzysztof Palczewski

  • Chemistry and Biology of Vision

    Krzysztof Palczewski

  • Mechanism of Rhodopsin Kinase Activation

    Krzysztof Palczewski;Janina Buczylko;Michael W. Kaplan;Arthur S. Polans

  • Crystal structure of rhodopsin: a G-protein-coupled receptor.

    R. E. Stenkamp;D. C. Teller;K. Palczewski

Frequent Co-Authors

Marcin Golczak
Marcin Golczak Case Western Reserve University
Akiko Maeda
Akiko Maeda Case Western Reserve University
Tadao Maeda
Tadao Maeda Case Western Reserve University
Wolfgang Baehr
Wolfgang Baehr University of Utah
Slawomir Filipek
Slawomir Filipek University of Warsaw
Andreas Engel
Andreas Engel University of Basel
Timothy S. Kern
Timothy S. Kern University of California, Irvine
Johannes von Lintig
Johannes von Lintig Case Western Reserve University
Ronald E. Stenkamp
Ronald E. Stenkamp University of Washington
Paul A. Hargrave
Paul A. Hargrave University of Florida

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