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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
35641
World Ranking
1021
National Ranking
12

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award

Overview

Manfred Wuhrer is affiliated with Leiden University Medical Center in the Netherlands and has a significant body of work spanning multiple domains in biomedical research. Their research contributions are predominantly situated within Medicine and Biochemistry, Genetics, and Molecular Biology, with a strong focus on subfields such as Molecular Biology, Immunology, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics reflect a concentrated expertise in Glycosylation and Glycoproteins Research, with extensive engagement in Monoclonal and Polyclonal Antibodies Research. Additional topics of study include Galectins and Cancer Biology, T-cell and B-cell Immunology, Protein purification and stability, Complement system in diseases, and Carbohydrate Chemistry and Synthesis.

Recent notable publications by Manfred Wuhrer include:

  • "Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity" (2020, Science)
  • "MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation" (2020, Frontiers in Immunology)
  • "IgA subclasses have different effector functions associated with distinct glycosylation profiles" (2020, Nature Communications)
  • "High titers and low fucosylation of early human anti-SARS-CoV-2 IgG promote inflammation by alveolar macrophages" (2021, Science Translational Medicine)
  • "PHGDH heterogeneity potentiates cancer cell dissemination and metastasis" (2022, Nature)

The venues in which Wuhrer frequently publishes reflect an emphasis on biomedical and analytical sciences. They have contributed notably to the following journals and repositories:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Analytical Chemistry
  • Frontiers in Immunology
  • International Journal of Molecular Sciences
  • Journal of Proteome Research

Collaborative research is a significant part of Wuhrer's work. Frequent co-authors include:

  • Gestur Vidarsson
  • Jan Nouta
  • Tao Zhang
  • Guinevere S. M. Lageveen-Kammeijer
  • Simone Nicolardi

Best Publications

  • High Throughput Isolation and Glycosylation Analysis of IgG–Variability and Heritability of the IgG Glycome in Three Isolated Human Populations

    Maja Pucić;Ana Knezević;Jana Vidic;Barbara Adamczyk

  • Glycan labeling strategies and their use in identification and quantification

    Lucia Ruhaak;G. Zauner;C. Huhn;C. Bruggink

  • Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin

    Julie Bouckaert;Jenny Berglund;Mark Schembri;Erwin De Genst

  • Glycoproteomics based on tandem mass spectrometry of glycopeptides.

    Manfred Wuhrer;M. Isabel Catalina;André M. Deelder;Cornelis H. Hokke

  • MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

    Thomas Sénard;Andrea F. G. Gargano;Andrea F. G. Gargano;David Falck;Steven W. de Taeye

  • Human plasma protein N-glycosylation

    Florent Clerc;Karli R. Reiding;Bas C. Jansen;Guinevere S. M. Kammeijer

  • Loci Associated with N-Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers

    Gordan Lauc;Jennifer E. Huffman;Maja Pučić;Lina Zgaga;Lina Zgaga

  • Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity.

    Mads Delbo Larsen;Erik L. de Graaf;Myrthe E. Sonneveld;H. Rosina Plomp

  • Cotton HILIC SPE microtips for microscale purification and enrichment of glycans and glycopeptides.

    Maurice H J Selman;Mahdi Hemayatkar;André M Deelder;Manfred Wuhrer

  • IgG glycosylation analysis

    Carolin Huhn;Maurice H. J. Selman;L. Renee Ruhaak;André M. Deelder

  • High-throughput profiling of protein N-glycosylation by MALDI-TOF-MS employing linkage-specific sialic acid esterification.

    Karli R. Reiding;Dennis Blank;Dennis M. Kuijper;Dennis M. Kuijper;André M. Deelder

  • Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities.

    Gillian Dekkers;Louise Treffers;Rosina Plomp;Arthur E H Bentlage

  • Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study

    Fleur E van de Geijn;Manfred Wuhrer;Maurice Hj Selman;Sten P Willemsen

  • Regulation of autoantibody activity by the IL-23-T H 17 axis determines the onset of autoimmune disease.

    René Pfeifle;Tobias Rothe;Natacha Ipseiz;Hans U Scherer

  • Glycosylation profiling of immunoglobulin G (IgG) subclasses from human serum

    Manfred Wuhrer;Jord C. Stam;Jord C. Stam;Fleur E. van de Geijn;Carolien A. M. Koeleman

  • Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis

    Yoann Rombouts;Ewoud Ewing;Lotte A van de Stadt;Maurice H J Selman

  • Structural glycomics using hydrophilic interaction chromatography (HILIC) with mass spectrometry.

    Manfred Wuhrer;Arjen R. de Boer;André M. Deelder

  • Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes

    Albert Bondt;Albert Bondt;Yoann Rombouts;Maurice H. J. Selman;Paul J. Hensbergen

  • Protein glycosylation analysis by liquid chromatography-mass spectrometry.

    Manfred Wuhrer;André M Deelder;Cornelis H Hokke

  • N-glycomic biomarkers of biological aging and longevity: a link with inflammaging.

    Fabio Dall’Olio;Valerie Vanhooren;Cuiying Chitty Chen;P. Eline Slagboom

Frequent Co-Authors

André M. Deelder
André M. Deelder Leiden University Medical Center
Cornelis H. Hokke
Cornelis H. Hokke Leiden University Medical Center
Gestur Vidarsson
Gestur Vidarsson University of Amsterdam
Gordan Lauc
Gordan Lauc University of Zagreb
Rudolf Geyer
Rudolf Geyer University of Giessen
Theo Rispens
Theo Rispens University of Amsterdam
Rob A. E. M. Tollenaar
Rob A. E. M. Tollenaar Leiden University Medical Center
Igor Rudan
Igor Rudan University of Edinburgh
Tao Zhang
Tao Zhang Chinese Academy of Sciences
Marian Beekman
Marian Beekman Leiden University Medical Center

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