World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
20340
World Ranking
16924
National Ranking
6973

Overview

Iain D. C. Fraser is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology. Within these fields, prominent subfields of focus include Immunology, Molecular Biology, Biophysics, Epidemiology, and Infectious Diseases.

The scientist's work covers a number of main topics, with significant attention given to inflammasome and immune disorders, immune response and inflammation, and immune cells in cancer. Other topics of interest include cell image analysis techniques, immune responses and vaccinations, gut microbiota and health, and IL-33, ST2, and ILC pathways.

Among their recent scientific papers are:

  • Commensal-driven immune zonation of the liver promotes host defence (2020, Nature)
  • Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting (2024, Cell Reports)
  • Lipid regulation of NLRP3 inflammasome activity through organelle stress (2021, Trends in Immunology)
  • Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis (2023, Cell Death and Differentiation)
  • Species-Specific Endotoxin Stimulus Determines Toll-Like Receptor 4- and Caspase 11-Mediated Pathway Activation Characteristics (2021, mSystems)

Their frequent co-authors include Clinton J. Bradfield, Jing Sun, J. Liang, Sinu P John, and Michael G. Dorrington. This network highlights ongoing collaborations that contribute to their research output.

Significant venues for publication in their career include The Journal of Immunology, Nature, bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, and Nature Communications. These reflect a consistent presence in leading journals and preprint servers within the biological and immunological sciences.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Regulation of NMDA Receptors by an Associated Phosphatase-Kinase Signaling Complex

    Ryan S. Westphal;Steven J. Tavalin;Jerry W. Lin;Neal M. Alto

  • Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif.

    Daniel W. Carr;Renata E. Stofko-Hahn;Iain D C Fraser;Sarah M. Bishop

  • NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration.

    Michael G. Dorrington;Iain D. C. Fraser

  • Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain.

    Daniel W. Carr;Zachary E. Hausken;Iain D C Fraser;Renata E. Stofko-Hahn

  • A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

    Kum Joo Shin;Estelle A. Wall;Joelle R. Zavzavadjian;Leah A. Santat

  • Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.

    Daniel W. Carr;Renata E. Stofko-Hahn;Iain D C Fraser;Roger D. Cone

  • Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway

    Lily I. Jiang;Julie Collins;Richard Davis;Keng Mean Lin

  • A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events.

    Iain D. C. Fraser;Steven J. Tavalin;Linda B. Lester;Lorene K. Langeberg

  • Assembly of an A kinase-anchoring protein–β2-adrenergic receptor complex facilitates receptor phosphorylation and signaling

    Iain D.C. Fraser;Mei Cong;Jihee Kim;Emily N. Rollins

  • Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans

    Ifat Rubin-Bejerano;Iain Fraser;Paula Grisafi;Gerald R. Fink

  • Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection

    John R Grainger;Elizabeth A Wohlfert;Ivan J Fuss;Nicolas Bouladoux

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex.

    Masao Mato;Shigeo Ookawara;Atsushi Sakamoto;Eizo Aikawa

  • Suppression of LPS-induced TNF-α production in macrophages by cAMP Is mediated by PKA-AKAP95-p105

    Estelle A. Wall;Joelle R. Zavzavadjian;Mi Sook Chang;Baljinder Randhawa

  • Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79

    Mei Cong;Stephen J. Perry;Fang Tsyr Lin;Iain D. Fraser

  • Systems Biology in Immunology: A Computational Modeling Perspective ∗

    Ronald N. Germain;Martin Meier-Schellersheim;Aleksandra Nita-Lazar;Iain D.C. Fraser

  • U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies.

    Molly A. Smith;Molly A. Smith;Gaurav S. Choudhary;Andrea Pellagatti;Kwangmin Choi

  • Commensal-driven immune zonation of the liver promotes host defence

    Anita Gola;Anita Gola;Michael G. Dorrington;Emily Speranza;Claudia Sala

Frequent Co-Authors

Ronald N. Germain
Ronald N. Germain National Institute of Allergy and Infectious Diseases
John D. Scott
John D. Scott University of Washington
Melvin I. Simon
Melvin I. Simon California Institute of Technology
Steven B. Marston
Steven B. Marston National Institutes of Health
William E. Seaman
William E. Seaman University of California, San Francisco
Evelina Gatti
Evelina Gatti Aix-Marseille University
Paul C. Sternweis
Paul C. Sternweis The University of Texas Southwestern Medical Center
Clare E. Bryant
Clare E. Bryant University of Cambridge
Maurizio Molinari
Maurizio Molinari Universita della Svizzera Italiana
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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