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Biology and Biochemistry

D-Index
49
Citations
7353
World Ranking
18123
National Ranking
1244

Overview

Enno Klussmann is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with notable contributions to Medicine. The scientist's work engages deeply with Molecular Biology and Cardiology and Cardiovascular Medicine, alongside interests in Pharmacology, Pulmonary and Respiratory Medicine, and Physiology.

The focus of Klussmann's research encompasses several topics related to cardiovascular function and molecular signaling. Key areas of their study include:

  • Phosphodiesterase function and regulation
  • Cardiac electrophysiology and arrhythmias
  • Receptor Mechanisms and Signaling
  • Ion channel regulation and function
  • Ion Transport and Channel Regulation
  • Heart Failure Treatment and Management
  • Blood Pressure and Hypertension Studies

Klussmann has published extensively in several scientific venues, with frequent contributions to:

  • Circulation
  • Journal of the American Society of Nephrology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Circulation Research
  • Cells

The scientist's recent papers demonstrate an emphasis on cardiac and molecular signaling mechanisms, with notable papers including:

  • AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR, 2021, Circulation Research
  • Phosphodiesterase 3A and Arterial Hypertension, 2020, Circulation
  • Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage, 2022, Circulation
  • New aspects in cardiac L-type Ca2+ channel regulation, 2020, Biochemical Society Transactions
  • Reconstitution of β-adrenergic regulation of Ca V 1.2: Rad-dependent and Rad-independent protein kinase A mechanisms, 2021, Proceedings of the National Academy of Sciences

Collaborations form a significant part of Klussmann's work. Frequent co-authors include:

  • Anastasiia Sholokh
  • Kerstin Zühlke
  • Tamara Pallien
  • Michael Bäder
  • Sylvia Bähring

Best Publications

  • RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells *

    Martin J. Lynch;George S. Baillie;Ahmed Mohamed;Xiang Li

  • AKAP complex regulates Ca2+ re‐uptake into heart sarcoplasmic reticulum

    Birgitte Lygren;Cathrine Rein Carlson;Katja Santamaria;Valentina Lissandron

  • Protein Kinase A Anchoring Proteins Are Required for Vasopressin-mediated Translocation of Aquaporin-2 into Cell Membranes of Renal Principal Cells *

    Enno Klussmann;Kenan Maric;Burkhard Wiesner;Michael Beyermann

  • Mechanisms of protein kinase A anchoring.

    Philipp Skroblin;Solveig Grossmann;Solveig Grossmann;Gesa Schäfer;Walter Rosenthal;Walter Rosenthal

  • Isoform-Selective Susceptibility of DISC1/Phosphodiesterase-4 Complexes to Dissociation by Elevated Intracellular cAMP Levels

    Hannah Murdoch;Shaun Mackie;Daniel M Collins;Elaine V Hill

  • An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.

    Enno Klussmann;Grazia Tamma;Dorothea Lorenz;Burkhard Wiesner

  • PDE3A mutations cause autosomal dominant hypertension with brachydactyly

    Philipp G Maass;Atakan Aydin;Friedrich C Luft;Carolin Schächterle

  • Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for Its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells

    Volker Henn;Bayram Edemir;Eduard Stefan;Burkhard Wiesner

  • Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, β-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5

    Graeme B. Bolger;George S. Baillie;Xiang Li;Martin J. Lynch

  • Regulation of Aquaporin-2 Trafficking

    Pavel I. Nedvetsky;Grazia Tamma;Sven Beulshausen;Giovanna Valenti

  • Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types

    Monika Blank;Enno Klussmann;Sabine Krüger-Krasagakes;Anette Schmitt-Gräff

  • Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D Is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells

    Eduard Stefan;Burkhard Wiesner;George S. Baillie;Rustam Mollajew

  • cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI

    Grazia Tamma;Enno Klussmann;Giuseppe Procino;Maria Svelto

  • A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle.

    Pavel I. Nedvetsky;Pavel I. Nedvetsky;Eduard Stefan;Sebastian Frische;Katja Santamaria

  • Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells

    Grazia Tamma;Enno Klussmann;Kenan Maric;Klaus Aktories

  • p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway.

    Benjamin D. Sachs;George S. Baillie;Julianne R. McCall;Melissa A. Passino

  • Altered glycosylation of the MUC-1 protein core contributes to the colon carcinoma-associated increase of mucin-bound sialyl-Lewis(x) expression.

    Christoph Hanski;Kristin Drechsler;Franz-Georg Hanisch;John Sheehan

  • The mechanisms of aquaporin control in the renal collecting duct.

    E Klussmann;K Maric;W Rosenthal

  • Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

    Debbie Willoughby;Katy L Everett;Michelle Louise Halls;Jonathan Pacheco

  • MUC2 gene suppression in human colorectal carcinomas and their metastases: in vitro evidence of the modulatory role of DNA methylation

    C Hanski;E Riede;A Gratchev;H D Foss

Frequent Co-Authors

Walter Rosenthal
Walter Rosenthal Freie Universität Berlin
Miles D. Houslay
Miles D. Houslay King's College London
George S. Baillie
George S. Baillie University of Glasgow
Friedrich C. Luft
Friedrich C. Luft Charité - University Medicine Berlin
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Friedrich W. Herberg
Friedrich W. Herberg University of Kassel
Dermot M. F. Cooper
Dermot M. F. Cooper University of Cambridge
Martina Schmidt
Martina Schmidt Johannes Gutenberg University of Mainz
Gerd Krause
Gerd Krause Leibniz Institute for Neurobiology
Norbert Hubner
Norbert Hubner Max Delbrück Center for Molecular Medicine

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