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Friedrich W. Herberg

Friedrich W. Herberg

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
8739
World Ranking
12852
National Ranking
919

Overview

Friedrich W. Herberg is affiliated with the University of Kassel in Germany and has a research focus that spans several intersecting fields within biochemistry, genetics, molecular biology, and medicine. Their body of work comprises 93 publications in biochemistry, genetics, and molecular biology, as well as 46 publications related to medicine.

Their research emphasizes molecular biology, with 86 publications specifically in this subfield. Additional subfields of their work include neurology (10 publications), physiology (8 publications), cell biology (7 publications), and public health, environmental, and occupational health (6 publications).

Key topics covered in Herberg's research include:

  • Protein Kinase Regulation and GTPase Signaling
  • Parkinson's Disease Mechanisms and Treatments
  • Plant Biochemistry and Biosynthesis
  • Fungal and Yeast Genetics Research
  • Ubiquitin and Proteasome Pathways
  • Hedgehog Signaling Pathway Studies
  • Plant Gene Expression Analysis

Herberg has published in a variety of scientific venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory) - 12 publications
  • Biochemical Journal - 3 publications
  • Biophysical Journal - 3 publications
  • Proceedings of the National Academy of Sciences - 2 publications
  • Journal of Biological Chemistry - 2 publications

Notable recent papers by Herberg include:

  • "Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2," 2021, Proceedings of the National Academy of Sciences
  • "Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling," 2021, Pharmacological Reviews
  • "Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2," 2020, Frontiers in Neuroscience
  • "A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction," 2022, Nature Structural & Molecular Biology
  • "Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2," 2022, Proceedings of the National Academy of Sciences

Frequent collaborators in Herberg's research include Susan S. Taylor (26 collaborations), Daniela Bertinetti (19 collaborations), Jui-Hung Weng (14 collaborations), Jian Wu (14 collaborations), and Sven H. Schmidt (11 collaborations).

Best Publications

  • Regulatory Subunit Of Protein Kinase A: Structure of Deletion Mutant with cAMP Binding Domains

    Y. Su;W. R. G. Dostmann;F. W. Herberg;K. Durick

  • Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding.

    Friedrich W Herberg;Ariane Maleszka;Turid Eide;Lutz Vossebein

  • ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome

    Michael J. Taussig;Oda Stoevesandt;Carl A. K. Carl A K Borrebaeck;Andrew R. Bradbury

  • Recombinant Human Peroxisomal Targeting Signal Receptor PEX5 STRUCTURAL BASIS FOR INTERACTION OF PEX5 WITH PEX14

    Wolfgang Schliebs;Jürgen Saidowsky;Bogos Agianian;Gabriele Dodt

  • Neurobeachin: A Protein Kinase A-Anchoring,beige/Chediak-Higashi Protein Homolog Implicated in Neuronal Membrane Traffic

    Xiaolu Wang;Friedrich W. Herberg;Michael M. Laue;Christiane Wüllner

  • PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

    Anna Terrin;Giulietta Di Benedetto;Vanessa Pertegato;York-Fong Cheung

  • Identification of a Novel A-kinase Anchoring Protein 18 Isoform and Evidence for Its Role in the Vasopressin-induced Aquaporin-2 Shuttle in Renal Principal Cells

    Volker Henn;Bayram Edemir;Eduard Stefan;Burkhard Wiesner

  • Inhibition of T Cell Activation by Cyclic Adenosine 5′-Monophosphate Requires Lipid Raft Targeting of Protein Kinase A Type I by the A-Kinase Anchoring Protein Ezrin

    Anja Ruppelt;Randi Mosenden;Mikaela Grönholm;Einar M. Aandahl

  • Active Site Mutations Define the Pathway for the Cooperative Activation of cAMP-Dependent Protein Kinase†

    Friedrich W. Herberg;Susan S. Taylor;Wolfgang R. G. Dostmann

  • Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

    Marco Lolicato;Marco Nardini;Sabrina Gazzarrini;Stefan Möller

  • Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states.

    Friedrich W. Herberg;Sean M. Bell;Susan S. Taylor

  • The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor

    Birgit C. Viertlboeck;Sonja Schweinsberg;Matthias A. Hanczaruk;Ramona Schmitt

  • PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I.

    Bastian Zimmermann;John A. Chiorini;Yuliang Ma;Robert M. Kotin

  • Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.

    Kathrin Muda;Daniela Bertinetti;Frank Gesellchen;Jennifer Sarah Hermann

  • Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity

    Michelle J. Farquhar;Helen J. Harris;Mandy Diskar;Sarah Jones

  • Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes

    Frank Christian;Márta Szaszák;Sabine Friedl;Stephan Drewianka

  • Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase : effect of MgATP on protein-protein interactions

    Friedrich W. Herberg;Susan S. Taylor

  • Metal-protein complex-mediated transport and delivery of Ni2+ to TCR/MHC contact sites in nickel-specific human T cell activation.

    Hermann-Josef Thierse;Corinne Moulon;Yvonne Allespach;Bastian Zimmermann

  • Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase.

    Friedrich W. Herberg;Michael L. Doyle;Sarah Cox;Susan S. Taylor

  • Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries

    Lutz Kummer;Petra Parizek;Peter Rube;Bastian Millgramm

Frequent Co-Authors

Susan S. Taylor
Susan S. Taylor University of California, San Diego
Enno Klussmann
Enno Klussmann Max Delbrück Center for Molecular Medicine
Kjetil Taskén
Kjetil Taskén Oslo University Hospital
Giuseppe Melacini
Giuseppe Melacini McMaster University
marius ueffing
marius ueffing University of Tübingen
Olli Carpén
Olli Carpén University of Helsinki
Andreas Plückthun
Andreas Plückthun University of Zurich
Stefan Dübel
Stefan Dübel Technische Universität Braunschweig
Helmut E. Meyer
Helmut E. Meyer Ruhr University Bochum
Jörg D. Hoheisel
Jörg D. Hoheisel German Cancer Research Center

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