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Giuseppe Melacini

Giuseppe Melacini

D-Index & Metrics

Chemistry

D-Index
42
Citations
5585
World Ranking
17614
National Ranking
474

Overview

Giuseppe Melacini is affiliated with McMaster University in Canada and has a research focus spanning biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Their work encompasses multiple subfields, including molecular biology, physiology, neurology, spectroscopy, and computational theory and mathematics.

The scientist's research topics cover a broad range of areas, including:

  • Receptor mechanisms and signaling
  • Alzheimer's disease research and treatments
  • Phosphodiesterase function and regulation
  • Parkinson's disease mechanisms and treatments
  • Protein kinase regulation and GTPase signaling
  • Computational drug discovery methods
  • Malaria research and control

Giuseppe Melacini has authored several papers in notable scientific journals. Recent publications include:

  • Allosteric inhibition explained through conformational ensembles sampling distinct "mixed" states, 2020, Computational and Structural Biotechnology Journal
  • Catechins as Tools to Understand the Molecular Basis of Neurodegeneration, 2020, Molecules
  • Allosteric pluripotency as revealed by protein kinase A, 2020, Science Advances
  • Mechanism of allosteric inhibition in the Plasmodium falciparum cGMP-dependent protein kinase, 2020, Journal of Biological Chemistry
  • Molecular Mechanism for the Suppression of Alpha Synuclein Membrane Toxicity by an Unconventional Extracellular Chaperone, 2020, Journal of the American Chemical Society

Their work has been published frequently in several venues, with multiple publications in Biophysical Journal, Journal of Biological Chemistry, Biophysical Chemistry, Journal of Molecular Biology, and Chemical Science.

Collaborations form a significant aspect of their research, with frequent co-authorship involving several researchers. Key collaborators include Madoka Akimoto, Jinfeng Huang, Bryan VanSchouwen, Rashik Ahmed, and Jung Ah Byun.

Best Publications

  • Acetyl-Terminated and Template-Assembled Collagen-Based Polypeptides Composed of Gly-Pro-Hyp Sequences. 2. Synthesis and Conformational Analysis by Circular Dichroism, Ultraviolet Absorbance, and Optical Rotation

    Yangbo Feng;Giuseppe Melacini;Joseph P. Taulane;Murray Goodman

  • Mapping allostery through the covariance analysis of NMR chemical shifts

    Rajeevan Selvaratnam;Somenath Chowdhury;Bryan VanSchouwen;Giuseppe Melacini

  • cAMP activation of PKA defines an ancient signaling mechanism

    Rahul Das;Veronica Esposito;Mona Abu-Abed;Ganesh S. Anand

  • Understanding the molecular basis for the inhibition of the Alzheimer's Abeta-peptide oligomerization by human serum albumin using saturation transfer difference and off-resonance relaxation NMR spectroscopy.

    Julijana Milojevic;Veronica Esposito;Rahul Das;Giuseppe Melacini

  • Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting

    Ranjana Pathania;Soumaya Zlitni;Courtney Barker;Rahul Das

  • Orientation and Effects of Mastoparan X on Phospholipid Bicelles

    Jennifer A. Whiles;Robert Brasseur;Kerney J. Glover;Giuseppe Melacini

  • Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures.

    Giuseppe Melacini;Qin Zhu;Murray Goodman

  • Hydration dynamics of the collagen triple helix by NMR

    Giuseppe Melacini;Alexandre M.J.J. Bonvin;Murray Goodman;Rolf Boelens

  • Biochemical and Pharmacological Characterizations of ESI-09 Based EPAC Inhibitors: Defining the ESI-09 “Therapeutic Window”

    Yingmin Zhu;Haijun Chen;Haijun Chen;Stephen Boulton;Fang Mei

  • Human Serum Albumin Inhibits Aβ Fibrillization through a “Monomer-Competitor” Mechanism

    Julijana Milojevic;Annie Raditsis;Giuseppe Melacini

  • Signaling through dynamic linkers as revealed by PKA

    Madoka Akimoto;Rajeevan Selvaratnam;E. Tyler McNicholl;Geeta Verma

  • Stoichiometry and Affinity of the Human Serum Albumin-Alzheimer's Aβ Peptide Interactions

    Julijana Milojevic;Giuseppe Melacini

  • Molecular Mechanism for the (-)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers.

    Rashik Ahmed;Bryan VanSchouwen;Naeimeh Jafari;Xiaodan Ni

  • The Projection Analysis of NMR Chemical Shifts Reveals Extended EPAC Autoinhibition Determinants

    Rajeevan Selvaratnam;Bryan VanSchouwen;Federico Fogolari;Mohammad T. Mazhab-Jafari

  • Lanthionine−Somatostatin Analogs: Synthesis, Characterization, Biological Activity, and Enzymatic Stability Studies

    George Ösapay;Laszlo Prokai;Ho-Seung Kim;Katalin F. Medzihradszky

  • The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator.

    Christian Aem Spronk;Alexandre Mjj Bonvin;Plachikkat K Radha;Giuseppe Melacini

  • A Mechanism for the Auto-inhibition of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Opening and Its Relief by cAMP *

    Madoka Akimoto;Zaiyong Zhang;Stephen Boulton;Rajeevan Selvaratnam

  • Collagen‐based structures containing the peptoid residue N‐isobutylglycine (Nleu): Synthesis and biophysical studies of Gly‐Pro‐Nleu sequences by circular dichroism, ultraviolet absorbance, and optical rotation

    Yangbo Feng;Giuseppe Melacini;Joseph P. Taulane;Murray Goodman

  • Advances in NMR Methods To Map Allosteric Sites: From Models to Translation

    Stephen Boulton;Giuseppe Melacini

  • A refined model for the somatostatin pharmacophore : Conformational analysis of lanthionine-sandostatin analogs

    Giuseppe Melacini;Qin Zhu;George Ösapay;Murray Goodman

  • Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

    Rahul Das;Somenath Chowdhury;Mohammad T. Mazhab-Jafari;Soumita SilDas

Frequent Co-Authors

Susan S. Taylor
Susan S. Taylor University of California, San Diego
Friedrich W. Herberg
Friedrich W. Herberg University of Kassel
Robert Kaptein
Robert Kaptein Utrecht University
Rolf Boelens
Rolf Boelens Utrecht University
Richard M. Epand
Richard M. Epand McMaster University
Elizabeth A. Komives
Elizabeth A. Komives University of California, San Diego
Alexandre M. J. J. Bonvin
Alexandre M. J. J. Bonvin Utrecht University
Eric D. Brown
Eric D. Brown McMaster University
Jia Zhou
Jia Zhou The University of Texas Medical Branch at Galveston
Lori L. Burrows
Lori L. Burrows McMaster University

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