Eric D. Brown

Overview

Best Publications

• Antibiotic resistance—the need for global solutions

  Ramanan Laxminarayan;Ramanan Laxminarayan;Ramanan Laxminarayan;Adriano Duse;Chand Wattal;Anita K. M. Zaidi

  5203
  Citations

• Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori

  Richard A. Alm;Lo-See L. Ling;Donald T. Moir;Benjamin L. King

  2424
  Citations

• Antibacterial drug discovery in the resistance era

  Eric D. Brown;Gerard D. Wright

  2377
  Citations

• A Deep Learning Approach to Antibiotic Discovery

  Jonathan M. Stokes;Kevin Yang;Kyle Swanson;Wengong Jin

  2079
  Citations

• CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

  Unknown

  1873
  Citations

• A Deep Learning Approach to Antibiotic Discovery

  Unknown

  1201
  Citations

• A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

  Jason M. Peters;Alexandre Colavin;Handuo Shi;Tomasz L. Czarny

  797
  Citations

• Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

  Linda Ejim;Maya A Farha;Shannon B Falconer;Jan Wildenhain

  584
  Citations

• Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

  Eleftherios Sachlos;Ruth M. Risueño;Sarah Laronde;Zoya Shapovalova

  562
  Citations

• Drug repurposing for antimicrobial discovery

  Maya A. Farha;Eric D. Brown

  344
  Citations

• Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

  Jonathan M. Stokes;Craig R. MacNair;Bushra Ilyas;Shawn French

  336
  Citations

• MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli.

  E D Brown;E I Vivas;C T Walsh;R Kolter

  305
  Citations

• Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics.

  Craig R. MacNair;Jonathan M. Stokes;Lindsey A. Carfrae;Aline A. Fiebig-Comyn

  291
  Citations

• Collapsing the Proton Motive Force to Identify Synergistic Combinations against Staphylococcus aureus

  Maya A. Farha;Chris P. Verschoor;Dawn Bowdish;Eric D. Brown

  270
  Citations

• High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.

  Jan E. Blanchard;Nadine H. Elowe;Carly Huitema;Pascal D. Fortin

  248
  Citations

• Strategies for target identification of antimicrobial natural products

  Maya A. Farha;Eric D. Brown

  231
  Citations

• New targets and screening approaches in antimicrobial drug discovery.

  Eric D. Brown;Gerard D. Wright

  231
  Citations

• Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams.

  Maya A Farha;Alexander Leung;Edward W Sewell;Michael A D'Elia

  227
  Citations

• Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis

  Michael A. D'Elia;Kathryn E. Millar;Terry J. Beveridge;Eric D. Brown

  226
  Citations

• Helicobacter pylori Physiology Predicted from Genomic Comparison of Two Strains

  Peter Doig;Boudewijn L. de Jonge;Richard A. Alm;Eric D. Brown

  226
  Citations

• Lesions in Teichoic Acid Biosynthesis in Staphylococcus aureus Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway

  Michael A. D'Elia;Mark P. Pereira;Yu Seon Chung;Wenjun Zhao

  210
  Citations

• Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin

  John L. Marquardt;Eric D. Brown;William S. Lane;Terry M. Haley

  200
  Citations