World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
39343
World Ranking
18165
National Ranking
1430

Overview

Natalie J. Prescott is a researcher affiliated with King's College London in the United Kingdom. Their work predominantly spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology, reflecting a multidisciplinary approach to biomedical research.

The subfields of their publications include Genetics, Immunology, Molecular Biology, Epidemiology, and Surgery, indicating a broad yet focused expertise on mechanisms underlying human health and disease.

Prescott's major research topics center on inflammatory and immune-related gastrointestinal conditions. These topics include:

  • Inflammatory Bowel Disease
  • Gut microbiota and health
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Microscopic Colitis
  • Autoimmune and Inflammatory Disorders
  • Mycobacterium research and diagnosis

The scientist has contributed to a number of recent papers published in notable venues, including:

  • "Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility" (2022), published in Nature Genetics
  • "Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease" (2023), published in Science
  • "A Crohn's Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling" (2021), published in Journal of Crohn's and Colitis
  • "Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility" (2021), published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine" (2024), published in BMJ Open

Prescott often collaborates with other experts in the field, with frequent co-authors including Peter M. Irving, Christopher A Lamb, Miles Parkes, Tariq Ahmad, and John Mansfield. These collaborations highlight a network of researchers focused on gastrointestinal immunology and related molecular genetic studies.

Their research outputs have appeared mainly in journals such as Nature Genetics, Science, Journal of Crohn's and Colitis, bioRxiv (Cold Spring Harbor Laboratory), and BMJ Open, illustrating engagement with leading scientific platforms publishing advancements in genetics, immunology, and gastroenterology.

Best Publications

  • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

    Paul R. Burton;David G. Clayton;Lon R. Cardon;Nick Craddock

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

    Luke Jostins;Stephan Ripke;Rinse K Weersma;Richard H Duerr

  • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

    Jeffrey C. Barrett;Sarah Hansoul;Dan L. Nicolae;Judy H. Cho

  • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

    Andre Franke;Dermot P B McGovern;Jeffrey C. Barrett;Kai Wang

  • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

    Jochen Hampe;Andre Franke;Philip Rosenstiel;Philip Rosenstiel;Andreas Till

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Carl A. Anderson;Gabrielle Boucher;Charlie W. Lees;Andre Franke

  • Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

    Katrina M de Lange;Loukas Moutsianas;James C Lee;Christopher A Lamb

  • Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

    Paul R Burton;David G Clayton;Lon R Cardon;Nick Craddock

  • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

    Miles Parkes;Jeffrey C Barrett;Natalie J Prescott;Mark Tremelling

  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

    Nick Craddock;Matthew E. Hurles;Niall Cardin;Richard D. Pearson

  • Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

    Sergey Nejentsev;Joanna M. M. Howson;Neil M. Walker;Jeffrey Szeszko

  • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

    Jeffrey C Barrett;James C Lee;Charles W Lees;Natalie J Prescott

  • Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis

    Francesca Capon;Paola Di Meglio;Joanna Szaub;Natalie J. Prescott

  • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

    Sheila A Fisher;Mark Tremelling;Carl A Anderson;Rhian Gwilliam

  • A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.

    Natalie J. Prescott;Sheila A. Fisher;Andre Franke;Jochen Hampe

  • High-density mapping of the MHC identifies a shared role for HLA-DRB1∗01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

    Philippe Goyette;Gabrielle Boucher;Dermot Mallon;Eva Ellinghaus

  • Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35

    Mary L. Marazita;Jeffrey C. Murray;Andrew C. Lidral;Mauricio Arcos-Burgos

  • Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein

    Lesley McGregor;Vile Makela;Susan M. Darling;Susan M. Darling;Sofia Vrontou

  • Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota.

    Jane L. Benjamin;Charlotte R.H. Hedin;Andreas Koutsoumpas;Siew C. Ng;Siew C. Ng

  • Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease

    James C Lee;Daniele Biasci;Rebecca Roberts;Richard B Gearry

Frequent Co-Authors

Christopher G. Mathew
Christopher G. Mathew King's College London
Jeremy D. Sanderson
Jeremy D. Sanderson Guy's and St Thomas' NHS Foundation Trust
Cathryn M. Lewis
Cathryn M. Lewis King's College London
Jack Satsangi
Jack Satsangi University of Oxford
Miles Parkes
Miles Parkes University of Cambridge
Alastair Forbes
Alastair Forbes University of Tartu
Tariq Ahmad
Tariq Ahmad Yale University
Derek P. Jewell
Derek P. Jewell University of Oxford
Carl A. Anderson
Carl A. Anderson Wellcome Sanger Institute
Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge

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