Sharron H. Francis

Overview

Best Publications

• cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

  Sharron H. Francis;Jennifer L. Busch;Jackie D. Corbin

  1239
  Citations

• Cyclic nucleotide phosphodiesterases: relating structure and function.

  Francis Sh;Turko;Corbin Jd

  809
  Citations

• Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

  Sharron H. Francis;Mitsi A. Blount;Jackie D. Corbin

  802
  Citations

• Cyclic GMP phosphodiesterase-5: target of sildenafil.

  Jackie D. Corbin;Sharron H. Francis

  725
  Citations

• Structure and function of cyclic nucleotide-dependent protein kinases

  Sharron H. Francis;Jackie D. Corbin

  649
  Citations

• Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action

  Sharron H. Francis;Jackie D. Corbin

  433
  Citations

• Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.

  Hang Jiang;J. L. Colbran;S. H. Francis;J. D. Corbin

  387
  Citations

• Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities.

  Jackie D. Corbin;Illarion V. Turko;Alfreda Beasley;Sharron H. Francis

  371
  Citations

• Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP.

  L. R. Forte;P. K. Thorne;S. L. Eber;W. J. Krause

  350
  Citations

• Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.

  Kate Loughney;Teresa R Hill;Vincent A Florio;Lothar Uher

  331
  Citations

• Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

  M K Thomas;S H Francis;J D Corbin

  323
  Citations

• Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.

  S H Francis;B D Noblett;B W Todd;J N Wells

  314
  Citations

• Characterization of a novel cGMP binding protein from rat lung.

  S H Francis;T M Lincoln;J D Corbin

  275
  Citations

• Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds.

  Illarion V. Turko;Stephen A. Ballard;Sharron H. Francis;Jackie D. Corbin

  269
  Citations

• High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors.

  Jackie D. Corbin;Alfreda Beasley;Mitsi A. Blount;Sharron H. Francis

  260
  Citations

• The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

  L M McAllister-Lucas;W K Sonnenburg;A Kadlecek;D Seger

  251
  Citations

• Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction

  Jackie D Corbin;Sharron H Francis;David J Webb

  236
  Citations

• Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation

  Mitsi A. Blount;Alfreda Beasley;Roya Zoraghi;Konjeti R. Sekhar

  232
  Citations

• Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

  M K Thomas;S H Francis;J D Corbin

  228
  Citations

• Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta.

  L Wolfe;J D Corbin;S H Francis

  218
  Citations