What is she best known for?
The fields of study she is best known for:
Her scientific interests lie mostly in Biochemistry, Phosphodiesterase, Phosphodiesterase 3, PDE10A and CGMP binding.
Cyclic nucleotide, Phosphorylation, Kinase, Protein kinase A and cGMP-dependent protein kinase are the subjects of her Biochemistry studies.
Her research integrates issues of Subcellular localization and Alternative splicing in her study of Phosphorylation.
Specifically, her work in Phosphodiesterase is concerned with the study of Cyclic nucleotide phosphodiesterase.
Sharron H. Francis has researched CGMP binding in several fields, including Amino acid, Zaprinast and Pharmacology.
Her research in Pharmacology intersects with topics in PDE5 drug design, cGMP-specific phosphodiesterase type 5 and Milrinone.
Her most cited work include:
- cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action (631 citations)
- Cyclic nucleotide phosphodiesterases: relating structure and function. (512 citations)
- Cyclic GMP phosphodiesterase-5: target of sildenafil. (441 citations)
What are the main themes of her work throughout her whole career to date?
Sharron H. Francis mainly focuses on Biochemistry, Phosphodiesterase, Protein kinase A, CGMP binding and cGMP-dependent protein kinase.
Her work in Enzyme, Phosphodiesterase 3, Kinase, PDE10A and Phosphorylation are all subfields of Biochemistry research.
Her Phosphodiesterase study combines topics in areas such as Amino acid, Nucleotide, Cyclic nucleotide and Stereochemistry.
Her Protein kinase A research focuses on Molecular biology and how it connects with Mutant.
Her studies in cGMP-dependent protein kinase integrate themes in fields like Kinase activity and Cyclic GMP-Dependent Protein Kinases.
In her study, which falls under the umbrella issue of Allosteric regulation, Pharmacology and Vardenafil is strongly linked to cGMP-specific phosphodiesterase type 5.
She most often published in these fields:
- Biochemistry (54.29%)
- Phosphodiesterase (37.86%)
- Protein kinase A (27.86%)
What were the highlights of her more recent work (between 2008-2016)?
- Phosphodiesterase (37.86%)
- Biochemistry (54.29%)
- Phosphodiesterase 3 (20.00%)
In recent papers she was focusing on the following fields of study:
Her primary areas of study are Phosphodiesterase, Biochemistry, Phosphodiesterase 3, Enzyme and Phosphorylation.
She combines subjects such as Pharmacology, Stereochemistry, Allosteric regulation and Cell biology with her study of Phosphodiesterase.
Her biological study spans a wide range of topics, including Sildenafil and PDE5 drug design.
Her study in the fields of Cyclic nucleotide and Cyclic gmp under the domain of Biochemistry overlaps with other disciplines such as Phosphodiester bond.
She frequently studies issues relating to PDE10A and Phosphodiesterase 3.
Her cGMP-dependent protein kinase and Protein kinase A study are her primary interests in Phosphorylation.
Between 2008 and 2016, her most popular works were:
- cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action (631 citations)
- Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions (420 citations)
- cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium. (61 citations)
In her most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Phosphodiesterase, Phosphodiesterase 3, Cell biology, Pharmacology and Enzyme.
Her Phosphodiesterase research is within the category of Biochemistry.
Her work on Protein kinase A and cGMP-dependent protein kinase as part of general Cell biology research is often related to Adenosine receptor, thus linking different fields of science.
Her Pharmacology study which covers Internal medicine that intersects with PDE10A.
Her Enzyme research incorporates elements of Gene, Gene isoform, Small molecule, Selectivity and Computational biology.
The study incorporates disciplines such as Tadalafil, Vardenafil, Purine, Isozyme and Allosteric regulation in addition to Cyclic nucleotide.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
