Her scientific interests lie mostly in Biochemistry, Phosphodiesterase, Phosphodiesterase 3, PDE10A and CGMP binding. Cyclic nucleotide, Phosphorylation, Kinase, Protein kinase A and cGMP-dependent protein kinase are the subjects of her Biochemistry studies. Her research integrates issues of Subcellular localization and Alternative splicing in her study of Phosphorylation.
Specifically, her work in Phosphodiesterase is concerned with the study of Cyclic nucleotide phosphodiesterase. Sharron H. Francis has researched CGMP binding in several fields, including Amino acid, Zaprinast and Pharmacology. Her research in Pharmacology intersects with topics in PDE5 drug design, cGMP-specific phosphodiesterase type 5 and Milrinone.
Sharron H. Francis mainly focuses on Biochemistry, Phosphodiesterase, Protein kinase A, CGMP binding and cGMP-dependent protein kinase. Her work in Enzyme, Phosphodiesterase 3, Kinase, PDE10A and Phosphorylation are all subfields of Biochemistry research. Her Phosphodiesterase study combines topics in areas such as Amino acid, Nucleotide, Cyclic nucleotide and Stereochemistry.
Her Protein kinase A research focuses on Molecular biology and how it connects with Mutant. Her studies in cGMP-dependent protein kinase integrate themes in fields like Kinase activity and Cyclic GMP-Dependent Protein Kinases. In her study, which falls under the umbrella issue of Allosteric regulation, Pharmacology and Vardenafil is strongly linked to cGMP-specific phosphodiesterase type 5.
Her primary areas of study are Phosphodiesterase, Biochemistry, Phosphodiesterase 3, Enzyme and Phosphorylation. She combines subjects such as Pharmacology, Stereochemistry, Allosteric regulation and Cell biology with her study of Phosphodiesterase. Her biological study spans a wide range of topics, including Sildenafil and PDE5 drug design.
Her study in the fields of Cyclic nucleotide and Cyclic gmp under the domain of Biochemistry overlaps with other disciplines such as Phosphodiester bond. She frequently studies issues relating to PDE10A and Phosphodiesterase 3. Her cGMP-dependent protein kinase and Protein kinase A study are her primary interests in Phosphorylation.
The scientist’s investigation covers issues in Phosphodiesterase, Phosphodiesterase 3, Cell biology, Pharmacology and Enzyme. Her Phosphodiesterase research is within the category of Biochemistry. Her work on Protein kinase A and cGMP-dependent protein kinase as part of general Cell biology research is often related to Adenosine receptor, thus linking different fields of science.
Her Pharmacology study which covers Internal medicine that intersects with PDE10A. Her Enzyme research incorporates elements of Gene, Gene isoform, Small molecule, Selectivity and Computational biology. The study incorporates disciplines such as Tadalafil, Vardenafil, Purine, Isozyme and Allosteric regulation in addition to Cyclic nucleotide.
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cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
Sharron H. Francis;Jennifer L. Busch;Jackie D. Corbin.
Pharmacological Reviews (2010)
Cyclic nucleotide phosphodiesterases: relating structure and function.
Sharron H. Francis;Illarion V. Turko;Jackie D. Corbin.
Progress in Nucleic Acid Research and Molecular Biology (2001)
Cyclic GMP phosphodiesterase-5: target of sildenafil.
Jackie D. Corbin;Sharron H. Francis.
Journal of Biological Chemistry (1999)
Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions
Sharron H. Francis;Mitsi A. Blount;Jackie D. Corbin.
Physiological Reviews (2011)
Structure and function of cyclic nucleotide-dependent protein kinases
Sharron H. Francis;Jackie D. Corbin.
Annual Review of Physiology (1994)
Cyclic Nucleotide-Dependent Protein Kinases: Intracellular Receptors for cAMP and cGMP Action
Sharron H. Francis;Jackie D. Corbin.
Critical Reviews in Clinical Laboratory Sciences (1999)
Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.
Hang Jiang;J. L. Colbran;S. H. Francis;J. D. Corbin.
Journal of Biological Chemistry (1992)
Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities.
Jackie D. Corbin;Illarion V. Turko;Alfreda Beasley;Sharron H. Francis.
FEBS Journal (2000)
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.
Kate Loughney;Teresa R Hill;Vincent A Florio;Lothar Uher.
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase.
S H Francis;B D Noblett;B W Todd;J N Wells.
Molecular Pharmacology (1988)
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