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Alexander Pfeifer

Alexander Pfeifer

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
20337
World Ranking
4576
National Ranking
338

Overview

Alexander Pfeifer is a researcher affiliated with the University of Bonn in Germany. Their work primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific emphasis on Physiology and Molecular Biology. Additional focus areas include Epidemiology, Cardiology and Cardiovascular Medicine, and Immunology.

The main topics of Pfeifer's research encompass Adipose Tissue and Metabolism, Adipokines, Inflammation, and Metabolic Diseases, as well as Lipid Metabolism and Biosynthesis. Further areas of study include Cardiovascular Disease and Adiposity, Cardiac Valve Diseases and Treatments, Receptor Mechanisms and Signaling, and Extracellular Vesicles in Disease.

Frequently publishing their work in notable scientific venues, Pfeifer has contributed significantly to bioRxiv (Cold Spring Harbor Laboratory) with 12 publications. Other venues with multiple publications include Communications Biology, Molecular Metabolism, Nature Metabolism, and The FASEB Journal.

Among recent publications authored or co-authored by Pfeifer are the following papers:

  • "Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine," 2022, Nature
  • "Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis," 2021, Cell
  • "Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity," 2020, Cell Metabolism
  • "Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs," 2020, Molecular Cell
  • "Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity," 2022, Microbiome

Frequent collaborators in Pfeifer's research include Staffan Hildebrand, Thorsten Gnad, Dagmar Wachten, Jöerg Heeren, and Felix Jansen.

Best Publications

  • Neuronal fate determinants of adult olfactory bulb neurogenesis.

    Michael A Hack;Armen Saghatelyan;Antoine de Chevigny;Alexander Pfeifer

  • Transgenesis by lentiviral vectors: Lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

    Alexander Pfeifer;Masahito Ikawa;Yelena Dayn;Inder M. Verma

  • Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice.

    Marc Freichel;Suk Hyo Suh;Alexander Pfeifer;Ulli Schweig

  • Defective smooth muscle regulation in cGMP kinase I‐deficient mice

    Alexander Pfeifer;Peter Klatt;Steffen Massberg;Lars Ny

  • Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-κB signaling

    Ramin Massoumi;Katarzyna Chmielarska;Katharina Hennecke;Alexander Pfeifer

  • Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia

    Wilhelm Roell;Thorsten Lewalter;Philipp Sasse;Yvonne N. Tallini

  • Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

    Takao Sakai;Shaohua Li;Denitsa Docheva;Carsten Grashoff

  • Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.

    Alexander Pfeifer;Attila Aszódi;Ursula Seidler;Peter Ruth

  • Gene Therapy: Promises and Problems

    Alexander Pfeifer;Inder M. Verma

  • Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors.

    Thorsten Gnad;Saskia Scheibler;Ivar von Kügelgen;Camilla Scheele

  • Efficient transgenesis in farm animals by lentiviral vectors

    Andreas Hofmann;Barbara Kessler;Sonja Ewerling;Myriam Weppert

  • Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission.

    Doreen Muth;Doreen Muth;Victor Max Corman;Victor Max Corman;Hanna Roth;Tabea Binger

  • Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.

    Claudia Seisenberger;Verena Specht;Andrea Welling;Josef Platzer

  • Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3

    Martin Biel;Mathias Seeliger;Alexander Pfeifer;Konrad Kohler

  • The vasodilator-stimulated phosphoprotein (VASP) is involved in cGMP- and cAMP-mediated inhibition of agonist-induced platelet aggregation, but is dispensable for smooth muscle function.

    Attila Aszódi;Alexander Pfeifer;Alexander Pfeifer;Marianne Ahmad;Martin Glauner

  • Mechanisms of NO/cGMP-Dependent Vasorelaxation

    Matthias Sausbier;Rudolf Schubert;Viktor Voigt;Christoph Hirneiss

  • Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells.

    Dilek Colak;Tetsuji Mori;Monika S. Brill;Alexander Pfeifer

  • Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I

    Steffen Massberg;Matthias Sausbier;Peter Klatt;Markus Bauer

  • miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

    Yong Chen;Franziska Siegel;Stefanie Kipschull;Bodo Haas;Bodo Haas

  • Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo.

    Alexander Pfeifer;Eugene P. Brandon;Neeltje Kootstra;Fred H. Gage

Frequent Co-Authors

Franz Hofmann
Franz Hofmann Technical University of Munich
Bernd K. Fleischmann
Bernd K. Fleischmann University of Bonn
Eckhard Wolf
Eckhard Wolf Ludwig-Maximilians-Universität München
Reinhard Fässler
Reinhard Fässler Max Planck Society
Attila Aszódi
Attila Aszódi Ludwig-Maximilians-Universität München
Andreas Hofmann
Andreas Hofmann University of Melbourne
Peter Ruth
Peter Ruth University of Tübingen
Martin Biel
Martin Biel Ludwig-Maximilians-Universität München
Inder M. Verma
Inder M. Verma Salk Institute for Biological Studies
Karl Werdan
Karl Werdan Martin Luther University Halle-Wittenberg

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