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D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
12879
World Ranking
9306
National Ranking
682

Overview

Marc Freichel is affiliated with Heidelberg University in Germany and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields including molecular biology, sensory systems, physiology, immunology, and cardiology and cardiovascular medicine.

The core focus of Freichel's work involves ion channels and receptors, as well as calcium signaling and nucleotide metabolism. Their investigations also cover topics related to atherosclerosis and cardiovascular diseases, adipokines, inflammation, and metabolic diseases, ion channel regulation and function, neurobiology and insect physiology research, and CRISPR and genetic engineering.

Freichel has published numerous papers in notable scientific venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory) with 12 publications, the Journal of Molecular and Cellular Cardiology and Cell Calcium with four publications each, as well as Frontiers in Immunology and the Proceedings of the National Academy of Sciences, each with three publications.

Some recent significant papers by Freichel include the following:

  • Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis, 2020, Gastroenterology
  • STING orchestrates the neuronal inflammatory stress response in multiple sclerosis, 2024, Cell
  • Odontoblast TRPC5 channels signal cold pain in teeth, 2021, Science Advances
  • Enhancing mitochondrial activity in neurons protects against neurodegeneration in a mouse model of multiple sclerosis, 2021, eLife
  • Analysis of Mrgprb2 Receptor-Evoked Ca2+ Signaling in Bone Marrow Derived (BMMC) and Peritoneal (PMC) Mast Cells of TRPC-Deficient Mice, 2020, Frontiers in Immunology

Their collaborative network features frequent coauthors such as Rebekka Medert, Volodymyr Tsvilovskyy, Roger Ottenheijm, Juan E. Camacho Londoño, and Angela Wirth, with collaboration counts ranging from 12 to 22 publications each.

Freichel's research continues to contribute to the understanding of cellular signaling processes and their implications for disease mechanisms, particularly in relation to ion channels and inflammatory responses.

Best Publications

  • Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4-/- mice.

    Marc Freichel;Suk Hyo Suh;Alexander Pfeifer;Ulli Schweig

  • Impairment of Store-Operated Ca2+ Entry in TRPC4-/- Mice Interferes With Increase in Lung Microvascular Permeability

    Chinnaswamy Tiruppathi;Marc Freichel;Stephen M. Vogel;Biman C. Paria

  • Trp12, a novel Trp related protein from kidney.

    Ulrich Wissenbach;Matthias Bödding;Marc Freichel;Veit Flockerzi

  • TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination

    Jana Hartmann;Elena Dragicevic;Helmuth Adelsberger;Horst A. Henning

  • A novel capacitative calcium entry channel expressed in excitable cells

    Stephan Philipp;Joerg Hambrecht;Leonid Braslavski;Gregor Schroth

  • Voltage Dependence of the Ca2+-activated Cation Channel TRPM4

    Bernd Nilius;Jean Prenen;Guy Droogmans;Thomas Voets

  • A mammalian capacitative calcium entry channel homologous to Drosophila TRP and TRPL.

    S. Philipp;A. Cavalié;M. Freichel;U. Wissenbach

  • Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4.

    Rudi Vennekens;Rudi Vennekens;Jenny Olausson;Marcel Meissner;Wilhelm Bloch

  • Melanopsin signalling in mammalian iris and retina

    T. Xue;M. T H Do;M. T H Do;A. Riccio;Z. Jiang

  • De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury.

    Volodymyr Gerzanich;S Kyoon Woo;Rudi Vennekens;Orest Tsymbalyuk

  • TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

    Benjamin Schattling;Karin Steinbach;Karin Steinbach;Edda Thies;Martin Kruse

  • Deletion of TRPC4 and TRPC6 in Mice Impairs Smooth Muscle Contraction and Intestinal Motility In Vivo.

    Volodymyr V. Tsvilovskyy;Alexander V. Zholos;Thomas Aberle;Stephan E. Philipp

  • Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice

    Norbert Weissmann;Akylbek Sydykov;Hermann Kalwa;Hermann Kalwa;Ursula Storch

  • Isoform-specific Inhibition of TRPC4 Channel by Phosphatidylinositol 4,5-Bisphosphate

    Ken Ichi Otsuguro;Jisen Tang;Yufang Tang;Rui Xiao

  • Expression of a Calcium-Sensing Receptor in a Human Medullary Thyroid Carcinoma Cell Line and Its Contribution to Calcitonin Secretion*

    M Freichel;A Zink-Lorenz;A Holloschi;M Hafner

  • Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

    Sebastian Brings;Thomas Fleming;Thomas Fleming;Marc Freichel;Martina U. Muckenthaler

  • Primary structure and functional expression of a cyclic nucleotidegated channel from rabbit aorta

    Martin Biel;Wolfram Altenhofen;Roger Hullin;Jost Ludwig

  • TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

    Kathryn Quick;Jing Zhao;Niels Eijkelkamp;John E. Linley

  • Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice

    Ilka Mathar;Rudi Vennekens;Marcel Meissner;Frieder Kees

  • The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor

    Steven D. Broadbent;Steven D. Broadbent;Mohabir Ramjeesingh;Christine E. Bear;Barry E. Argent

Frequent Co-Authors

Veit Flockerzi
Veit Flockerzi Saarland University
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Bernd Nilius
Bernd Nilius KU Leuven
Alexander Dietrich
Alexander Dietrich Ludwig-Maximilians-Universität München
Thomas Voets
Thomas Voets KU Leuven
Manuel A. Friese
Manuel A. Friese Universität Hamburg
Peter P. Nawroth
Peter P. Nawroth Heidelberg University
Richard A. Flavell
Richard A. Flavell Yale University
Franz Hofmann
Franz Hofmann Technical University of Munich
Oliver Kretz
Oliver Kretz Universität Hamburg

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