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Biology and Biochemistry

D-Index
56
Citations
9153
World Ranking
14640
National Ranking
133

Overview

Klaus Groschner is affiliated with the Medical University of Graz in Austria. Their research focuses primarily on ion channels and receptors, with significant contributions to neuroscience and biochemistry, genetics, and molecular biology.

The scientist's work spans multiple areas of study including sensory systems, molecular biology, cellular and molecular neuroscience, cancer research, and physiology. This interdisciplinary approach is reflected in the range of topics they have explored, such as ion channel regulation and function, lipid membrane structure and behavior, pancreatic function and diabetes, as well as cancer, hypoxia, and metabolism.

Frequent publication venues for Klaus Groschner include Biophysical Journal, Cell Calcium, Frontiers in Immunology, iScience, and Scientific Reports. These journals indicate a consistent engagement with experimental and physiological research contexts.

Collaborative efforts are a notable aspect of Groschner's scientific output. Frequent co-authors include Oleksandra Tiapko, Thomas Stockner, Bernadett Bacsa, Roland Malli, and Hazel Erkan-Candag.

Recent significant publications by Klaus Groschner cover a range of topics related to molecular and cellular physiology:

  • Pharmaco-Optogenetic Targeting of TRPC Activity Allows for Precise Control Over Mast Cell NFAT Signaling, 2020, Frontiers in Immunology
  • Potassium ions promote hexokinase-II dependent glycolysis, 2021, iScience
  • Mechanisms and significance of Ca2+ entry through TRPC channels, 2020, Current Opinion in Physiology
  • Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state, 2022, EMBO Reports
  • TRIC-A shapes oscillatory Ca2+ signals by interaction with STIM1/Orai1 complexes, 2020, PLoS Biology

Best Publications

  • Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

    Martin Muik;Irene Frischauf;Isabella Derler;Marc Fahrner

  • A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

    Martin Muik;Marc Fahrner;Isabella Derler;Rainer Schindl

  • Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels.

    Birgit Lintschinger;Monika Balzer-Geldsetzer;Tyagarajan Baskaran;Wolfgang F. Graier

  • STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

    Martin Muik;Marc Fahrner;Rainer Schindl;Peter Stathopulos

  • TRPC3 and TRPC4 Associate to Form a Redox-sensitive Cation Channel EVIDENCE FOR EXPRESSION OF NATIVE TRPC3-TRPC4 HETEROMERIC CHANNELS IN ENDOTHELIAL CELLS

    Michael Poteser;Annarita Graziani;Christian Rosker;Petra Eder

  • Ca2+ signaling by TRPC3 involves Na+ entry and local coupling to the Na+/Ca2+ exchanger

    Christian Rosker;Annarita Graziani;Michael Lukas;Petra Eder

  • Trp proteins form store-operated cation channels in human vascular endothelial cells

    Klaus Groschner;Susanne Hingel;Birgit Lintschinger;Monika Balzer

  • Novel pyrazole compounds for pharmacological discrimination between receptor‐operated and store‐operated Ca2+ entry pathways

    H Schleifer;B Doleschal;M Lichtenegger;R Oppenrieder

  • Molecular Analysis of a Store-operated and 2-Acetyl-sn-glycerol-sensitive Non-selective Cation Channel HETEROMERIC ASSEMBLY OF TRPC1-TRPC3

    Xibao Liu;Bidhan C. Bandyopadhyay;Brij B. Singh;Klaus Groschner

  • Molecular Determinants of the Coupling between STIM1 and Orai Channels DIFFERENTIAL ACTIVATION OF Orai1–3 CHANNELS BY A STIM1 COILED-COIL MUTANT

    Irene Frischauf;Martin Muik;Isabella Derler;Judith Bergsmann

  • Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells.

    Monika Balzer;Birgit Lintschinger;Klaus Groschner

  • 2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size

    Rainer Schindl;Judith Bergsmann;Irene Frischauf;Isabella Derler

  • Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line

    Chouyang Li;Simin Rezania;Sarah Kammerer;Armin Andreas Sokolowski

  • Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.

    Helmut Bischof;Markus Rehberg;Sarah Stryeck;Katharina Artinger

  • A Ca2+ Release-activated Ca2+ (CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels

    Isabella Derler;Marc Fahrner;Martin Muik;Barbara Lackner

  • INTRACELLULAR CA2+ INHIBITS SMOOTH MUSCLE L-TYPE CA2+ CHANNELS BY ACTIVATION OF PROTEIN PHOSPHATASE TYPE 2B AND BY DIRECT INTERACTION WITH THE CHANNEL

    Klaus Schuhmann;Christoph Romanin;Werner Baumgartner;Klaus Groschner

  • Functional Consequences of P/Q-type Ca2+Channel Cav2.1 Missense Mutations Associated with Episodic Ataxia Type 2 and Progressive Ataxia

    Edwin Wappl;Alexandra Koschak;Michael Poteser;Martina J. Sinnegger

  • Current modulation and membrane targeting of the calcium channel α1C subunit are independent functions of the β subunit

    Uli Gerster;Birgit Neuhuber;Klaus Groschner;Jörg Striessnig

  • Na+/Ca2+ Exchange Facilitates Ca2+-dependent Activation of Endothelial Nitric-oxide Synthase

    Margot Teubl;Klaus Groschner;Sepp-Dieter Kohlwein;Bernd Mayer

  • Trp proteins form store-operated cation channels in human vascular endothelial cells (FEBS 20791) (FEBS Letters 437 (1998) (101-106) PII: S0014579398012125)

    K. Groschner;S. Hingel;B. Lintschinger;M. Balzer

Frequent Co-Authors

Christoph Romanin
Christoph Romanin Johannes Kepler University of Linz
Wolfgang F. Graier
Wolfgang F. Graier Medical University of Graz
Roland Malli
Roland Malli Medical University of Graz
C. Oliver Kappe
C. Oliver Kappe University of Graz
Kurt Schmidt
Kurt Schmidt University of Graz
Bernd Mayer
Bernd Mayer University of Graz
Michael X. Zhu
Michael X. Zhu The University of Texas Health Science Center at Houston
Sepp D. Kohlwein
Sepp D. Kohlwein University of Graz
Burkert Pieske
Burkert Pieske Charité - University Medicine Berlin
Ernst Malle
Ernst Malle Medical University of Graz

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