World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
20341
World Ranking
4799
National Ranking
2318

Overview

Michael X. Zhu is affiliated with The University of Texas Health Science Center at Houston in the United States. Their research spans multiple fields, including neuroscience, medicine, and biochemistry, genetics, and molecular biology. Within these disciplines, Zhu has contributed notably to subfields such as molecular biology, sensory systems, cellular and molecular neuroscience, physiology, and cognitive neuroscience.

The main topics of their research work concentrate on ion channels and receptors, ion channel regulation and function, and neuroscience and neuropharmacology research. Additional areas of investigation include neurobiology and insect physiology research, phytochemicals and antioxidant activities, herbal medicine research studies, and pain mechanisms and treatments.

Zhu has published in a variety of scientific venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • British Journal of Pharmacology
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Journal of Biological Chemistry

Collaboration plays an important role in their work, with several frequent co-authors including:

  • Jinbin Tian
  • Tian-Le Xu
  • Qiaochu Wang
  • Jaepyo Jeon
  • Ye Yu

Recent scientific papers authored or co-authored by Michael X. Zhu illustrate their focus and scope. Selected publications include:

  • THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels, 2021, British Journal of Pharmacology
  • TRPC channels: Structure, function, regulation and recent advances in small molecular probes, 2020, Pharmacology & Therapeutics
  • The Concise Guide to PHARMACOLOGY 2023/24: Ion channels, 2023, British Journal of Pharmacology
  • DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation, 2020, Science Advances
  • Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis, 2020, Nature Communications

Best Publications

  • NAADP mobilizes calcium from acidic organelles through two-pore channels

    Peter J. Calcraft;Margarida Ruas;Zui Pan;Xiaotong Cheng

  • A Unified Nomenclature for the Superfamily of TRP Cation Channels

    Craig Montell;Lutz Birnbaumer;Veit Flockerzi;René J. Bindels

  • 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.

    Hong Zhen Hu;Qihai Gu;Chunbo Wang;Craig K. Colton

  • Control of Pollen Tube Tip Growth by a Rop GTPase–Dependent Pathway That Leads to Tip-Localized Calcium Influx

    Hai Li;Yakang Lin;Rachel M. Heath;Michael X. Zhu

  • TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

    Xiang Wang;Xiaoli Zhang;Xian Ping Dong;Mohammad Samie

  • Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry

    Guylain Boulay;Darren M. Brown;Ning Qin;Meisheng Jiang

  • Identification of Common Binding Sites for Calmodulin and Inositol 1,4,5-Trisphosphate Receptors on the Carboxyl Termini of Trp Channels

    Jisen Tang;Yakang Lin;Zongming Zhang;Svetlana Tikunova

  • Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels.

    Birgit Lintschinger;Monika Balzer-Geldsetzer;Tyagarajan Baskaran;Wolfgang F. Graier

  • Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels

    Yanhong Liao;Christian Erxleben;Joel Abramowitz;Veit Flockerzi

  • The N-Terminal Domain of the IP3 Receptor Gates Store-Operated hTrp3 Channels

    Kirill Kiselyov;Gregory A Mignery;Michael X Zhu;Shmuel Muallem

  • Trp1, a Candidate Protein for the Store-operated Ca2+Influx Mechanism in Salivary Gland Cells

    Xibao Liu;Weiching Wang;Brij B. Singh;Timothy Lockwich

  • A role for Orai in TRPC-mediated Ca2+ entry suggests that a TRPC:Orai complex may mediate store and receptor operated Ca2+ entry

    Yanhong Liao;Nicholas W. Plummer;Margaret D. George;Joel Abramowitz

  • Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.

    Bernd Nilius;Jean Prenen;Jisen Tang;Chunbo Wang

  • Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

    Yong Zhou;Ching On Wong;Kwang Jin Cho;Dharini Van Der Hoeven

  • Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

    Margarida Ruas;Katja Rietdorf;Abdelilah Arredouani;Lianne C. Davis

  • Association of Mammalian Trp4 and Phospholipase C Isozymes with a PDZ Domain-containing Protein, NHERF

    Yufang Tang;Jisen Tang;Zhangguo Chen;Claudia Trost

  • Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel.

    Sheila R. Hassock;Michael X. Zhu;Michael X. Zhu;Michael X. Zhu;Claudia Trost;Claudia Trost;Claudia Trost;Veit Flockerzi;Veit Flockerzi;Veit Flockerzi

  • Multiple roles of calmodulin and other Ca 2+ -binding proteins in the functional regulation of TRP channels

    Michael Xi Zhu

  • Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain

    Zongming Zhang;Jisen Tang;Svetlana Tikunova;J. David Johnson

  • Zinc activates damage-sensing TRPA1 ion channels

    Hongzhen Hu;Michael Bandell;Matt J Petrus;Michael X Zhu

Frequent Co-Authors

Min Li
Min Li Chinese Academy of Sciences
Antony Galione
Antony Galione University of Oxford
Jianjie Ma
Jianjie Ma The Ohio State University
John Parrington
John Parrington University of Oxford
Lutz Birnbaumer
Lutz Birnbaumer National Institutes of Health
Veit Flockerzi
Veit Flockerzi Saarland University
David E. Clapham
David E. Clapham Howard Hughes Medical Institute
Christoph Romanin
Christoph Romanin Johannes Kepler University of Linz
Indu S. Ambudkar
Indu S. Ambudkar National Institutes of Health
Marc Freichel
Marc Freichel Heidelberg University

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