His primary areas of investigation include Cell biology, Biochemistry, Endoplasmic reticulum, Calcium and STIM2. His Cell biology research integrates issues from HEK 293 cells, Transient receptor potential channel and Membrane protein. His work investigates the relationship between Biochemistry and topics such as Biophysics that intersect with problems in Diacylglycerol kinase.
He focuses mostly in the field of Endoplasmic reticulum, narrowing it down to topics relating to Calcium signaling and, in certain cases, Marine toxin. His STIM2 research is multidisciplinary, incorporating elements of Stromal Interaction Molecule 2 and Cell calcium. His ORAI1 study is concerned with the field of Voltage-dependent calcium channel as a whole.
Donald L. Gill mainly focuses on Cell biology, STIM1, Endoplasmic reticulum, ORAI1 and Biophysics. His research integrates issues of Receptor and Calcium, Voltage-dependent calcium channel in his study of Cell biology. When carried out as part of a general STIM1 research project, his work on STIM2 is frequently linked to work in Coupling, therefore connecting diverse disciplines of study.
As a member of one scientific family, he mostly works in the field of Endoplasmic reticulum, focusing on Cytosol and, on occasion, Mitochondrion. In his research on the topic of ORAI1, TRPC1 is strongly related with Calcium channel. His biological study deals with issues like Biochemistry, which deal with fields such as Calcium metabolism.
His main research concerns ORAI1, Endoplasmic reticulum, STIM1, Biophysics and Cell biology. His ORAI1 research is multidisciplinary, incorporating elements of Extracellular, Transmembrane domain and Cytosol. He interconnects Secretion, Protein–protein interaction and Calcium signaling in the investigation of issues within Endoplasmic reticulum.
His STIM1 research integrates issues from Biomedical engineering and Förster resonance energy transfer. His studies in Biophysics integrate themes in fields like Allosteric regulation, Calcium channel and Voltage-dependent calcium channel. His Cell biology study integrates concerns from other disciplines, such as HEK 293 cells, Receptor and Calcium.
Donald L. Gill mainly investigates ORAI1, Cell biology, Endoplasmic reticulum, STIM1 and Biophysics. His biological study spans a wide range of topics, including HEK 293 cells and Cytosol. The Endoplasmic reticulum study combines topics in areas such as Receptor, Transmembrane domain, Cysteine and Cell type.
His work carried out in the field of STIM1 brings together such families of science as Gating and Allosteric regulation. Donald L. Gill has included themes like Active site, Voltage-dependent calcium channel, Cell membrane and Calcium signaling in his Gating study. His studies deal with areas such as Mitochondrion, Programmed cell death and EF hand as well as Biophysics.
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Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels.
H T Ma;R L Patterson;D B van Rossum;L Birnbaumer.
Orai1 and STIM reconstitute store-operated calcium channel function.
Jonathan Soboloff;Maria A. Spassova;Xiang D. Tang;Thamara Hewavitharana.
Journal of Biological Chemistry (2006)
CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel
Monika Vig;Andreas Beck;James M. Billingsley;Annette Lis.
Current Biology (2006)
STIM proteins: dynamic calcium signal transducers
Jonathan Soboloff;Brad S. Rothberg;Muniswamy Madesh;Donald L. Gill.
Nature Reviews Molecular Cell Biology (2012)
Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx EVIDENCE FOR SIMILARITIES IN STORE-OPERATED AND CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL COMPONENTS
Hwei Ling Ong;Kwong Tai Cheng;Xibao Liu;Bidhan C. Bandyopadhyay.
Journal of Biological Chemistry (2007)
Store-operated Ca2+ entry: evidence for a secretion-like coupling model.
Randen L Patterson;Damian B van Rossum;Donald L Gill.
Competitive, reversible, and potent antagonism of inositol 1,4,5-trisphosphate-activated calcium release by heparin
Tarun K. Ghosh;Peggy S. Eis;Julienne M. Mullaney;Cynthia L. Ebert.
Journal of Biological Chemistry (1988)
The cellular and molecular basis of store-operated calcium entry
Kartik Venkatachalam;Damian B. van Rossum;Randen L. Patterson;Hong Tao Ma.
Nature Cell Biology (2002)
Intracellular calcium release mediated by sphingosine derivatives generated in cells.
Tarun K. Ghosh;Junhui Bian;Donald L. Gill.
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
Maria A. Spassova;Thamara Hewavitharana;Wen Xu;Jonathan Soboloff.
Proceedings of the National Academy of Sciences of the United States of America (2006)
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