World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
39680
World Ranking
4672
National Ranking
2263

Overview

Muniswamy Madesh is affiliated with The University of Texas at Austin in the United States. Their research spans multiple aspects of biochemistry, genetics, and molecular biology, with a focus on physiology and specialized subfields such as nutrition and dietetics, epidemiology, and cancer research.

The scientist's work is prominently situated in the study of mitochondrial function and pathology, with a particular emphasis on ATP synthase and ATPases, magnesium's role in health and disease, ion channel regulation and function, adipose tissue and metabolism, nitric oxide and endothelin effects, and calcium signaling alongside nucleotide metabolism.

Recent publications illustrate the breadth of their investigation. These include the following papers:

  • Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism (2020, Cell)
  • Molecular nature and physiological role of the mitochondrial calcium uniporter channel (2020, American Journal of Physiology-Cell Physiology)
  • An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter (2020, Proceedings of the National Academy of Sciences)
  • SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics (2022, iScience)
  • Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy (2020, Cell Death and Disease)

Madesh has collaborated frequently with several researchers, including Manigandan Venkatesan, R. Karthik, Soumya Maity, Peter B. Stathopulos, and Neelanjan Vishnu. These collaborations have helped to develop insights across mitochondrial biology and related physiological processes.

The primary publication venues for Madesh's work include bioRxiv (Cold Spring Harbor Laboratory), the Journal of the American Society of Nephrology, iScience, Cell Death and Disease, and Cell Calcium. This reflects an engagement with both preprint platforms and peer-reviewed journals relevant to molecular and cellular biology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

    Karthik Mallilankaraman;Patrick Doonan;César Cárdenas;César Cárdenas;Harish C. Chandramoorthy

  • STIM proteins: dynamic calcium signal transducers

    Jonathan Soboloff;Brad S. Rothberg;Muniswamy Madesh;Donald L. Gill

  • Microtiter plate assay for superoxide dismutase using MTT reduction by superoxide.

    M Madesh;K A Balasubramanian

  • Calcium signaling and apoptosis.

    György Hajnóczky;Erika Davies;Muniswamy Madesh

  • VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release

    Muniswamy Madesh;György Hajnóczky

  • MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

    Karthik Mallilankaraman;César Cárdenas;Patrick J. Doonan;Harish C. Chandramoorthy

  • The endoplasmic reticulum gateway to apoptosis by Bcl-XL modulation of the InsP3R

    Carl White;Chi Li;Jun Yang;Nataliya B. Petrenko

  • Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy.

    Partha Mukhopadhyay;Mohanraj Rajesh;György Haskó;Brian J Hawkins

  • The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

    Timothy S. Luongo;Jonathan P. Lambert;Ancai Yuan;Xueqian Zhang

  • The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.

    Timothy S. Luongo;Jonathan P. Lambert;Polina Gross;Mary Nwokedi

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Apoptosis in the intestinal epithelium: Its relevance in normal and pathophysiological conditions

    Anup Ramachandran;Muniswamy Madesh;Kunissery A Balasubramanian

  • S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

    Brian J. Hawkins;Krishna M. Irrinki;Karthik Mallilankaraman;Yu Chin Lien

  • The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria.

    György Hajnóczky;György Csordás;Muniswamy Madesh;Pál Pacher

  • The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors.

    Huafeng Wei;Ge Liang;Hui Yang;Qiujun Wang

  • Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.

    Muniswamy Madesh;Bruno Antonsson;Srinivasa M. Srinivasula;Emad S. Alnemri

  • Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.

    Rajesh Kumar Gandhirajan;Shu Meng;Harish C. Chandramoorthy;Karthik Mallilankaraman

Frequent Co-Authors

Joseph Y. Cheung
Joseph Y. Cheung Temple University
Erhe Gao
Erhe Gao Temple University
György Hajnóczky
György Hajnóczky Thomas Jefferson University
Walter J. Koch
Walter J. Koch Temple University
Steven R. Houser
Steven R. Houser Temple University
John W. Elrod
John W. Elrod Temple University
Donald L. Gill
Donald L. Gill Pennsylvania State University
Aron B. Fisher
Aron B. Fisher University of Pennsylvania
J. Kevin Foskett
J. Kevin Foskett University of Pennsylvania
Barbara A. Miller
Barbara A. Miller Pennsylvania State University

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