World's Best Scientists 2026 revealed!
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James W. Simpkins

D-Index & Metrics

Medicine

D-Index
96
Citations
29766
World Ranking
9776
National Ranking
5026

Neuroscience

D-Index
96
Citations
29570
World Ranking
880
National Ranking
472

James W. Simpkins publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where James W. Simpkins sits on this spectrum.

38–47 publications: 18 scientists 48–57 publications: 79 scientists 58–67 publications: 193 scientists 68–77 publications: 323 scientists 78–87 publications: 406 scientists 88–97 publications: 452 scientists 98–107 publications: 539 scientists 108–117 publications: 505 scientists 118–127 publications: 522 scientists 128–137 publications: 469 scientists 138–147 publications: 456 scientists 148–157 publications: 459 scientists 158–167 publications: 397 scientists 168–177 publications: 383 scientists 178–187 publications: 350 scientists 188–197 publications: 302 scientists 198–207 publications: 306 scientists 208–217 publications: 262 scientists 218–227 publications: 242 scientists 228–237 publications: 220 scientists 238–247 publications: 203 scientists 248–257 publications: 174 scientists 258–267 publications: 176 scientists 268–277 publications: 175 scientists 278–287 publications: 125 scientists 288–297 publications: 116 scientists 298–307 publications: 127 scientists 308–317 publications: 128 scientists 318–327 publications: 99 scientists 328–337 publications: 89 scientists 338–347 publications: 78 scientists 348–357 publications: 96 scientists 358–367 publications: 66 scientists 368–377 publications: 59 scientists 378–387 publications: 65 scientists 388–397 publications: 54 scientists 398–407 publications: 48 scientists 408–417 publications: 49 scientists 418–427 publications: 34 scientists 428–437 publications: 31 scientists 438–447 publications: 30 scientists 448–457 publications: 31 scientists 458–467 publications: 36 scientists 468–477 publications: 40 scientists 478–487 publications: 35 scientists 488–497 publications: 30 scientists 498–507 publications: 23 scientists 508–517 publications: 26 scientists 518–527 publications: 20 scientists 528–537 publications: 23 scientists 538–547 publications: 20 scientists 548–557 publications: 20 scientists 558–567 publications: 17 scientists 568–577 publications: 14 scientists 578–587 publications: 20 scientists 588–597 publications: 20 scientists 598–607 publications: 19 scientists 608–617 publications: 18 scientists 618–627 publications: 17 scientists 628–637 publications: 11 scientists 638–647 publications: 11 scientists 648–657 publications: 11 scientists 658–667 publications: 8 scientists 668–677 publications: 7 scientists 678–687 publications: 11 scientists 688–697 publications: 10 scientists 698–707 publications: 4 scientists 708–717 publications: 6 scientists 718–727 publications: 5 scientists 728–737 publications: 5 scientists 738–747 publications: 9 scientists 748–757 publications: 9 scientists 758–767 publications: 3 scientists 768–777 publications: 7 scientists 778–787 publications: 7 scientists 788–797 publications: 6 scientists 798–807 publications: 2 scientists 808–817 publications: 2 scientists 818–827 publications: 7 scientists 828–837 publications: 0 scientists 838–847 publications: 9 scientists 848–857 publications: 3 scientists 858–867 publications: 1 scientists 868–877 publications: 3 scientists 878–886 publications: 6 scientists 887+ publications: 100 scientists
38 publications 887+

This scientist: 460 publications — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 887 publications or more.

James W. Simpkins D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where James W. Simpkins sits on this spectrum.

30–31 D-Index: 42 scientists 32–33 D-Index: 172 scientists 34–35 D-Index: 296 scientists 36–37 D-Index: 435 scientists 38–39 D-Index: 459 scientists 40–41 D-Index: 456 scientists 42–43 D-Index: 467 scientists 44–45 D-Index: 478 scientists 46–47 D-Index: 512 scientists 48–49 D-Index: 435 scientists 50–51 D-Index: 425 scientists 52–53 D-Index: 418 scientists 54–55 D-Index: 392 scientists 56–57 D-Index: 357 scientists 58–59 D-Index: 334 scientists 60–61 D-Index: 328 scientists 62–63 D-Index: 260 scientists 64–65 D-Index: 278 scientists 66–67 D-Index: 239 scientists 68–69 D-Index: 250 scientists 70–71 D-Index: 210 scientists 72–73 D-Index: 200 scientists 74–75 D-Index: 189 scientists 76–77 D-Index: 170 scientists 78–79 D-Index: 146 scientists 80–81 D-Index: 113 scientists 82–83 D-Index: 126 scientists 84–85 D-Index: 100 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 99 scientists 90–91 D-Index: 84 scientists 92–93 D-Index: 85 scientists 94–95 D-Index: 72 scientists 96–97 D-Index: 76 scientists 98–99 D-Index: 45 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 43 scientists 104–105 D-Index: 32 scientists 106–107 D-Index: 45 scientists 108–109 D-Index: 50 scientists 110–111 D-Index: 32 scientists 112–113 D-Index: 39 scientists 114–115 D-Index: 32 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 27 scientists 120–121 D-Index: 19 scientists 122–123 D-Index: 23 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 16 scientists 128–129 D-Index: 24 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 21 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 14 scientists 138–139 D-Index: 15 scientists 140–141 D-Index: 10 scientists 142–143 D-Index: 10 scientists 144–145 D-Index: 13 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 8 scientists 150–151 D-Index: 6 scientists 152–153 D-Index: 6 scientists 154–155 D-Index: 7 scientists 156–157 D-Index: 7 scientists 158–159 D-Index: 10 scientists 160–161 D-Index: 4 scientists 162 D-Index: 8 scientists 163+ D-Index: 100 scientists
30 D-Index 163+

This scientist: 96 D-Index — 91st percentile

91% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 163 D-Index or more.

Overview

James W. Simpkins is affiliated with West Virginia University in the United States. Their research contributions span multiple disciplines, primarily within biochemistry, genetics, molecular biology, neuroscience, and medicine. Subfields of focus include molecular biology, neurology, physiology, cancer research, and genetics.

Their work engages with several key topics, notably:

  • Extracellular vesicles in disease
  • Alzheimer's disease research and treatments
  • Neuroinflammation and neurodegeneration mechanisms
  • Barrier structure and function studies
  • Neurological disease mechanisms and treatments
  • MicroRNA in disease regulation
  • RNA interference and gene delivery

Simpkins has published extensively in journals such as Biosensors and Bioelectronics, Nature Communications, Journal of Alzheimer's Disease, Alzheimer's & Dementia, and Metabolic Brain Disease.

Recent papers authored or co-authored by Simpkins include:

  • "Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke" (2020) published in Metabolic Brain Disease
  • "A 'hot Spot'-Enhanced paper lateral flow assay for ultrasensitive detection of traumatic brain injury biomarker S-100β in blood plasma" (2021) published in Biosensors and Bioelectronics
  • "Blood substitution therapy rescues the brain of mice from ischemic damage" (2020) published in Nature Communications
  • "Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells" (2020) published in Journal of Alzheimer's Disease
  • "miR-146a Dysregulates Energy Metabolism During Neuroinflammation" (2021) published in Journal of Neuroimmune Pharmacology

Among frequent collaborators, Simpkins has worked with Saumyendra N. Sarkar, Xuefang Ren, Elizabeth B. Engler-Chiurazzi, Heng Hu, and Dominic D. Quintana multiple times, reflecting ongoing partnerships in research projects.

Best Publications

  • Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.

    Meharvan Singh;Edwin M. Meyer;William J. Millard;James W. Simpkins

  • Neuroprotective effects of estrogens: potential mechanisms of action.

    Pattie S. Green;James W. Simpkins

  • Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.

    James W. Simpkins;Gopal Rajakumar;Yu Qi Zhang;Christopher E. Simpkins

  • The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

    Meharvan Singh;E. M. Meyer;J. W. Simpkins

  • Mitochondrial localization of estrogen receptor β

    Shao Hua Yang;Ran Liu;Evelyn J. Perez;Yi Wen

  • Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

    David E. Harrison;Randy Strong;David B. Allison;Bruce N. Ames

  • Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

    Giuseppina Tesco;Young Ho Koh;Eugene L. Kang;Andrew N. Cameron

  • Role of Estrogen Replacement Therapy in Memory Enhancement and the Prevention of Neuronal Loss Associated With Alzheimer’s Disease

    James W Simpkins;Pattie S Green;Kelly E Gridley;Meharvan Singh

  • Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

    Randy Strong;Richard A Miller;Adam Antebi;Clinton M Astle

  • Evidence for Depressed Catecholamine and Enhanced Serotonin Metabolism in Aging Male Rats: Possible Relation to Gondotropin Secretion2

    J. W. Simpkins;G. P. Mueller;H. H. Huang;J. Meites

  • 17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

    Pattie S. Green;Jean Bishop;James W. Simpkins

  • Effects of gender and estradiol treatment on focal brain ischemia

    Yu Qi Zhang;Jiong Shi;Gopal Rajakumar;Arthur L. Day

  • Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro.

    Adam M. Persky;Pattie S. Green;Leighann Stubley;Cynthia O. Howell

  • Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

    Pattie S. Green;Kelly E. Gridley;James W. Simpkins

  • Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells

    J. Wang;P. S. Green;J. W. Simpkins

  • Estradiol Exerts Neuroprotective Effects When Administered After Ischemic Insult

    Shao Hua Yang;Jiong Shi;Arthur L Day;James W. Simpkins

  • Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

    Yi Wen;Wenjun Li;Ethan C. Poteet;Luokun Xie

  • Increased β-secretase activity and expression in rats following transient cerebral ischemia

    Yi Wen;Otuonye Onyewuchi;Shaohua Yang;Ran Liu

  • The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population

    Kunlin Jin;James W. Simpkins;Xunming Ji;Miriam Leis

  • Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats

    Toni Hawk;Y. Q. Zhang;Gopal Rajakumar;Arthur L. Day

  • Phenolic A ring requirement for the neuroprotective effects of steroids

    Pattie S. Green;Katherine Gordon;James W. Simpkins

Frequent Co-Authors

Nicholas Bodor
Nicholas Bodor University of Florida
Satya P. Kalra
Satya P. Kalra University of Florida
Douglas F. Covey
Douglas F. Covey Washington University in St. Louis
Pushpa S. Kalra
Pushpa S. Kalra University of Florida
Marcus E. Brewster
Marcus E. Brewster Johnson & Johnson (United States)
Joseph Meites
Joseph Meites Michigan State University
Ahamed H. Idris
Ahamed H. Idris The University of Texas Southwestern Medical Center
Liang-Jun Yan
Liang-Jun Yan University of North Texas Health Science Center
Edwin M. Meyer
Edwin M. Meyer University of Florida
Robert J. Handa
Robert J. Handa Colorado State University

External Links

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Related Online Degrees & Career Pathways

Exploring a degree in neuroscience can open doors to numerous rewarding careers. For students who care about potential earnings, you may want to consider the most profitable degrees related to neuroscience, such as biomedical engineering, psychology, or computer science. These fields can offer strong salaries and long-term job security.

Many students seek flexible learning options. If you want to pursue your education remotely while keeping costs down, it’s wise to look for an online college that accepts fafsa. Enrolling in accredited programs can make you eligible for federal financial aid.

To boost your employability, you can supplement your neuroscience studies with online certifications. Specialized certifications in data analysis, clinical research, or health informatics can lead to well-paying positions.

If you prefer a quicker route to graduation, you might consider the easiest online bachelor degree options, which may include related fields such as psychology or health sciences. These pathways can provide valuable skills and open a wide array of career opportunities.

Best Scientists Citing James W. Simpkins

Luis M. Garcia-Segura

Luis M. Garcia-Segura

Spanish National Research Council

Publications: 102

Phyllis M. Wise

Phyllis M. Wise

University of Washington

Publications: 66

Roberta Diaz Brinton

Roberta Diaz Brinton

University of Arizona

Publications: 61

Nicholas Bodor

Nicholas Bodor

University of Florida

Publications: 57

Farida Sohrabji

Farida Sohrabji

Texas A&M University

Publications: 41

Satya P. Kalra

Satya P. Kalra

University of Florida

Publications: 39

Bruce S. McEwen

Bruce S. McEwen

Rockefeller University

Publications: 39

Christian J. Pike

Christian J. Pike

University of Southern California

Publications: 38

Richard A. Miller

Richard A. Miller

University of Michigan–Ann Arbor

Publications: 38

George E. Barreto

George E. Barreto

University of Limerick

Publications: 35

Darrell W. Brann

Darrell W. Brann

Augusta University

Publications: 35

Caleb E. Finch

Caleb E. Finch

University of Southern California

Publications: 31

Philip W. Landfield

Philip W. Landfield

University of Kentucky

Publications: 30

William R. Crowley

William R. Crowley

University of Utah

Publications: 29

George Perry

George Perry

The University of Texas at San Antonio

Publications: 29

Louise D. McCullough

Louise D. McCullough

The University of Texas Health Science Center at Houston

Publications: 28

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