World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
96
Citations
29570
World Ranking
880
National Ranking
472

Medicine

D-Index
96
Citations
29766
World Ranking
9776
National Ranking
5026

Overview

James W. Simpkins is affiliated with West Virginia University in the United States. Their research contributions span multiple disciplines, primarily within biochemistry, genetics, molecular biology, neuroscience, and medicine. Subfields of focus include molecular biology, neurology, physiology, cancer research, and genetics.

Their work engages with several key topics, notably:

  • Extracellular vesicles in disease
  • Alzheimer's disease research and treatments
  • Neuroinflammation and neurodegeneration mechanisms
  • Barrier structure and function studies
  • Neurological disease mechanisms and treatments
  • MicroRNA in disease regulation
  • RNA interference and gene delivery

Simpkins has published extensively in journals such as Biosensors and Bioelectronics, Nature Communications, Journal of Alzheimer's Disease, Alzheimer's & Dementia, and Metabolic Brain Disease.

Recent papers authored or co-authored by Simpkins include:

  • "Mechanisms in blood-brain barrier opening and metabolism-challenged cerebrovascular ischemia with emphasis on ischemic stroke" (2020) published in Metabolic Brain Disease
  • "A 'hot Spot'-Enhanced paper lateral flow assay for ultrasensitive detection of traumatic brain injury biomarker S-100β in blood plasma" (2021) published in Biosensors and Bioelectronics
  • "Blood substitution therapy rescues the brain of mice from ischemic damage" (2020) published in Nature Communications
  • "Amyloid-β Causes Mitochondrial Dysfunction via a Ca2+-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells" (2020) published in Journal of Alzheimer's Disease
  • "miR-146a Dysregulates Energy Metabolism During Neuroinflammation" (2021) published in Journal of Neuroimmune Pharmacology

Among frequent collaborators, Simpkins has worked with Saumyendra N. Sarkar, Xuefang Ren, Elizabeth B. Engler-Chiurazzi, Heng Hu, and Dominic D. Quintana multiple times, reflecting ongoing partnerships in research projects.

Best Publications

  • Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats.

    Meharvan Singh;Edwin M. Meyer;William J. Millard;James W. Simpkins

  • Neuroprotective effects of estrogens: potential mechanisms of action.

    Pattie S. Green;James W. Simpkins

  • Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat.

    James W. Simpkins;Gopal Rajakumar;Yu Qi Zhang;Christopher E. Simpkins

  • The effect of ovariectomy and estradiol replacement on brain-derived neurotrophic factor messenger ribonucleic acid expression in cortical and hippocampal brain regions of female Sprague-Dawley rats.

    Meharvan Singh;E. M. Meyer;J. W. Simpkins

  • Mitochondrial localization of estrogen receptor β

    Shao Hua Yang;Ran Liu;Evelyn J. Perez;Yi Wen

  • Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

    David E. Harrison;Randy Strong;David B. Allison;Bruce N. Ames

  • Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

    Giuseppina Tesco;Young Ho Koh;Eugene L. Kang;Andrew N. Cameron

  • Role of Estrogen Replacement Therapy in Memory Enhancement and the Prevention of Neuronal Loss Associated With Alzheimer’s Disease

    James W Simpkins;Pattie S Green;Kelly E Gridley;Meharvan Singh

  • Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

    Randy Strong;Richard A Miller;Adam Antebi;Clinton M Astle

  • Evidence for Depressed Catecholamine and Enhanced Serotonin Metabolism in Aging Male Rats: Possible Relation to Gondotropin Secretion2

    J. W. Simpkins;G. P. Mueller;H. H. Huang;J. Meites

  • 17α-Estradiol Exerts Neuroprotective Effects on SK-N-SH Cells

    Pattie S. Green;Jean Bishop;James W. Simpkins

  • Effects of gender and estradiol treatment on focal brain ischemia

    Yu Qi Zhang;Jiong Shi;Gopal Rajakumar;Arthur L. Day

  • Protective effect of estrogens against oxidative damage to heart and skeletal muscle in vivo and in vitro.

    Adam M. Persky;Pattie S. Green;Leighann Stubley;Cynthia O. Howell

  • Estradiol protects against β-amyloid (25–35)-induced toxicity in SK-N-SH human neuroblastoma cells

    Pattie S. Green;Kelly E. Gridley;James W. Simpkins

  • Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells

    J. Wang;P. S. Green;J. W. Simpkins

  • Estradiol Exerts Neuroprotective Effects When Administered After Ischemic Insult

    Shao Hua Yang;Jiong Shi;Arthur L Day;James W. Simpkins

  • Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection

    Yi Wen;Wenjun Li;Ethan C. Poteet;Luokun Xie

  • Increased β-secretase activity and expression in rats following transient cerebral ischemia

    Yi Wen;Otuonye Onyewuchi;Shaohua Yang;Ran Liu

  • The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population

    Kunlin Jin;James W. Simpkins;Xunming Ji;Miriam Leis

  • Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats

    Toni Hawk;Y. Q. Zhang;Gopal Rajakumar;Arthur L. Day

  • Phenolic A ring requirement for the neuroprotective effects of steroids

    Pattie S. Green;Katherine Gordon;James W. Simpkins

Frequent Co-Authors

Nicholas Bodor
Nicholas Bodor University of Florida
Satya P. Kalra
Satya P. Kalra University of Florida
Douglas F. Covey
Douglas F. Covey Washington University in St. Louis
Pushpa S. Kalra
Pushpa S. Kalra University of Florida
Marcus E. Brewster
Marcus E. Brewster Johnson & Johnson (United States)
Joseph Meites
Joseph Meites Michigan State University
Ahamed H. Idris
Ahamed H. Idris The University of Texas Southwestern Medical Center
Liang-Jun Yan
Liang-Jun Yan University of North Texas Health Science Center
Edwin M. Meyer
Edwin M. Meyer University of Florida
Robert J. Handa
Robert J. Handa Colorado State University

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