Douglas F. Covey

Overview

Best Publications

• Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex

  Brian M. Castellano;Ashley M. Thelen;Ofer Moldavski;McKenna Feltes

  474
  Citations

• The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response

  Mathieu Blanc;Wei Yuan Hsieh;Kevin A. Robertson;Kai A. Kropp

  429
  Citations

• Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action.

  Ren Qi Huang;Cathy L. Bell-Horner;Mohammed I. Dibas;Douglas F. Covey

  418
  Citations

• Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages.

  Yankun Li;Mingtao Ge;Laura Ciani;George Kuriakose

  399
  Citations

• Structural basis of Smoothened regulation by its extracellular domains

  Eamon F. X. Byrne;Ria Sircar;Paul S. Miller;George Hedger

  379
  Citations

• Sterol Intermediates from Cholesterol Biosynthetic Pathway as Liver X Receptor Ligands

  Chendong Yang;Jeffrey G. McDonald;Amit Patel;Yuan Zhang

  364
  Citations

• Gastrointestinal absorption and plasma kinetics of soy Δ5-phytosterols and phytostanols in humans

  Richard E. Ostlund;Janet B. McGill;Chun-Min Zeng;Douglas F. Covey

  334
  Citations

• Oxysterols are allosteric activators of the oncoprotein Smoothened

  Sigrid Nachtergaele;Laurel K Mydock;Kathiresan Krishnan;Jayan Rammohan

  315
  Citations

• Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis

  Thierry Bordet;Bruno Buisson;Magali Michaud;Cyrille Drouot

  311
  Citations

• Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

  Xiaochao Wei;Haowei Song;Li Yin;Michael G. Rizzo

  269
  Citations

• Anticonvulsant medications extend worm life-span.

  Kimberley Evason;Cheng Huang;Idella Yamben;Douglas F. Covey

  237
  Citations

• Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

  Giovanni Luchetti;Ria Sircar;Jennifer H Kong;Sigrid Nachtergaele

  225
  Citations

• Neurosteroids, stress and depression: Potential therapeutic opportunities

  Charles F. Zorumski;Steven M. Paul;Yukitoshi Izumi;Douglas F. Covey

  216
  Citations

• Mechanisms of neurosteroid interactions with GABAA receptors

  Gustav Akk;Douglas F. Covey;Alex S. Evers;Joe Henry Steinbach

  193
  Citations

• 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.

  Mingde Wang;Yejun He;Lawrence N. Eisenman;Christopher Fields

  190
  Citations

• Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants

  Ming Xu;D. F. Covey;M. H. Akabas

  178
  Citations

• 10 beta-propynyl-substituted steroids. Mechanism-based enzyme-activated irreversible inhibitors of estrogen biosynthesis.

  D F Covey;W F Hood;V D Parikh

  177
  Citations

• Pregnane X receptor (PXR) activation: A mechanism for neuroprotection in a mouse model of Niemann-Pick C disease

  S. Joshua Langmade;Sarah E. Gale;Andrey Frolov;Ikuko Mohri

  177
  Citations

• Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

  Sigrid Nachtergaele;Daniel M Whalen;Laurel K Mydock;Zhonghua Zhao

  177
  Citations

• Cholesterol Depletion Results in Site-specific Increases in Epidermal Growth Factor Receptor Phosphorylation due to Membrane Level Effects STUDIES WITH CHOLESTEROL ENANTIOMERS

  Emily J. Westover;Douglas F. Covey;Howard L. Brockman;Rhoderick E. Brown

  173
  Citations