Christian Siebold

Overview

Best Publications

• MHC class II proteins and disease: a structural perspective

  E Y Jones;L Fugger;L Fugger;J L Strominger;C Siebold

  522
  Citations

• Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans

  David A. Keays;Guoling Tian;Karine Poirier;Guo Jen Huang

  486
  Citations

• Structural basis of Smoothened regulation by its extracellular domains

  Eamon F. X. Byrne;Ria Sircar;Paul S. Miller;George Hedger

  379
  Citations

• Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension

  Charlotte H. Coles;Yingjie Shen;Alan P. Tenney;Alan P. Tenney;Christian Siebold

  354
  Citations

• Initiation of T cell signaling by CD45 segregation at 'close contacts'

  Veronica T Chang;Ricardo A Fernandes;Kristina A Ganzinger;Steven F Lee

  311
  Citations

• A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization.

  T.S. Walter;J.M. Diprose;C.J. Mayo;C. Siebold

  286
  Citations

• Structural basis of semaphorin–plexin signalling

  Bert J. C. Janssen;Ross A. Robinson;Francesc Pérez-Brangulí;Christian H. Bell

  273
  Citations

• Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).

  Karine Poirier;Karine Poirier;David A. Keays;Fiona Francis;Fiona Francis;Yoann Saillour;Yoann Saillour

  264
  Citations

• Interactions between Hedgehog proteins and their binding partners come into view.

  Philip A. Beachy;Sarah G. Hymowitz;Robert A. Lazarus;Daniel J. Leahy

  254
  Citations

• Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

  Giovanni Luchetti;Ria Sircar;Jennifer H Kong;Sigrid Nachtergaele

  225
  Citations

• Biochemical mechanisms of vertebrate hedgehog signaling.

  Jennifer H. Kong;Christian Siebold;Rajat Rohatgi

  209
  Citations

• Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

  Janssen Bjc.;T Malinauskas;G A Weir;M Z Cader

  208
  Citations

• Structure of the Fungal Beta-Glucan-Binding Immune Receptor Dectin-1: Implications for Function.

  J. Brown;C.A. O'Callaghan;A.S.J. Marshall;R.J.C. Gilbert

  198
  Citations

• Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy

  Christian Siebold;Bjarke E. Hansen;Jessica R. Wyer;Karl Harlos

  185
  Citations

• Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.

  M Lu;H Breyssens;V Salter;S Zhong

  183
  Citations

• Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

  Sigrid Nachtergaele;Daniel M Whalen;Laurel K Mydock;Zhonghua Zhao

  177
  Citations

• Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

  T Malinauskas;A R Aricescu;W Lu;C Siebold

  174
  Citations

• Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

  J Elegheert;E Behiels;E Behiels;E Behiels;B Bishop;S Scott;S Scott

  168
  Citations

• Carbohydrate transporters of the bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS)

  Christian Siebold;Karin Flükiger;Rudolf Beutler;Bernhard Erni

  153
  Citations

• Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

  B Bishop;A R Aricescu;K Harlos;C A O'Callaghan

  147
  Citations