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R. Jeroen Pasterkamp

R. Jeroen Pasterkamp

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
18407
World Ranking
5956
National Ranking
151

Overview

R. Jeroen Pasterkamp is affiliated with Utrecht University in the Netherlands. Their research spans several interconnected domains within the life sciences, particularly focusing on the molecular and cellular mechanisms underpinning neurological conditions and genetic regulation.

The scientist's recent publications highlight a focus on neuroscience and molecular biology. Selected papers include:

  • Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain, 2021, published in Neuron
  • Best practice standards for circular RNA research, 2022, published in Nature Methods
  • Development, wiring and function of dopamine neuron subtypes, 2023, published in Nature Reviews Neuroscience
  • Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain, 2021, published in Journal of Neuroscience
  • Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS, 2022, published in Science Translational Medicine

Their frequent co-authors include:

  • Youri Adolfs
  • Jan H. Veldink
  • Elly M. Hol
  • Jørgen Kjems
  • Pavol Zelina

The primary publication venues for their work have been:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Neuron
  • Journal of Neuroscience

Pasterkamp's research areas encompass several main fields of study, which include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience
  • Medicine

Within these fields, subfields of particular focus are:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Neurology
  • Cell Biology
  • Developmental Neuroscience

Their work addresses various main topics such as:

  • Amyotrophic Lateral Sclerosis Research
  • Axon Guidance and Neuronal Signaling
  • Neurogenesis and neuroplasticity mechanisms
  • MicroRNA in disease regulation
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Pluripotent Stem Cells Research
  • RNA Research and Splicing

This profile reveals a consistent engagement with both experimental and analytical approaches in understanding cellular communication and regulation, particularly in neurological contexts and disease mechanisms. The combination of topics and venues further reflects an interdisciplinary approach bridging molecular biology and neuroscience.

Best Publications

  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

    Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  • Protein aggregation in amyotrophic lateral sclerosis

    Anna M. Blokhuis;Ewout J. N. Groen;Max Koppers;Leonard H. van den Berg

  • Semaphorin 7A promotes axon outgrowth through integrins and MAPKs

    R. Jeroen Pasterkamp;Jacques J. Peschon;Melanie K. Spriggs;Alex L. Kolodkin

  • Microglia innately develop within cerebral organoids.

    Paul R. Ormel;Renata Vieira de Sá;Emma J. van Bodegraven;Henk Karst

  • Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

    Yingxiao Shi;Shaoyu Lin;Kim A. Staats;Yichen Li

  • Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.

    Michael A van Es;Jan H Veldink;Christiaan G J Saris;Hylke M Blauw

  • MICALs, a Family of Conserved Flavoprotein Oxidoreductases, Function in Plexin-Mediated Axonal Repulsion

    Jonathan R. Terman;Tianyi Mao;R. Jeroen Pasterkamp;Hung Hsiang Yu;Hung Hsiang Yu

  • Semaphorin junction: making tracks toward neural connectivity.

    R Jeroen Pasterkamp;Alex L Kolodkin

  • Semaphorin signaling: progress made and promises ahead.

    Yeping Zhou;Rou-Afza F. Gunput;R. Jeroen Pasterkamp

  • Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin

    Kazuhiro Suzuki;Tatsusada Okuno;Midori Yamamoto;R. Jeroen Pasterkamp

  • Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.

    R.J. Pasterkamp;R.J. Giger;M.J. Ruitenberg;A.J.G.D. Holtmaat

  • Getting neural circuits into shape with semaphorins

    R. Jeroen Pasterkamp

  • C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

    Max Koppers;Anna M. Blokhuis;Henk Jan Westeneng;Margo L. Terpstra

  • Semaphorin function in neural plasticity and disease

    R Jeroen Pasterkamp;Roman J Giger

  • MicroRNAs in epilepsy: pathophysiology and clinical utility

    David C Henshall;Hajo M Hamer;R Jeroen Pasterkamp;David B Goldstein

  • Axon guidance proteins in neurological disorders

    Eljo Y Van Battum;Sara Brignani;R Jeroen Pasterkamp

  • Evidence for a Role of the Chemorepellent Semaphorin III and Its Receptor Neuropilin-1 in the Regeneration of Primary Olfactory Axons

    R. Jeroen Pasterkamp;Fred De Winter;Anthony J. G. D. Holtmaat;Joost Verhaagen

  • Semaphorin signalling during development.

    Bart C. Jongbloets;R. Jeroen Pasterkamp

  • Getting connected in the dopamine system.

    Dianne M.A. Van den Heuvel;R. Jeroen Pasterkamp

  • Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

    Wouter van Rheenen;Rick A. A. van der Spek;Mark K. Bakker;Joke J. F. A. van Vugt

Frequent Co-Authors

Leonard H. van den Berg
Leonard H. van den Berg Utrecht University
Jan H. Veldink
Jan H. Veldink Utrecht University
Casper C. Hoogenraad
Casper C. Hoogenraad Utrecht University
Alex L. Kolodkin
Alex L. Kolodkin Johns Hopkins University School of Medicine
Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
Felix Rosenow
Felix Rosenow Goethe University Frankfurt
Anna Akhmanova
Anna Akhmanova Utrecht University
Roel A. Ophoff
Roel A. Ophoff University of California, Los Angeles

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