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Chemistry

D-Index
47
Citations
7957
World Ranking
15644
National Ranking
3939

Overview

Hugh O'Neill is affiliated with Oak Ridge National Laboratory in the United States and has an extensive research portfolio primarily situated in Biochemistry, Genetics and Molecular Biology. Their research embraces subfields such as Molecular Biology, Biomedical Engineering, Biomaterials, Materials Chemistry, and Plant Science.

The scientist has contributed notably to topics including Advanced Cellulose Research Studies, Enzyme Structure and Function, Protein Structure and Dynamics, Lignin and Wood Chemistry, Biofuel production and bioconversion, Polysaccharides and Plant Cell Walls, and Nuclear Physics and Applications.

Frequent publication venues for Hugh O'Neill include:

  • Acta Crystallographica Section A Foundations and Advances
  • ACS Sustainable Chemistry & Engineering
  • Journal of Biological Chemistry
  • Goldschmidt Abstracts
  • Nature Communications

Notable recent papers authored or co-authored include:

  • Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography, 2020, Nature Communications
  • Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical Antivirals, 2020, Structure
  • Unusual zwitterionic catalytic site of SARS-CoV-2 main protease revealed by neutron crystallography, 2020, Journal of Biological Chemistry
  • Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2, 2023, Nature Communications
  • Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL Mpro: insights into enzyme mechanism and drug design, 2020, IUCrJ

Hugh O'Neill has collaborated frequently with the following researchers:

  • Sai Venkatesh Pingali
  • Volker S. Urban
  • Wellington Leite
  • Kevin L. Weiss
  • Brian H. Davison

Best Publications

  • Structural plasticity of SARS-CoV-2 3CL M pro active site cavity revealed by room temperature X-ray crystallography.

    Daniel W. Kneller;Gwyndalyn Phillips;Hugh M. O’Neill;Robert Jedrzejczak

  • Biomimetic synthesis of calcium-deficient hydroxyapatite in a natural hydrogel.

    Stacy A Hutchens;Roberto S. Benson;Barbara R Evans;Hugh Michael O'Neill

  • Palladium-bacterial cellulose membranes for fuel cells.

    Barbara R. Evans;Hugh M. O'Neill;Valerie P. Malyvanh;Ida Lee

  • Common processes drive the thermochemical pretreatment of lignocellulosic biomass

    Paul Langan;Paul Langan;Loukas Petridis;Loukas Petridis;Hugh M. O'Neill;Sai Venkatesh Pingali

  • High photo-electrochemical activity of thylakoid–carbon nanotube composites for photosynthetic energy conversion

    Jessica O. Calkins;Yogeswaran Umasankar;Hugh O'Neill;Ramaraja P. Ramasamy

  • Self-organized photosynthetic nanoparticle for cell-free hydrogen production

    Ifeyinwa J Iwuchukwu;Michael D Vaughn;Natalie Myers;Hugh Michael O'Neill;Hugh Michael O'Neill

  • Breakdown of cell wall nanostructure in dilute acid pretreated biomass.

    Sai Venkatesh Pingali;Volker S Urban;William T Heller;Joseph McGaughey

  • Mechanical formation of micro- and nano-plastic materials for environmental studies in agricultural ecosystems.

    A.F. Astner;D.G. Hayes;H. O'Neill;B.R. Evans

  • Effect of lignin content on changes occurring in poplar cellulose ultrastructure during dilute acid pretreatment

    Qining Sun;Marcus Foston;Xianzhi Meng;Daisuke Sawada

  • Dynamics of Protein and its Hydration Water: Neutron Scattering Studies on Fully Deuterated GFP

    Jonathan D. Nickels;Hugh O’Neill;Hugh O’Neill;Liang Hong;Liang Hong;Madhusudan Tyagi;Madhusudan Tyagi

  • A microbial fuel cell operating at low pH using the acidophile Acidiphilium cryptum.

    Abhijeet P. Borole;Hugh O’Neill;Costas Tsouris;Scott Cesar

  • The Shape of Native Plant Cellulose Microfibrils

    James D. Kubicki;Hui Yang;Daisuke Sawada;Hugh O’Neill

  • Dynamics of water bound to crystalline cellulose

    Hugh O'Neill;Hugh O'Neill;Sai Venkatesh Pingali;Loukas Petridis;Loukas Petridis;Junhong He

  • The Bio‐SANS instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory

    William T. Heller;Volker S. Urban;Gary W. Lynn;Kevin L. Weiss

  • Organization and Flexibility of Cyanobacterial Thylakoid Membranes Examined by Neutron Scattering

    Michelle Liberton;Lawrence E. Page;William B. O'Dell;Hugh O'Neill

  • A Structural Study of CESA1 Catalytic Domain of Arabidopsis Cellulose Synthesis Complex: Evidence for CESA Trimers

    Venu Gopal Vandavasi;Daniel K. Putnam;Qiu Zhang;Loukas Petridis

  • Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical Antivirals

    Daniel W. Kneller;Stephanie Galanie;Gwyndalyn Phillips;Gwyndalyn Phillips;Hugh M. O'Neill;Hugh M. O'Neill

  • Unusual zwitterionic catalytic site of SARS-CoV-2 main protease revealed by neutron crystallography.

    Daniel W. Kneller;Daniel W. Kneller;Gwyndalyn Phillips;Gwyndalyn Phillips;Kevin L. Weiss;Kevin L. Weiss;Swati Pant;Swati Pant

  • Generation of the configurational ensemble of an intrinsically disordered protein from unbiased molecular dynamics simulation.

    Utsab R. Shrestha;Puneet Juneja;Qiu Zhang;Viswanathan Gurumoorthy

  • Modification of the nanostructure of lignocellulose cell walls via a non-enzymatic lignocellulose deconstruction system in brown rot wood-decay fungi

    Barry Goodell;Yuan Zhu;Seong Kim;Kabindra Kafle

  • Characterization of the Influence of the Ionic Liquid 1-Butyl-3-methylimidazolium Chloride on the Structure and Thermal Stability of Green Fluorescent Protein

    William T Heller;Hugh Michael O'Neill;Qiu Zhang;Gary A Baker

Frequent Co-Authors

Eugene Mamontov
Eugene Mamontov Oak Ridge National Laboratory
Arthur J. Ragauskas
Arthur J. Ragauskas University of Tennessee at Knoxville
Jeremy C. Smith
Jeremy C. Smith University of Tennessee at Knoxville
Paul Langan
Paul Langan Oak Ridge National Laboratory
Alexei P. Sokolov
Alexei P. Sokolov University of Tennessee at Knoxville
Brian H. Davison
Brian H. Davison Oak Ridge National Laboratory
Gary A. Baker
Gary A. Baker University of Missouri
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Andrey Kovalevsky
Andrey Kovalevsky Oak Ridge National Laboratory
Kunlun Hong
Kunlun Hong Oak Ridge National Laboratory

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