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Robert J. C. Gilbert

Robert J. C. Gilbert

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
14269
World Ranking
10222
National Ranking
779

Overview

Robert J. C. Gilbert is affiliated with the University of Oxford in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with specific focus on Molecular Biology, Immunology, Public Health, Environmental and Occupational Health, Atomic and Molecular Physics, and Infectious Diseases.

The scientist has contributed to various topics, including:

  • Lipid Membrane Structure and Behavior
  • Force Microscopy Techniques and Applications
  • Streptococcal Infections and Treatments
  • RNA and protein synthesis mechanisms
  • Clostridium difficile and Clostridium perfringens research
  • Toxin Mechanisms and Immunotoxins
  • Advanced Electron Microscopy Techniques and Applications

Their recent publications include the following papers:

  • "Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity" (2020) published in Science Advances
  • "Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling" (2021) published in Nature Communications
  • "Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism" (2022) published in Nature Communications
  • "Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation" (2022) published in The EMBO Journal
  • "Electron microscopy as a critical tool in the determination of pore forming mechanisms in proteins" (2021) published in Methods in enzymology on CD-ROM/Methods in enzymology

The scientist frequently collaborates with other researchers, including Tao Ni, Peijun Zhang, Xiulian Yu, Gangshun Yi, and Mingda Ye.

Their work has been published extensively across several venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • European Biophysics Journal
  • Frontiers in Immunology
  • Science Advances

Best Publications

  • Processing of tumour necrosis factor-alpha precursor by metalloproteinases

    A. J. H. Gearing;P. Beckett;M. Christodoulou;M. Churchill

  • The interaction properties of costimulatory molecules revisited.

    Alison V. Collins;Douglas W. Brodie;Robert J.C. Gilbert;Andrea Iaboni

  • The long and short of microRNA.

    Luke A. Yates;Chris J. Norbury;Robert J.C. Gilbert

  • Structural Basis of Pore Formation by the Bacterial Toxin Pneumolysin

    Sarah J. Tilley;Elena V. Orlova;Robert J.C. Gilbert;Robert J.C. Gilbert;Peter W. Andrew

  • A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting

    Olivier Namy;Stephen J. Moran;David I. Stuart;Robert J. C. Gilbert

  • Matrix metalloproteinases and processing of pro-TNF-alpha.

    A J Gearing;P Beckett;M Christodoulou;M Churchill

  • Initiation of T cell signaling by CD45 segregation at 'close contacts'

    Veronica T Chang;Ricardo A Fernandes;Kristina A Ganzinger;Steven F Lee

  • Transgenic potato plants with enhanced resistance to the tomato moth, Lacanobia oleracea: growth room trials

    Angharad M.R. Gatehouse;Gillian M. Davison;Christine A. Newell;Andrew Merryweather

  • Structure and dimerization of a soluble form of B7-1.

    S Ikemizu;R J Gilbert;R J Gilbert;J A Fennelly;A V Collins

  • The Nsp9 Replicase Protein of Sars-Coronavirus, Structure and Functional Insights

    Geoff Sutton;Elizabeth Fry;Lester Carter;Sarah Sainsbury

  • Pore-forming toxins.

    R J C Gilbert

  • Viral RNA pseudoknots: versatile motifs in gene expression and replication.

    Ian Brierley;Simon Pennell;Robert J C Gilbert

  • Structural basis of Nipah and Hendra virus attachment to their cell-surface receptor ephrin-B2

    T.A Bowden;A.R Aricescu;R.J Gilbert;J.M Grimes

  • Crystal structure of a soluble CD28-Fab complex

    E J Evans;R M Esnouf;R Manso-Sancho;Gilbert Rjc.

  • Human erythrocytes bind and inactivate type 5 adenovirus by presenting Coxsackie virus-adenovirus receptor and complement receptor 1

    Robert C. Carlisle;Ying Di;Anna M. Cerny;Andreas F.-P. Sonnen

  • Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae.

    Robert J.C Gilbert;Jose L Jiménez;Shaoxia Chen;Ian J Tickle

  • Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.

    Matthias Zebisch;Yang Xu;Yang Xu;Christos Krastev;Bryan T. MacDonald

  • Molecular Determinants of Sphingomyelin Specificity of a Eukaryotic Pore-forming Toxin *

    Biserka Bakrač;Ion Gutiérrez-Aguirre;Zdravko Podlesek;Andreas F.-P. Sonnen

  • Structure of the Fungal Beta-Glucan-Binding Immune Receptor Dectin-1: Implications for Function.

    J. Brown;C.A. O'Callaghan;A.S.J. Marshall;R.J.C. Gilbert

  • Dual interaction of JAM-C with JAM-B and alpha(M)beta2 integrin: function in junctional complexes and leukocyte adhesion.

    Chrystelle Lamagna;Paolo Meda;Guillaume Mandicourt;James Brown

Frequent Co-Authors

David I. Stuart
David I. Stuart University of Oxford
Gregor Anderluh
Gregor Anderluh University of Ljubljana
Christian Siebold
Christian Siebold University of Oxford
Karl Harlos
Karl Harlos University of Oxford
Peter W. Andrew
Peter W. Andrew University of Leicester
Simon J. Davis
Simon J. Davis University of Oxford
David J. Rowlands
David J. Rowlands University of Leeds
Ian Brierley
Ian Brierley University of Cambridge
Mauro Dalla Serra
Mauro Dalla Serra Consiglio Nazionale delle Ricerche - CNR
Raymond J. Owens
Raymond J. Owens University of Oxford

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