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Molecular Biology

D-Index
45
Citations
8494
World Ranking
2858
National Ranking
227

Overview

Ian Brierley is a researcher affiliated with the University of Cambridge in the United Kingdom. Their work primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions to Medicine. Within these broad domains, they focus notably on Molecular Biology and intersect with areas such as Cardiology and Cardiovascular Medicine, Infectious Diseases, Ecology, and Animal Science and Zoology.

The central themes in Brierley's research include RNA and protein synthesis mechanisms, Viral Infections and Immunology Research, Viral gastroenteritis research and epidemiology, RNA modifications and cancer, Bacteriophages and microbial interactions, RNA research and splicing, and Animal Virus Infections Studies.

Brierley has a range of recent publications demonstrating a focus on molecular virology and RNA biology. Notable papers include:

  • An RNA thermoswitch regulates daytime growth in Arabidopsis (2020), published in Nature Plants
  • Manipulation of the unfolded protein response: A pharmacological strategy against coronavirus infection (2021), published in PLoS Pathogens
  • Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection (2020), published in Cell
  • Modulation of Viral Programmed Ribosomal Frameshifting and Stop Codon Readthrough by the Host Restriction Factor Shiftless (2021), published in Viruses
  • Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch (2021), published in Nature Communications

The venues where Brierley publishes also reflect their research focus and collaborations. They frequently contribute to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Plants
  • PLoS Pathogens
  • Annual Review of Virology

Brierley's frequent co-authors include:

  • Andrew E. Firth
  • Chris H. Hill
  • Georgia M. Cook
  • Sawsan Napthine
  • Stephen C. Graham

Best Publications

  • Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot.

    Ian Brierley;Paul Digard;Stephen C. Inglis

  • Non-canonical translation in RNA viruses.

    Andrew E. Firth;Ian Brierley

  • An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV.

    I. Brierley;M. E. G. Boursnell;M. M. Binns;B. Bilimoria

  • A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting

    Olivier Namy;Stephen J. Moran;David I. Stuart;Robert J. C. Gilbert

  • Ribosomal frameshifting on viral RNAs

    Ian Brierley

  • Mutational analysis of the "slippery-sequence" component of a coronavirus ribosomal frameshifting signal.

    Ian Brierley;Alison J. Jenner;Stephen C. Inglis

  • Ribosomal pausing during translation of an RNA pseudoknot.

    P Somogyi;A J Jenner;I Brierley;S C Inglis

  • Reprogrammed genetic decoding in cellular gene expression

    Olivier Namy;Jean-Pierre Rousset;Sawsan Napthine;Ian Brierley

  • Viral RNA pseudoknots: versatile motifs in gene expression and replication.

    Ian Brierley;Simon Pennell;Robert J C Gilbert

  • Ribosomal pausing at a frameshifter RNA pseudoknot is sensitive to reading phase but shows little correlation with frameshift efficiency.

    Harry Kontos;Sawsan Napthine;Ian Brierley

  • Programmed ribosomal frameshifting in HIV-1 and the SARS–CoV

    Ian Brierley;Francisco J. Dos Ramos

  • Mutational analysis of the RNA pseudoknot component of a coronavirus ribosomal frameshifting signal

    Ian Brierley;Nicola J. Rolley;Alison J. Jenner;Stephen C. Inglis

  • High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling

    Nerea Irigoyen;Andrew E. Firth;Joshua D. Jones;Betty Y.-W. Chung

  • An RNA thermoswitch regulates daytime growth in Arabidopsis.

    Betty Y. W. Chung;Martin Balcerowicz;Marco Di Antonio;Katja E. Jaeger;Katja E. Jaeger

  • Transactivation of programmed ribosomal frameshifting by a viral protein.

    Yanhua Li;Emmely E. Treffers;Sawsan Napthine;Ali Tas

  • The human astrovirus RNA-dependent RNA polymerase coding region is expressed by ribosomal frameshifting.

    B. Marczinke;A. J. Bloys;T. D. K. Brown;M. M. Willcocks

  • Characterization of the frameshift signal of Edr, a mammalian example of programmed -1 ribosomal frameshifting.

    Emily Manktelow;Kazuhiro Shigemoto;Ian Brierley

  • The use of duplex-specific nuclease in ribosome profiling and a user-friendly software package for Ribo-seq data analysis

    Betty Y. Chung;Thomas J. Hardcastle;Joshua D. Jones;Nerea Irigoyen

  • Expression of a coronavirus ribosomal frameshift signal in Escherichia coli: influence of tRNA anticodon modification on frameshifting

    Ian Brierley;Michayla R Meredith;Alison J Bloys;Tord G Hagervall

  • The role of RNA pseudoknot stem 1 length in the promotion of efficient -1 ribosomal frameshifting

    Sawsan Napthine;Jan Liphardt;Alison Bloys;Samantha Routledge

Frequent Co-Authors

Andrew E. Firth
Andrew E. Firth University of Cambridge
Robert J. C. Gilbert
Robert J. C. Gilbert University of Oxford
Stuart G. Siddell
Stuart G. Siddell University of Bristol
Geoffrey L. Smith
Geoffrey L. Smith University of Oxford
Philip J. R. Goulder
Philip J. R. Goulder University of Oxford
Polly Roy
Polly Roy London School of Hygiene & Tropical Medicine
Paul Digard
Paul Digard University of Edinburgh
Eric J. Snijder
Eric J. Snijder Leiden University Medical Center
Ian Goodfellow
Ian Goodfellow University of Cambridge
Michal Minczuk
Michal Minczuk University of Cambridge

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