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Neuroscience

D-Index
39
Citations
10259
World Ranking
8216
National Ranking
3522

Overview

Sheila M. Fleming is affiliated with the University of Cincinnati in the United States. Their research primarily spans the fields of Medicine and Neuroscience, with a focus on several subfields including Neurology, Physiology, Molecular Biology, Cognitive Neuroscience, and Cellular and Molecular Neuroscience.

The main topics of their research work include:

  • Parkinson's Disease Mechanisms and Treatments
  • Alzheimer's disease research and treatments
  • Neurological disorders and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Lysosomal Storage Disorders Research
  • Nuclear Receptors and Signaling
  • Conducting polymers and applications

Their recent publications cover a range of topics relating to neurodegenerative diseases and treatments, including:

  • Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits, 2020, Neurobiology of Disease
  • Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis, 2020, Epigenetics
  • Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice, 2021, Neuropathology and Applied Neurobiology
  • Targeting alpha-synuclein via the immune system in Parkinson's disease: Current vaccine therapies, 2021, Neuropharmacology
  • Alpha-synuclein pathology, microgliosis, and parvalbumin neuron loss in the amygdala associated with enhanced fear in the Thy1-aSyn model of Parkinson's disease, 2021, Neurobiology of Disease

Fleming's frequent co-authors include Danielle Herman, Allyson Cole-Strauss, Christopher J. Kemp, Joseph R. Patterson, and Kathryn Miller.

The researcher has published multiple papers in the following venues:

  • Neurobiology of Disease
  • Journal of Biological Chemistry
  • Epigenetics
  • Neuropathology and Applied Neurobiology
  • Neuropharmacology

Best Publications

  • CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury.

    Timothy Schallert;Sheila M Fleming;J.Leigh Leasure;Jennifer L Tillerson

  • A Neurovascular Niche for Neurogenesis after Stroke

    J. J. Ohab;S. Fleming;A. Blesch;S. T. Carmichael

  • Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

    Matthew S. Goldberg;Sheila M. Fleming;James J. Palacino;Carlos Cepeda

  • Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein

    Sheila M. Fleming;Jonathan Salcedo;Pierre-Olivier Fernagut;Edward Rockenstein

  • Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

    Katrina L. Paumier;Kelvin C. Luk;Fredric P. Manfredsson;Nicholas M. Kanaan

  • Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells

    I. Castagliuolo;J. T. Lamont;B. Qiu;S. M. Fleming

  • Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone

    Sheila M Fleming;Chunni Zhu;Pierre-Olivier Fernagut;Arpesh Mehta

  • Olfactory deficits in mice overexpressing human wildtype α‐synuclein

    Sheila M. Fleming;Nicole A. Tetreault;Caitlin K. Mulligan;Ché B. Hutson

  • Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-Dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-Resistant α-Synuclein

    Xiao Hong Lu;Sheila M. Fleming;Bernhard Meurers;Larry C. Ackerson

  • Behavioral and histopathological consequences of paraquat intoxication in mice: Effects of α‐synuclein over‐expression

    P.O. Fernagut;C.B. Hutson;S.M. Fleming;N.A. Tetreaut

  • Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect.

    Michael S. Levine;Carlos Cepeda;Miriam A. Hickey;Sheila M. Fleming

  • Genetic Mouse Models of Parkinsonism: Strengths and Limitations

    Sheila M. Fleming;Pierre-Olivier Fernagut;Marie-Françoise Chesselet

  • 3,4-Dihydroxyphenylalanine Reverses the Motor Deficits in Pitx3-Deficient Aphakia Mice: Behavioral Characterization of a Novel Genetic Model of Parkinson's Disease

    Dong-Youn Hwang;Sheila M Fleming;Paul Ardayfio;Taylor Moran-Gates

  • HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease

    C Savio Chan;Kelly E Glajch;Tracy S Gertler;Jaime N Guzman

  • Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson’s disease

    Kelly E. Glajch;Sheila M. Fleming;D. James Surmeier;Pavel Osten

  • Assessment of sensorimotor function in mouse models of Parkinson's disease.

    Sheila M. Fleming;Osunde R. Ekhator;Valentins Ghisays

  • Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

    Patrick J. Schultheis;Sheila M. Fleming;Amy K. Clippinger;Jada Lewis

  • Abnormal colonic motility in mice overexpressing human wild-type α-synuclein

    Lixin Wang;Sheila M. Fleming;Marie-Françoise Chesselet;Yvette Taché

  • Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice

    Jessica M. Froula;Marta Castellana-Cruz;Nadia M. Anabtawi;José D. Camino

  • BEHAVIORAL EFFECTS OF DOPAMINERGIC AGONISTS IN TRANSGENIC MICE OVEREXPRESSING HUMAN WILDTYPE α-SYNUCLEIN

    S.M. Fleming;J. Salcedo;C.B. Hutson;E. Rockenstein

  • Variable effects of chronic subcutaneous administration of rotenone on striatal histology.

    Chunni Zhu;Patrick Vourc'h;Pierre‐Olivier Fernagut;Sheila M. Fleming

Frequent Co-Authors

Marie-Françoise Chesselet
Marie-Françoise Chesselet University of California, Los Angeles
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Timothy J Schallert
Timothy J Schallert The University of Texas at Austin
Pierre-Olivier Fernagut
Pierre-Olivier Fernagut University of Poitiers
Michael S. Levine
Michael S. Levine Princeton University
Pavel Osten
Pavel Osten Cold Spring Harbor Laboratory
Caryl E. Sortwell
Caryl E. Sortwell Michigan State University
D. James Surmeier
D. James Surmeier Northwestern University
Michal K. Stachowiak
Michal K. Stachowiak University at Buffalo, State University of New York
Nigel T. Maidment
Nigel T. Maidment University of California, Los Angeles

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