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Biology and Biochemistry

D-Index
74
Citations
21547
World Ranking
5549
National Ranking
429

Overview

Simon J. Davis is primarily affiliated with the University of Oxford in the United Kingdom. Their research spans multiple domains within immunology and related biomedical sciences, reflecting a significant body of work across several interconnected fields of study.

The main fields of study in which Simon J. Davis has contributed include Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these areas, their work further delves into specialized subfields such as Immunology, Oncology, Biophysics, Radiology, Nuclear Medicine and Imaging, and Molecular Biology.

Simon J. Davis has explored a variety of research topics, with a particular focus on T-cell and B-cell Immunology, Immune Cell Function and Interaction, and CAR-T cell therapy research. Additional topics covered include Monoclonal and Polyclonal Antibodies Research, Advanced Fluorescence Microscopy Techniques, Immunotherapy and Immune Responses, and Advanced Electron Microscopy Techniques and Applications.

Their recent published papers highlight ongoing investigations into the mechanisms of immune regulation and cellular interactions. Notable recent publications include:

  • Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation, 2022, Nature Immunology
  • Structure of a fully assembled tumor-specific T cell receptor ligated by pMHC, 2022, Cell
  • PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition, 2021, Nature Communications
  • The current state and future of T-cell exhaustion research, 2023, Oxford Open Immunology
  • Coreceptors and TCR Signaling - the Strong and the Weak of It, 2020, Frontiers in Cell and Developmental Biology

Simon J. Davis frequently collaborates with several other researchers. Their top co-authors include Ana Mafalda Santos, David Klenerman, Edward Jenkins, Steven F. Lee, and James McColl.

Their work is disseminated through various prominent publication venues which include bioRxiv (Cold Spring Harbor Laboratory), Biophysical Journal, Brain Stimulation, Proceedings of the National Academy of Sciences, and Nature Communications. These venues reflect a consistent engagement with journals that cover immunology, biophysics, and biomedical sciences.

Best Publications

  • The interaction properties of costimulatory molecules revisited.

    Alison V. Collins;Douglas W. Brodie;Robert J.C. Gilbert;Andrea Iaboni

  • CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

    P A van der Merwe;D L Bodian;S Daenke;P Linsley

  • Colonic epithelial cell diversity in health and inflammatory bowel disease

    Kaushal Parikh;Kaushal Parikh;Agne Antanaviciute;Agne Antanaviciute;David Fawkner-Corbett;David Fawkner-Corbett;David Fawkner-Corbett;Marta Jagielowicz;Marta Jagielowicz

  • The kinetic-segregation model: TCR triggering and beyond

    S J Davis;P A van der Merwe

  • Molecular Interactions Mediating T Cell Antigen Recognition

    P. Anton van der Merwe;Simon J. Davis

  • Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

    Carin C. Stamper;Yan Zhang;James F. Tobin;David V. Erbe

  • The structure and ligand interactions of CD2: implications for T-cell function

    S J Davis;P A van der Merwe

  • A late Middle Pleistocene Denisovan mandible from the Tibetan Plateau

    Fahu Chen;Fahu Chen;Frido Welker;Frido Welker;Frido Welker;Chuan Chou Shen;Shara E. Bailey;Shara E. Bailey

  • TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

    Adam P. Gregory;Calliope A. Dendrou;Kathrine E. Attfield;Aiden Haghikia;Aiden Haghikia

  • The immunological synapse and CD28-CD80 interactions

    Shannon K. Bromley;Andrea Iaboni;Simon J. Davis;Adrian Whitty

  • Structure and Interactions of the Human Programmed Cell Death 1 Receptor

    Xiaoxiao Cheng;Vaclav Veverka;Anand Radhakrishnan;Lorna C. Waters

  • Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.

    E Y Jones;S J Davis;A F Williams;K Harlos

  • A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer

    John R James;Marta I Oliveira;Marta I Oliveira;Alexandre M Carmo;Alexandre M Carmo;Andrea Iaboni

  • Glycoprotein Structural Genomics: Solving the Glycosylation Problem

    V T Chang;M Crispin;M Crispin;A R Aricescu;D J Harvey

  • Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition.

    P.Anton van der Merwe;Simon J. Davis;Andrey S. Shaw;Michael L. Dustin

  • Initiation of T cell signaling by CD45 segregation at 'close contacts'

    Veronica T Chang;Ricardo A Fernandes;Kristina A Ganzinger;Steven F Lee

  • The 2015 super-resolution microscopy roadmap

    Stefan W. Hell;Stefan W. Hell;Steffen J. Sahl;Mark Bates;Xiaowei Zhuang

  • The nature of molecular recognition by T cells

    Simon J. Davis;Shinji Ikemizu;Edward J. Evans;Lars Fugger

  • The 2015 super-resolution microscopy roadmap

    Stefan Hell;Steffen Sahl;Mark Bates;Xiaowei Zhuang

  • Structure and dimerization of a soluble form of B7-1.

    S Ikemizu;R J Gilbert;R J Gilbert;J A Fennelly;A V Collins

Frequent Co-Authors

David Klenerman
David Klenerman University of Cambridge
David I. Stuart
David I. Stuart University of Oxford
E Y Jones
E Y Jones University of Oxford
Roman Fischer
Roman Fischer University of Oxford
Benedikt M. Kessler
Benedikt M. Kessler University of Oxford
Michael L. Dustin
Michael L. Dustin University of Oxford
A N Barclay
A N Barclay University of Oxford
P. Anton van der Merwe
P. Anton van der Merwe University of Oxford
Karl Harlos
Karl Harlos University of Oxford
Alan F. Williams
Alan F. Williams University of Oxford

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