His primary areas of investigation include T cell, CD28, Receptor, Cell biology and Biophysics. His study in T cell focuses on T-cell receptor in particular. In his research on the topic of CD28, CD86 is strongly related with CD80.
His work deals with themes such as Protein structure, Plasma protein binding and Protein–protein interaction, which intersect with Receptor. While the research belongs to areas of Cell biology, Simon J. Davis spends his time largely on the problem of Antigen-presenting cell, intersecting his research to questions surrounding Interleukin 21 and Interleukin 12. His studies deal with areas such as CD58, Integrin, SEMA4D and Homology as well as Biophysics.
Simon J. Davis mainly focuses on Cell biology, Receptor, Biophysics, T-cell receptor and T cell. His Cell biology research is multidisciplinary, incorporating perspectives in Cell, Immune system and Antigen. His Biophysics study incorporates themes from Plasma protein binding, Lipid bilayer, Stereochemistry and Membrane protein.
His studies in T-cell receptor integrate themes in fields like Jurkat cells, Major histocompatibility complex and Protein tyrosine phosphatase, Phosphorylation. His work carried out in the field of T cell brings together such families of science as Molecular biology, Glycoprotein and CD8. His CD28 research focuses on subjects like CD80, which are linked to Cell adhesion molecule.
His primary areas of study are Cell biology, Receptor, T-cell receptor, Biophysics and Cell. His Cell biology study incorporates themes from Ubiquitin, Immune system and Proteomics. His biological study spans a wide range of topics, including T cell, Immunosuppression, Melanoma, Förster resonance energy transfer and Immunoglobulin E.
Simon J. Davis performs multidisciplinary study in the fields of T cell and Ligand via his papers. His studies deal with areas such as Protein tyrosine phosphatase, CD8, Major histocompatibility complex, Antigen and Low affinity as well as T-cell receptor. The various areas that Simon J. Davis examines in his Biophysics study include Lipid bilayer, Membrane protein and Calcium signaling.
The scientist’s investigation covers issues in Cell biology, Receptor, T-cell receptor, Proteomics and Immune system. His Cell biology research is multidisciplinary, incorporating elements of Inflammation, Intestinal mucosa and Antigen. Simon J. Davis studied Receptor and Cell that intersect with Kinase.
His T-cell receptor study results in a more complete grasp of T cell. His research in T cell intersects with topics in CD3, Intracellular and Förster resonance energy transfer. Simon J. Davis combines subjects such as Immunoglobulin E, Neuroscience, Monoclonal antibody and Phosphatase with his study of Immune system.
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The interaction properties of costimulatory molecules revisited.
Alison V. Collins;Douglas W. Brodie;Robert J.C. Gilbert;Andrea Iaboni.
CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics
P A van der Merwe;D L Bodian;S Daenke;P Linsley.
Journal of Experimental Medicine (1997)
Molecular Interactions Mediating T Cell Antigen Recognition
P. Anton van der Merwe;Simon J. Davis.
Annual Review of Immunology (2003)
The structure and ligand interactions of CD2: implications for T-cell function
S J Davis;P A van der Merwe.
Immunology Today (1996)
Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses
Carin C. Stamper;Yan Zhang;James F. Tobin;David V. Erbe.
The kinetic-segregation model: TCR triggering and beyond.
S J Davis;P A van der Merwe.
Nature Immunology (2006)
TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
Adam P. Gregory;Calliope A. Dendrou;Kathrine E. Attfield;Aiden Haghikia;Aiden Haghikia.
Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
E Y Jones;S J Davis;A F Williams;K Harlos.
The immunological synapse and CD28-CD80 interactions
Shannon K. Bromley;Andrea Iaboni;Simon J. Davis;Adrian Whitty.
Nature Immunology (2001)
A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer
John R James;Marta I Oliveira;Marta I Oliveira;Alexandre M Carmo;Alexandre M Carmo;Andrea Iaboni.
Nature Methods (2006)
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