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Microbiology

D-Index
63
Citations
12058
World Ranking
2788
National Ranking
1112

Overview

Rodney K. Tweten is affiliated with the University of Oklahoma Health Sciences Center in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on Public Health, Environmental and Occupational Health, Molecular Biology, Infectious Diseases, Epidemiology, and Ecology.

Their work covers several main topics, including Streptococcal Infections and Treatments, Pneumonia and Respiratory Infections, Bacteriophages and microbial interactions, Antimicrobial Resistance in Staphylococcus, Bacterial Infections and Vaccines, Clostridium difficile and Clostridium perfringens research, and Neonatal and Maternal Infections.

Rodney K. Tweten has contributed to a number of scientific papers. Some of the recent publications include:

  • A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response (2022, Nature Communications)
  • A Key Motif in the Cholesterol-Dependent Cytolysins Reveals a Large Family of Related Proteins (2020, mBio)
  • Cholesterol-dependent cytolysins: The outstanding questions (2022, IUBMB Life)
  • A listeriolysin O subunit vaccine is protective against Listeria monocytogenes (2020, Vaccine)
  • Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin (2023, Infection and Immunity)

Frequent coauthors in Rodney K. Tweten's research include Bronte A. Johnstone, Craig J. Morton, Michelle P. Christie, Michael W. Parker, and Jordan C. Evans.

The scientist's work has been published in various venues multiple times. Notable frequent publication venues are:

  • Acta Crystallographica Section A Foundations and Advances (4 publications)
  • Nature Communications (2 publications)
  • Vaccine (2 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (2 publications)
  • mBio (1 publication)

Best Publications

  • Cholesterol-Dependent Cytolysins, a Family of Versatile Pore-Forming Toxins

    Rodney K. Tweten

  • Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form.

    Jamie Rossjohn;Susanne C Feil;William J McKinstry;Rodney K Tweten

  • Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy.

    Laura A. Shepard;Alejandro P. Heuck;Brian D. Hamman;Jamie Rossjohn

  • The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins.

    Oleg Shatursky;Alejandro P Heuck;Laura A Shepard;Jamie Rossjohn

  • Vertical collapse of a cytolysin prepore moves its transmembrane β‐hairpins to the membrane

    Daniel M Czajkowsky;Eileen M Hotze;Zhifeng Shao;Rodney K Tweten

  • Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin

    Kara S Giddings;Ji Zhao;Peter J Sims;Rodney K Tweten

  • Redefining cholesterol's role in the mechanism of the cholesterol-dependent cytolysins

    Kara S. Giddings;Arthur E. Johnson;Rodney K. Tweten

  • Structural insights into the membrane-anchoring mechanism of a cholesterol-dependent cytolysin.

    Rajesh Ramachandran;Alejandro P. Heuck;Rodney K. Tweten;Arthur E. Johnson

  • Molecular basis of listeriolysin O pH dependence

    Daniel W. Schuerch;Elizabeth M. Wilson-Kubalek;Rodney K. Tweten

  • Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface

    Allison J. Farrand;Stephanie LaChapelle;Eileen M. Hotze;Arthur E. Johnson

  • Membrane assembly of the cholesterol-dependent cytolysin pore complex.

    Eileen M. Hotze;Rodney K. Tweten

  • The Mechanism of Pore Assembly for a Cholesterol-Dependent Cytolysin: Formation of a Large Prepore Complex Precedes the Insertion of the Transmembrane β-Hairpins†

    Laura A. Shepard;Oleg Shatursky;and Arthur E. Johnson;Rodney K. Tweten

  • Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin

    Galina Polekhina;Kara Sue Giddings;Rodney K Tweten;Michael William Parker

  • Membrane-dependent conformational changes initiate cholesterol-dependent cytolysin oligomerization and intersubunit β-strand alignment

    Rajesh Ramachandran;Rodney K Tweten;Arthur E Johnson

  • Mechanism of Membrane Insertion of a Multimeric β-Barrel Protein: Perfringolysin O Creates a Pore Using Ordered and Coupled Conformational Changes

    Alejandro P Heuck;Eileen M Hotze;Rodney K Tweten;Arthur E Johnson

  • The Cholesterol-Dependent Cytolysins

    R. K. Tweten;M. W. Parker;A. E. Johnson

  • Clostridium septicum alpha toxin uses glycosylphosphatidylinositol-anchored protein receptors.

    Valery M. Gordon;Kim L. Nelson;J. Thomas Buckley;Victoria L. Stevens

  • Beta-barrel pore-forming toxins: intriguing dimorphic proteins.

    Alejandro P. Heuck;Rodney K. Tweten;Arthur E. Johnson

  • Arresting Pore Formation of a Cholesterol-dependent Cytolysin by Disulfide Trapping Synchronizes the Insertion of the Transmembrane β-Sheet from a Prepore Intermediate

    Eileen M. Hotze;Elizabeth M. Wilson-Kubalek;Jamie Rossjohn;Michael W. Parker

  • Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions

    Casie E. Soltani;Eileen M. Hotze;Arthur E. Johnson;Rodney K. Tweten

  • Nucleotide sequence of the gene for perfringolysin O (theta-toxin) from Clostridium perfringens: significant homology with the genes for streptolysin O and pneumolysin.

    R K Tweten

Frequent Co-Authors

Michael W. Parker
Michael W. Parker University of Melbourne
Arthur E. Johnson
Arthur E. Johnson Texas A&M University
Jamie Rossjohn
Jamie Rossjohn Monash University
Dennis L. Stevens
Dennis L. Stevens University of Washington
Peter J. Sims
Peter J. Sims University of Rochester
Amy E. Bryant
Amy E. Bryant Idaho State University
James C. Paton
James C. Paton University of Adelaide
Elaine I. Tuomanen
Elaine I. Tuomanen St. Jude Children's Research Hospital
Mark R. Alderson
Mark R. Alderson Program for Appropriate Technology in Health
Julian I. Rood
Julian I. Rood Monash University

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