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Microbiology
Australia
2026

D-Index & Metrics

Microbiology

D-Index
115
Citations
44085
World Ranking
195
National Ranking
3

Medicine

D-Index
115
Citations
44093
World Ranking
4589
National Ranking
127

Research.com Recognitions

  • 2026 - Research.com Microbiology in Australia Leader Award
  • 2025 - Research.com Microbiology in Australia Leader Award
  • 2023 - Research.com Microbiology in Australia Leader Award
  • 2022 - Research.com Microbiology in Australia Leader Award
  • 2013 - Fellow of the Australian Academy of Science

Overview

James C. Paton is affiliated with the University of Adelaide in Australia and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields including molecular biology, epidemiology, cell biology, immunology, and microbiology.

Paton's research focuses on several key topics, notably:

  • Endoplasmic Reticulum Stress and Disease
  • Pneumonia and Respiratory Infections
  • Bacterial Infections and Vaccines
  • Monoclonal and Polyclonal Antibodies Research
  • Antibiotic Resistance in Bacteria
  • Streptococcal Infections and Treatments
  • Glycosylation and Glycoproteins Research

Frequent co-authors collaborating with Paton include:

  • Adrienne W. Paton (39 joint publications)
  • Claudia Trappetti (19 joint publications)
  • Erin B. Brazel (14 joint publications)
  • Vikrant Minhas (8 joint publications)
  • Bart A. Eijkelkamp (8 joint publications)

The scientist has published numerous papers across well-known venues. The most frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory) with 14 publications
  • mBio with 4 publications
  • Journal of Biological Chemistry with 4 publications
  • Zenodo (CERN European Organization for Nuclear Research) with 4 publications
  • FEBS Journal with 2 publications

Notable papers authored or co-authored by James C. Paton include:

  • "Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling" (2020, eLife)
  • "Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum" (2020, Blood)
  • "Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut" (2023, Immunity)
  • "IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress" (2020, The Journal of Cell Biology)
  • "All major cholesterol-dependent cytolysins use glycans as cellular receptors" (2020, Science Advances)

James C. Paton was recognized as a Fellow of the Australian Academy of Science in 2013.

Best Publications

  • Pathogenesis and Diagnosis of Shiga Toxin-Producing Escherichia coli Infections

    James C. Paton;Adrienne W. Paton

  • Detection and characterization of Shiga toxigenic Escherichia coli by using multiplex PCR assays for stx1, stx2, eaeA, enterohemorrhagic E. coli hlyA, rfbO111, and rfbO157

    Adrienne W. Paton;James C. Paton

  • The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease.

    Aras Kadioglu;Jeffrey N. Weiser;James C. Paton;Peter W. Andrew

  • Streptococcus pneumoniae: transmission, colonization and invasion

    Jeffrey N. Weiser;Daniela M. Ferreira;James C. Paton

  • Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.

    Richard Malley;Philipp Henneke;Sarah C. Morse;Michael J. Cieslewicz

  • Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.

    Min Lu;David A. Lawrence;Scot Marsters;Diego Acosta-Alvear

  • Antibody Response to Pneumococcal Vaccination in Children Younger than Five Years of Age

    R. M. Douglas;J. C. Paton;S. J. Duncan;D. J. Hansman

  • A Molecular Mechanism for Bacterial Susceptibility to Zinc.

    Christopher A. McDevitt;Abiodun D. Ogunniyi;Eugene Valkov;Michael C. Lawrence

  • The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

    Jeremy S. Brown;Tracy Hussell;Sarah M. Gilliland;David W. Holden

  • Direct Detection and Characterization of Shiga Toxigenic Escherichia coli by Multiplex PCR for stx1, stx2, eae, ehxA, and saa

    Adrienne W. Paton;James C. Paton

  • Characterization of Saa, a Novel Autoagglutinating Adhesin Produced by Locus of Enterocyte Effacement-Negative Shiga-Toxigenic Escherichia coli Strains That Are Virulent for Humans

    Adrienne W. Paton;Potjanee Srimanote;Matthew C. Woodrow;James C. Paton

  • Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.

    A M Berry;J Yother;D E Briles;D Hansman

  • Molecular microbiological investigation of an outbreak of hemolytic-uremic syndrome caused by dry fermented sausage contaminated with Shiga-like toxin-producing Escherichia coli.

    A W Paton;R M Ratcliff;R M Doyle;J Seymour-Murray

  • AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

    Adrienne W Paton;Travis Clarke Beddoe;Cheleste M Thorpe;James Whisstock

  • Recombinational exchanges at the capsular polysaccharide biosynthetic locus lead to frequent serotype changes among natural isolates of Streptococcus pneumoniae

    Tracey J. Coffey;Mark C. Enright;Maggie Daniels;Judy K. Morona

  • Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae.

    David E. Briles;Eddie Ades;James C. Paton;Jacquelyn S. Sampson

  • A New Family of Potent AB5 Cytotoxins Produced by Shiga Toxigenic Escherichia coli

    Adrienne W. Paton;Potjanee Srimanote;Ursula M. Talbot;Hui Wang

  • MOLECULAR ANALYSIS OF THE PATHOGENICITY OF STREPTOCOCCUS-PNEUMONIAE - THE ROLE OF PNEUMOCOCCAL PROTEINS

    Jc Paton;Pw Andrew;Gj Boulnois;Tj Mitchell

  • Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae.

    A M Berry;J C Paton

  • Contribution of autolysin to virulence of Streptococcus pneumoniae.

    A M Berry;R A Lock;D Hansman;J C Paton

Frequent Co-Authors

Adrienne W. Paton
Adrienne W. Paton University of Adelaide
Renato Morona
Renato Morona University of Adelaide
Peter W. Andrew
Peter W. Andrew University of Leicester
David E. Briles
David E. Briles University of Alabama at Birmingham
Timothy J. Mitchell
Timothy J. Mitchell University of Birmingham
Michael P. Jennings
Michael P. Jennings Griffith University
Tobias Welte
Tobias Welte University of Hannover
Alastair G. McEwan
Alastair G. McEwan University of Queensland
Jamie Rossjohn
Jamie Rossjohn Monash University
Shaun R. McColl
Shaun R. McColl University of Adelaide

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