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Chemistry

D-Index
65
Citations
15589
World Ranking
7637
National Ranking
2236

Overview

Mark C. Manning is affiliated with Colorado State University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Engineering.

Their scholarly output includes work published in several scientific journals, reflecting a focus on pharmaceutical sciences, protein stability, and structural biology. Frequent publication venues include:

  • Journal of Pharmaceutical Sciences
  • Current Protein and Peptide Science
  • Pharmaceutical Research
  • PCI Journal
  • Patient Education and Counseling

The main topics Mark C. Manning's research covers are:

  • Protein purification and stability
  • Monoclonal and Polyclonal Antibodies Research
  • Field-Flow Fractionation Techniques
  • Protein Structure and Dynamics
  • Drug Solubility and Delivery Systems
  • Thermodynamics and calorimetric analyses
  • Advanced Thermodynamic Systems and Engines

The scientist's recent papers include:

  • Stability of Protein Pharmaceuticals: Recent Advances, 2024, Pharmaceutical Research
  • Application of Formulation Principles to Stability Issues Encountered During Processing, Manufacturing, and Storage of Drug Substance and Drug Product Protein Therapeutics, 2023, Journal of Pharmaceutical Sciences
  • Analysis of Peptides using Asymmetrical Flow Field-flow Fractionation (AF4), 2021, Journal of Pharmaceutical Sciences
  • A novel reinforced-concrete buckling-restrained brace for precast concrete lateral-load-resisting frames, 2023, PCI Journal
  • Chemometric Study of the Relative Aggregation Propensity of Position 19Mutants of Aβ(1-42), 2022, Current Protein and Peptide Science

Frequent collaborators in their work include:

  • Charles S. Henry
  • Ryan E. Holcomb
  • Derrick S. Katayama
  • R. W. Payne
  • Joshua M. Stillahn

Mark C. Manning's research integrates multiple subfields such as Molecular Biology, Radiology, Nuclear Medicine and Imaging, Computational Mechanics, Civil and Structural Engineering, and Pharmaceutical Science. This multidisciplinary approach supports investigations in protein pharmaceuticals, structural mechanics, and therapeutic drug development.

Best Publications

  • Stability of Protein Pharmaceuticals

    Mark C. Manning;Kamlesh Patel;Ronald T. Borchardt

  • Stability of Protein Pharmaceuticals: An Update

    Mark Cornell Manning;Danny K. Chou;Brian M. Murphy;Robert W. Payne

  • Theoretical CD studies of polypeptide helices: examination of important electronic and geometric factors.

    Mark C. Manning;Robert W. Woody

  • Circular dichroism studies of distorted alpha-helices, twisted beta-sheets, and beta turns.

    Mark C. Manning;Mali Illangasekare;Robert W. Woody

  • Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

    Narendra B. Bam;Jeffrey L. Cleland;Janet Yang;Mark C. Manning

  • Effects of Tween 20® and Tween 80® on the Stability of Albutropin During Agitation

    Danny K. Chou;Rajesh Krishnamurthy;Theodore W. Randolph;John F. Carpenter

  • Solubilization of pharmaceutical substances in an organic solvent and preparation of pharmaceutical powders using the same

    Mark C. Manning;Theodore W. Randolph;Eli Shefter;Richard F. Falk

  • Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII.

    Lotte Kreilgaard;Latoya S. Jones;Latoya S. Jones;Theodore W. Randolph;Sven Frokjaer

  • Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: Role in restricted conformational mobility and compaction of native state

    Brent S. Kendrick;Byeong S. Chang;Tsutomu Arakawa;Brian Peterson

  • The helix-coil transition in heterogeneous peptides with specific side-chain interactions: theory and comparison with CD spectral data.

    Paul J. Gans;Pingchiang C. Lyu;Mark C. Manning;Robert W. Woody

  • Hydrophobic Ion Pairing: Altering the Solubility Properties of Biomolecules

    Jeffrey D. Meyer;Mark C. Manning

  • Controlled release of ionic compounds from poly (l-lactide) microspheres produced by precipitation with a compressed antisolvent

    Rick Falk;Theodore W Randolph;Jeffrey D Meyer;R.Michael Kelly

  • Sustained-release composition including amorphous polymer

    Theodore W. Randolph;Mark C. Manning;Richard F. Falk

  • Theoretical study of the contribution of aromatic side chains to the circular dichroism of basic bovine pancreatic trypsin inhibitor.

    Mark C. Manning;Robert W. Woody

  • Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.

    Sampathkumar Krishnan;Eva Y. Chi;Jonathan N. Webb;Byeong S. Chang

  • Quantitation of the Area of Overlap between Second-Derivative Amide I Infrared Spectra To Determine the Structural Similarity of a Protein in Different States

    Brent S. Kendrick;Aichun Dong;S. Dean Allison;Mark C. Manning

  • Role of Buffers in Protein Formulations

    Teddy J. Zbacnik;Ryan E. Holcomb;Derrick S. Katayama;Brian M. Murphy

  • Infrared and circular dichroism spectroscopic characterization of structural differences between beta-lactoglobulin A and B.

    A Dong;J Matsuura;S D Allison;E Chrisman

  • Aggregation of Recombinant Human Interferon Gamma: Kinetics and Structural Transitions

    Brent S. Kendrick;Jeffrey L. Cleland;Xanthe Lam;Tue Nguyen

  • Rational design of stable protein formulations : theory and practice

    John F. Carpenter;Mark C. Manning

  • Inhibition of stress-induced aggregation of protein therapeutics.

    John F. Carpenter;Brent S. Kendrick;Byeong S. Chang;Mark C. Manning

Frequent Co-Authors

John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Theodore W. Randolph
Theodore W. Randolph University of Colorado Boulder
Robert W. Woody
Robert W. Woody Colorado State University
Charles S. Henry
Charles S. Henry Colorado State University
Stephen J. Withrow
Stephen J. Withrow Colorado State University
Yong Sung Kim
Yong Sung Kim Ajou University
Jack L. Strominger
Jack L. Strominger Harvard University
Jan P. Kraus
Jan P. Kraus University of Colorado Denver
Jack Henkin
Jack Henkin Northwestern University

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