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Jeffrey L. Cleland

Jeffrey L. Cleland

D-Index & Metrics

Chemistry

D-Index
57
Citations
13068
World Ranking
10995
National Ranking
3009

Research.com Recognitions

  • 2016 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Jeffrey L. Cleland is affiliated with Genentech in the United States and has made contributions across multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work spans several key subfields such as Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, Neurology, and Polymers and Plastics.

The primary topics in their research include:

  • Immune cells in cancer
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dendrimers and Hyperbranched Polymers
  • S100 Proteins and Annexins
  • Alzheimer's disease research and treatments
  • Radiopharmaceutical Chemistry and Applications
  • Nanoplatforms for cancer theranostics

Their recent publications cover a range of subjects relevant to these topics, with selected works including:

  • Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles, 2020, Nature Communications
  • Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer's disease mouse model, 2024, Alzheimer s Research & Therapy
  • Selective targeting of plaque-associated microglia through systemic dendrimer administration in an Alzheimer's disease model, 2020, Alzheimer s & Dementia
  • Clinical Radiosynthesis and Translation of [18F]OP-801: A Novel Radiotracer for Imaging Reactive Microglia and Macrophages, 2023, ACS Chemical Neuroscience
  • Development and Initial Assessment of [18F]OP-801: a Novel Hydroxyl Dendrimer PET Tracer for Preclinical Imaging of Innate Immune Activation in the Whole Body and Brain, 2023, Molecular Imaging and Biology

Frequent co-authors who have collaborated with Jeffrey L. Cleland include:

  • Rishi Sharma
  • Isaac M. Jackson
  • Mackenzie Carlson
  • Samantha T. Reyes
  • E. Carmen Azevedo

The scientist has been published repeatedly in notable venues such as:

  • Alzheimer s & Dementia
  • Cancer Research
  • Nature Communications
  • Alzheimer s Research & Therapy
  • ACS Chemical Neuroscience

Jeffrey L. Cleland was recognized as a Fellow of the Indian National Academy of Engineering (INAE) in 2016.

Best Publications

  • Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

    John Street;Min Bao;Leo deGuzman;Stuart Bunting

  • The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

    Cleland Jl;Powell Mf;Shire Sj

  • A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

    Volker Schellenberger;Chia-wei Wang;Nathan C Geething;Benjamin J Spink

  • A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

    Jeffrey L. Cleland;Xanthe Lam;Brent Kendrick;Janet Yang

  • A month-long effect from a single injection of microencapsulated human growth hormone.

    OluFunmi L. Johnson;Jeffrey L. Cleland;Hye Jung Lee;Margarita Charnis

  • Stable Formulations of Recombinant Human Growth Hormone and Interferon-γ for Microencapsulation in Biodegradable Mircospheres

    Jeffrey L. Cleland;Andrew J. S. Jones

  • Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

    Narendra B. Bam;Jeffrey L. Cleland;Janet Yang;Mark C. Manning

  • Antioxidants for Prevention of Methionine Oxidation in Recombinant Monoclonal Antibody HER2

    Xanthe M. Lam;Janet Y. Yang;Jeffrey L. Cleland

  • The stabilization and encapsulation of human growth hormone into biodegradable microspheres

    OluFunmi L. Johnson;Warren Jaworowicz;Jeffrey L. Cleland;Leonie Bailey

  • Emerging protein delivery methods.

    Jeffrey L Cleland;Ann Daugherty;Randall Mrsny

  • A transient expansion of the native state precedes aggregation of recombinant human interferon-γ

    Brent S. Kendrick;John F. Carpenter;Jeffrey L. Cleland;Theodore W. Randolph

  • Polyethylene glycol enhanced protein refolding.

    Jeffrey L. Cleland;Stuart E. Builder;James R. Swartz;Marjorie Winkler

  • Stability of Protein Formulations: Investigation of Surfactant Effects by a Novel EPR Spectroscopic Technique

    Narendra B. Bam;Theodore W. Randolph;Jeffrey L. Cleland

  • Design and Production of Single-Immunization Vaccines Using Polylactide Polyglycolide Microsphere Systems

    Jeffrey L. Cleland

  • Aggregation of Recombinant Human Interferon Gamma: Kinetics and Structural Transitions

    Brent S. Kendrick;Jeffrey L. Cleland;Xanthe Lam;Tue Nguyen

  • Sustained release of recombinant human insulin-like growth factor-I for treatment of diabetes.

    Xanthe M. Lam;Eileen T. Duenas;Ann L. Daugherty;Nancy Levin

  • Extended recombinant polypeptides and compositions comprising same

    Volker Schellenberger;Joshua Silverman;Chia-wel Wang;Benjamin Spink

  • Excipient stabilization of polypeptides treated with organic solvents

    Jeffrey L. Cleland;Andrew J. S. Jones

  • Single-administration vaccines: controlled-release technology to mimic repeated immunizations.

    Jeffrey L Cleland

  • Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development.

    Jeffrey L Cleland;OluFunmi L Johnson;Scott Putney;Andrew J.S Jones

Frequent Co-Authors

Theodore W. Randolph
Theodore W. Randolph University of Colorado Boulder
John F. Carpenter
John F. Carpenter University of Colorado Anschutz Medical Campus
Justin Hanes
Justin Hanes Johns Hopkins University
Willem P. C. Stemmer
Willem P. C. Stemmer Amunix (United States)
Mark C. Manning
Mark C. Manning Colorado State University
Ronald T. Borchardt
Ronald T. Borchardt University of Kansas
Mark Newman
Mark Newman University of Michigan–Ann Arbor
Daniel I. C. Wang
Daniel I. C. Wang Chinese Academy of Tropical Agricultural Sciences
Peter A. Campochiaro
Peter A. Campochiaro Johns Hopkins University School of Medicine

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