D-Index & Metrics Best Publications
Jeffrey L. Cleland

Jeffrey L. Cleland

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 53 Citations 11,829 108 World Ranking 9283 National Ranking 2689

Research.com Recognitions

Awards & Achievements

2016 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Organic chemistry

His main research concerns Biochemistry, Chromatography, Drug carrier, Protein aggregation and Microsphere. His work deals with themes such as Antibody and Isotonic, which intersect with Biochemistry. Jeffrey L. Cleland has researched Chromatography in several fields, including Trehalose, Polyethylene glycol and Diluent.

Drug carrier is a primary field of his research addressed under Pharmacology. His Protein aggregation research includes themes of Crystallography, Biophysics, Denaturation and Infrared spectroscopy. His Microsphere research incorporates elements of Human growth hormone and Active ingredient.

His most cited work include:

  • Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover (1087 citations)
  • The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation. (618 citations)
  • A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner (334 citations)

What are the main themes of his work throughout his whole career to date?

Jeffrey L. Cleland spends much of his time researching Biochemistry, Pharmacology, Chromatography, In vivo and PLGA. His studies deal with areas such as Biophysics and Microsphere as well as Biochemistry. His Chromatography study integrates concerns from other disciplines, such as Sucrose, Polysorbate 20, Antibody and Isotonic.

Within one scientific family, Jeffrey L. Cleland focuses on topics pertaining to Endocrinology under In vivo, and may sometimes address concerns connected to Growth factor. His studies in PLGA integrate themes in fields like Adjuvant and Drug carrier, Drug delivery. The various areas that Jeffrey L. Cleland examines in his Drug carrier study include Liberation and Dosage form.

He most often published in these fields:

  • Biochemistry (25.69%)
  • Pharmacology (18.75%)
  • Chromatography (15.28%)

What were the highlights of his more recent work (between 2011-2021)?

  • Sunitinib (4.86%)
  • Pharmacology (18.75%)
  • Biomedical engineering (7.64%)

In recent papers he was focusing on the following fields of study:

Sunitinib, Pharmacology, Biomedical engineering, Dendrimer and In vivo are his primary areas of study. His study on Sunitinib also encompasses disciplines like

  • Macular degeneration which is related to area like Polymeric matrix, Solvent system, Corneal neovascularization, Controlled release and Cytotoxicity,
  • Choroidal neovascularization that intertwine with fields like Cancer research, Diabetic retinopathy, Tyrosine-kinase inhibitor and Leukostasis. The study incorporates disciplines such as VEGF receptors and Platelet-derived growth factor receptor in addition to Pharmacology.

His Biomedical engineering research focuses on Microparticle and how it relates to Extended release. His In vivo research incorporates themes from Hormone, Receptor, Potency and Pharmacodynamics. Biochemistry is frequently linked to Vascular endothelial growth factor in his study.

Between 2011 and 2021, his most popular works were:

  • A Novel Long-Acting Human Growth Hormone Fusion Protein (VRS-317): Enhanced In Vivo Potency and Half-Life (59 citations)
  • Scalable synthesis and validation of PAMAM dendrimer-N-acetyl cysteine conjugate for potential translation. (19 citations)
  • Sustained treatment of retinal vascular diseases with self-aggregating sunitinib microparticles (14 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Biochemistry
  • Organic chemistry

Jeffrey L. Cleland mainly focuses on Sunitinib, Choroid, Ophthalmology, In vivo and Macular degeneration. He interconnects Medical therapy, Pharmacokinetics, Biomedical engineering and Microparticle in the investigation of issues within In vivo. He has included themes like Endocrinology and Growth hormone deficiency in his Pharmacokinetics study.

His Macular degeneration research is multidisciplinary, relying on both Polymeric matrix, Solvent system, Corneal neovascularization, Controlled release and Cytotoxicity. He regularly ties together related areas like Pharmacology in his Cytotoxicity studies. His research combines Potency and Internal medicine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

John Street;Min Bao;Leo deGuzman;Stuart Bunting.
Proceedings of the National Academy of Sciences of the United States of America (2002)

1650 Citations

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

Cleland Jl;Powell Mf;Shire Sj.
Critical Reviews in Therapeutic Drug Carrier Systems (1993)

989 Citations

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody

Jeffrey L. Cleland;Xanthe Lam;Brent Kendrick;Janet Yang.
Journal of Pharmaceutical Sciences (2001)

497 Citations

A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

Volker Schellenberger;Chia-wei Wang;Nathan C Geething;Benjamin J Spink.
Nature Biotechnology (2009)

478 Citations

A month-long effect from a single injection of microencapsulated human growth hormone.

OluFunmi L. Johnson;Jeffrey L. Cleland;Hye Jung Lee;Margarita Charnis.
Nature Medicine (1996)

455 Citations

Stable Formulations of Recombinant Human Growth Hormone and Interferon-γ for Microencapsulation in Biodegradable Mircospheres

Jeffrey L. Cleland;Andrew J. S. Jones.
Pharmaceutical Research (1996)

397 Citations

Stabile isotonic lyophilized protein formulation

Shire Steven J;Andya James;Cleland Jeffrey L;Hsu Chung C.
(1996)

389 Citations

Antioxidants for Prevention of Methionine Oxidation in Recombinant Monoclonal Antibody HER2

Xanthe M. Lam;Janet Y. Yang;Jeffrey L. Cleland.
Journal of Pharmaceutical Sciences (1997)

362 Citations

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions

Narendra B. Bam;Jeffrey L. Cleland;Janet Yang;Mark C. Manning.
Journal of Pharmaceutical Sciences (1998)

360 Citations

The stabilization and encapsulation of human growth hormone into biodegradable microspheres

OluFunmi L. Johnson;Warren Jaworowicz;Jeffrey L. Cleland;Leonie Bailey.
Pharmaceutical Research (1997)

328 Citations

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