World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
78
Citations
33710
World Ranking
17822
National Ranking
8892

Overview

Steven D. Leach is affiliated with Dartmouth College in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with additional significant contributions in Medicine. The scientist's subfields of study include Oncology, Molecular Biology, Cancer Research, Immunology, and Surgery.

The scientist's work has focused on several main research topics: pancreatic and hepatic oncology research, cancer genomics and diagnostics, RNA modifications and cancer, cancer cells and metastasis, cancer-related molecular pathways, epigenetics and DNA methylation, as well as phagocytosis and immune regulation.

Notable recent publications by Steven D. Leach include:

  • ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity (2020, Nature)
  • A gene-environment-induced epigenetic program initiates tumorigenesis (2021, Nature)
  • Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer (2020, Cancer Cell)
  • Uncertain Beginnings: Acinar and Ductal Cell Plasticity in the Development of Pancreatic Cancer (2021, Cellular and Molecular Gastroenterology and Hepatology)
  • A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS (2023, Cell Stem Cell)

Steven D. Leach frequently publishes in several academic venues, with the following having notable numbers of their works:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • JNCI Cancer Spectrum
  • Cancer Cell

The scientist has collaborated often with several co-authors, including:

  • Rohit Chandwani
  • Luisa F. Escobar-Hoyos
  • Christine A. Iacobuzio-Donahue
  • Nicolas Lecomte
  • Gokce Askan

Best Publications

  • Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

    Siân Jones;Xiaosong Zhang;D. Williams Parsons;D. Williams Parsons;Jimmy Cheng Ho Lin

  • A draft map of the human proteome

    Min Sik Kim;Sneha M. Pinto;Derese Getnet;Raja Sekhar Nirujogi

  • EMT and Dissemination Precede Pancreatic Tumor Formation

    Andrew D. Rhim;Emily T. Mirek;Nicole M. Aiello;Anirban Maitra

  • Organoid Models of Human and Mouse Ductal Pancreatic Cancer

    Sylvia F. Boj;Chang Il Hwang;Chang Il Hwang;Lindsey A. Baker;Lindsey A. Baker;Iok In Christine Chio;Iok In Christine Chio

  • Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer.

    Vinod P. Balachandran;Marta Łuksza;Julia N. Zhao;Vladimir Makarov

  • Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

    Yoshiharu Miyamoto;Anirban Maitra;Bidyut Ghosh;Ulrich Zechner

  • Rationale for En Bloc Vein Resection in the Treatment of Pancreatic Adenocarcinoma Adherent to the Superior Mesenteric-Portal Vein Confluence

    George M. Fuhrman;Steven D. Leach;Charles A. Staley;James C. Cusack

  • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

    Nils Habbe;Guanglu Shi;Robert A. Meguid;Volker Fendrich;Volker Fendrich

  • Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing

    Diana Mandelker;Liying Zhang;Yelena Kemel;Yelena Kemel;Zsofia K. Stadler;Zsofia K. Stadler

  • Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia

    Florencia McAllister;Jennifer M. Bailey;Janivette Alsina;Christopher J. Nirschl

  • Epidemiology and risk factors

    Theresa Pluth Yeo;Ralph H. Hruban

  • Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates

    Anna L. Means;Ingrid M. Meszoely;Kazufumi Suzuki;Yoshiharu Miyamoto

  • Survival following pancreaticoduodenectomy with resection of the superior mesenteric–portal vein confluence for adenocarcinoma of the pancreatic head

    S. D. Leach;J. E. Lee;C. Charnsangavej;K. R. Cleary

  • Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway

    Oliver A. Kent;Raghu R. Chivukula;Michael Mullendore;Erik A. Wentzel

  • Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer.

    Andrew M. Lowy;Paul F. Mansfield;Steven D. Leach;Richard Pazdur

  • DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer

    Jennifer M. Bailey;Janivette Alsina;Zeshaan A. Rasheed;Florencia M. McAllister

  • Nonoperative management of primary colorectal cancer in patients with stage IV disease.

    Charles R. Scoggins;Ingrid M. Meszoely;Charles D. Blanke;R. Daniel Beauchamp

  • Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma

    D Delbeke;D M Rose;W C Chapman;C W Pinson

  • Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells

    Nijaguna B. Prasad;Andrew V. Biankin;Noriyoshi Fukushima;Anirban Maitra

  • Neoadjuvant chemoradiation for extrahepatic cholangiocarcinoma

    Kelly M. McMasters;Todd M. Tuttle;Steven D. Leach;Steven D. Leach;Tyvin Rich

Frequent Co-Authors

Irvin M. Modlin
Irvin M. Modlin Yale University
William C. Chapman
William C. Chapman Washington University in St. Louis
Charles D. Blanke
Charles D. Blanke Oregon Health & Science University
Jennifer A. Pietenpol
Jennifer A. Pietenpol Vanderbilt University Medical Center
Peter E. Schwartz
Peter E. Schwartz Yale University
Yu Shyr
Yu Shyr Vanderbilt University Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Considering a career in medicine doesn’t always mean becoming a doctor. Many students explore related fields through flexible online programs. For those seeking accessible education, affordable online nursing programs provide a strong gateway into healthcare. These programs offer cost-effective routes to begin or advance your nursing career.

Registered nurses aiming to boost credentials often choose affordable rn to bsn programs. Earning a Bachelor of Science in Nursing online can open the doors to more advanced roles and higher salaries. For those committed to leadership or academic positions, online nursing doctorate pathways are available for dedicated professionals who want to impact healthcare at a higher level.

If you have a non-nursing bachelor’s degree and dream of transitioning into nursing, consider non nursing bachelor's to msn online programs. These accelerated pathways allow you to quickly gain the skills necessary for advanced nursing roles, even without a previous nursing background.

Best Scientists Citing Steven D. Leach

Trending Scientists