Ronald T. Borchardt

Research.com Recognitions

• 1994 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• Stability of Protein Pharmaceuticals

  Mark C. Manning;Kamlesh Patel;Ronald T. Borchardt

  1936
  Citations

• Directed Drug Delivery

  Ronald T. Borchardt;Arnold J. Repta;Valentino J. Stella

  604
  Citations

• Enzymes involved in the bioconversion of ester-based prodrugs

  Bianca M. Liederer;Ronald T. Borchardt

  487
  Citations

• The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system.

  Manoj M. Nerurkar;Philip S. Burton;Ronald T. Borchardt

  448
  Citations

• Chemical Pathways of Peptide Degradation. II. Kinetics of Deamidation of an Asparaginyl Residue in a Model Hexapeptide

  Kamlesh Patel;Ronald T. Borchardt

  414
  Citations

• The use of cultured epithelial and endothelial cells for drug transport and metabolism studies.

  Kenneth L. Audus;Ronnda L. Bartel;Ismael J. Hidalgo;Ronald T. Borchardt

  400
  Citations

• Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond.

  Per Artursson;Ronald T. Borchardt

  391
  Citations

• Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

  Shihong Li;Christian Schöneich;Ronald T. Borchardt

  379
  Citations

• Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism.

  Kenneth L. Audus;Ronald T. Borchardt

  337
  Citations

• Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

  Aditya A. Wakankar;Ronald T. Borchardt

  334
  Citations

• Improvement of oral peptide bioavailability: Peptidomimetics and prodrug strategies

  Giovanni M. Pauletti;Giovanni M. Pauletti;Sanjeev Gangwar;Teruna J. Siahaan;Jeffrey Aubé

  316
  Citations

• A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P‐glycoprotein activity in vitro

  Erin D. Hugger;Barbara L. Novak;Philip S. Burton;Kenneth L. Audus

  308
  Citations

• Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa

  Fuxing Tang;Kazutoshi Horie;Ronald T. Borchardt

  304
  Citations

• S-adenosyl-L-homocysteine hydrolase as a target for antiviral chemotherapy

  Michael S. Wolfe;Ronald T. Borchardt

  289
  Citations

• Paracellular Diffusion in Caco-2 Cell Monolayers: Effect of Perturbation on the Transport of Hydrophilic Compounds That Vary in Charge and Size

  Gregory T. Knipp;Norman F.H. Ho;Craig L. Barsuhn;Ronald T. Borchardt

  280
  Citations

• Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier.

  Kenneth L. Audus;Ronald T. Borchardt

  276
  Citations

• Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells.

  R T Borchardt;B T Keller;U Patel-Thombre

  273
  Citations

• Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides.

  Elsbeth G. Chikhale;Ka-Yun Ng;Philip S. Burton;Ronald T. Borchardt

  272
  Citations

• Structural requirements for intestinal absorption of peptide drugs

  Giovanni M. Pauletti;Sanjeev Gangwar;Gregory T. Knipp;Manoj M. Nerurkar

  247
  Citations

• In vitro systems for studying intestinal drug absorption.

  Kathleen M. Hillgren;Akira Kato;Ronald T. Borchardt

  245
  Citations

• S-Adenosyl-L-methionine-dependent macromolecule methyltransferases: potential targets for the design of chemotherapeutic agents

  Ronald T. Borchardt

  241
  Citations