Michael S. Wolfe

Overview

Best Publications

• Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.

  Dominic M. Walsh;Igor Klyubin;Julia V. Fadeeva;William K. Cullen

  5554
  Citations

• A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

  Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig

  2785
  Citations

• Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

  Michael S. Wolfe;Michael S. Wolfe;Weiming Xia;Beth L. Ostaszewski;Thekla S. Diehl

  2531
  Citations

• c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

  Andrew P. Weng;John M. Millholland;Yumi Yashiro-Ohtani;Marie Laure Arcangeli

  1050
  Citations

• γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

  W. Taylor Kimberly;Matthew J. LaVoie;Beth L. Ostaszewski;Wenjuan Ye

  1049
  Citations

• The surface of articular cartilage contains a progenitor cell population.

  Gary P. Dowthwaite;Joanna C. Bishop;Samantha N. Redman;Ilyas M. Khan

  991
  Citations

• Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis

  Yoshiharu Miyamoto;Anirban Maitra;Bidyut Ghosh;Ulrich Zechner

  830
  Citations

• Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

  William P. Esler;W. Taylor Kimberly;Beth L. Ostaszewski;Thekla S. Diehl

  735
  Citations

• A Portrait of Alzheimer Secretases--New Features and Familiar Faces

  William P. Esler;Michael S. Wolfe

  713
  Citations

• Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

  Andrew P. Weng;Yunsun Nam;Michael S. Wolfe;Warren S. Pear

  532
  Citations

• Presenilins and γ-Secretase: Structure, Function, and Role in Alzheimer Disease

  Bart De Strooper;Takeshi Iwatsubo;Michael S. Wolfe

  523
  Citations

• Presenilin: Running with Scissors in the Membrane

  Dennis J. Selkoe;Michael S. Wolfe

  497
  Citations

• Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate

  William P. Esler;W. Taylor Kimberly;Beth L. Ostaszewski;Wenjuan Ye

  461
  Citations

• Intramembrane proteolysis: theme and variations.

  Michael S. Wolfe;Raphael Kopan

  449
  Citations

• Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease†

  Michael S. Wolfe;Weiming Xia;Chad L. Moore;Dartha D. Leatherwood

  413
  Citations

• Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway

  Yung-Feng Liao;Bo-Jeng Wang;Hui-Ting Cheng;Lan-Hsin Kuo

  398
  Citations

• The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

  W.Taylor Kimberly;Weiming Xia;Talat Rahmati;Michael S. Wolfe

  387
  Citations

• Substrate-targeting γ-secretase modulators

  Thomas L. Kukar;Thomas B. Ladd;Maralyssa A. Bann;Patrick C. Fraering;Patrick C. Fraering

  373
  Citations

• Cell Surface Presenilin-1 Participates in the γ-Secretase-like Proteolysis of Notch *

  William J. Ray;Min Yao;Jeff Mumm;Eric H. Schroeter

  360
  Citations

• A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

  Malcolm A. Leissring;M. Paul Murphy;Tonya R. Mead;Yama Akbari

  354
  Citations