What is he best known for?
The fields of study he is best known for:
His main research concerns Biochemistry, Presenilin, Amyloid precursor protein secretase, Cell biology and Notch signaling pathway.
In his study, Active site and Amyloid beta is strongly linked to Biophysics, which falls under the umbrella field of Biochemistry.
His Presenilin research incorporates elements of Membrane protein and Amyloid precursor protein.
His research in Amyloid precursor protein secretase intersects with topics in P3 peptide, Vesicle, Sphingolipid, Protease and Gamma secretase.
His Cell biology research is multidisciplinary, incorporating perspectives in Druggability, Proteolytic enzymes and Biotinylation.
Michael S. Wolfe has researched Notch signaling pathway in several fields, including Proteolysis, Endoplasmic reticulum and Transmembrane domain.
His most cited work include:
- Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. (3673 citations)
- A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. (1850 citations)
- Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. (1679 citations)
What are the main themes of his work throughout his whole career to date?
His primary scientific interests are in Biochemistry, Presenilin, Amyloid precursor protein secretase, Cell biology and Amyloid precursor protein.
His study in Presenilin is interdisciplinary in nature, drawing from both Protease, Membrane protein and Transmembrane protein.
His Amyloid precursor protein secretase research integrates issues from Biophysics, P3 peptide and Alpha secretase.
His study focuses on the intersection of Cell biology and fields such as γ secretase with connections in the field of Amyloid β.
His Amyloid precursor protein research is multidisciplinary, relying on both Cleavage, Stereochemistry, Aspartate protease, Peptidomimetic and Amyloid.
His research in APH-1 tackles topics such as PEN-2 which are related to areas like Gamma-secretase complex.
He most often published in these fields:
- Biochemistry (48.83%)
- Presenilin (42.97%)
- Amyloid precursor protein secretase (32.42%)
What were the highlights of his more recent work (between 2012-2021)?
- Biochemistry (48.83%)
- Presenilin (42.97%)
- Amyloid precursor protein secretase (32.42%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Biochemistry, Presenilin, Amyloid precursor protein secretase, Amyloid precursor protein and Cell biology.
His Biochemistry course of study focuses on Amyloid and Neuroscience, Gamma secretase and Apolipoprotein E.
His study of Nicastrin is a part of Presenilin.
His Amyloid precursor protein secretase study combines topics from a wide range of disciplines, such as P3 peptide, Proteases, APH-1, Endogeny and Structure–activity relationship.
Michael S. Wolfe has included themes like Amyloid beta and Membrane protein in his Amyloid precursor protein study.
His Cell biology research focuses on subjects like γ secretase, which are linked to Receptor, Intramembrane protease, Transcription and Pharmacology.
Between 2012 and 2021, his most popular works were:
- Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain (86 citations)
- Alternative polyadenylation and miR-34 family members regulate tau expression. (84 citations)
- Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ. (82 citations)
In his most recent research, the most cited papers focused on:
Michael S. Wolfe mainly investigates Transmembrane domain, Amyloid precursor protein secretase, Presenilin, Biochemistry and Cell biology.
His Transmembrane domain study incorporates themes from Nicastrin and Transmembrane protein.
In Amyloid precursor protein secretase, Michael S. Wolfe works on issues like P3 peptide, which are connected to Biochemistry of Alzheimer's disease.
The Presenilin study combines topics in areas such as Proteases and Amyloid precursor protein.
His study in Biochemistry focuses on Proteolysis and Carboxypeptidase.
His Cell biology research is multidisciplinary, incorporating elements of Genetics, Polyadenylation, Three prime untranslated region, Regulation of gene expression and Gene isoform.
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