World's Best Scientists 2026 revealed!
Takeshi Iwatsubo

Takeshi Iwatsubo

Award Badge
Biology and Biochemistry
Japan
2023

D-Index & Metrics

Medicine

D-Index
134
Citations
87195
World Ranking
2116
National Ranking
40

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Takeshi Iwatsubo is affiliated with the University of Tokyo in Japan. Their research primarily focuses on Alzheimer's disease and related neurodegenerative disorders, with a significant number of publications contributing to the fields of medicine, physiology, psychiatry and mental health, neurology, and molecular biology.

The scientist's work covers key topics including:

  • Alzheimer's disease research and treatments
  • Dementia and cognitive impairment research
  • Health systems, economic evaluations, quality of life
  • Cholinesterase and neurodegenerative diseases
  • Cellular transport and secretion
  • Functional brain connectivity studies
  • Parkinson's disease mechanisms and treatments

Takeshi Iwatsubo has published extensively, with notable recent papers including:

  • "Lecanemab in Early Alzheimer's Disease," 2022, New England Journal of Medicine
  • "The Amyloid-β Pathway in Alzheimer's Disease," 2021, Molecular Psychiatry
  • "Two Randomized Phase 3 Studies of Aducanumab in Early Alzheimer's Disease," 2022, The Journal of Prevention of Alzheimer s Disease
  • "World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia," 2020, Alzheimer s & Dementia
  • "Trial of Solanezumab in Preclinical Alzheimer's Disease," 2023, New England Journal of Medicine

The following are frequent co-authors in their publications:

  • Yoshiki Niimi
  • Kenichiro Sato
  • Atsushi Iwata
  • Ryoko Ihara
  • Takeshi Ikeuchi

Takeshi Iwatsubo's research output is regularly featured in established scientific venues, mainly:

  • Alzheimer s & Dementia
  • The Journal of Prevention of Alzheimer s Disease
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Alzheimer s Disease
  • Alzheimer s & Dementia Translational Research & Clinical Interventions

Their research contributions have helped advance understanding in Alzheimer's disease mechanisms, therapeutic developments, and dementia prevention strategies, with significant attention on the amyloid-beta pathway and clinical trial outcomes for disease-modifying agents.

Best Publications

  • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    Reisa A. Sperling;Paul S. Aisen;Laurel A. Beckett;David A. Bennett

  • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium

    I. G. McKeith;I. G. McKeith;D. W. Dickson;J. Lowe;M. Emre

  • |[alpha]|-Synuclein is phosphorylated in synucleinopathy lesions

    Hideo Fujiwara;Masato Hasegawa;Naoshi Dohmae;Akiko Kawashima

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

    Takeshi Iwatsubo;Asano Odaka;Nobuhiro Suzuki;Hidehiro Mizusawa

  • APP processing and synaptic function.

    Flavio Kamenetz;Taisuke Tomita;Helen Hsieh;Helen Hsieh;Guy Seabrook

  • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

    M. Baba;S. Nakajo;P.-H. Tu;T. Tomita

  • Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

    RS Rachelle S. Doody;RG Ronald G. Rg Thomas;Martin Farlow;Takeshi Iwatsubo

  • The Amyloid-β Pathway in Alzheimer's Disease.

    Harald Hampel;John Hardy;Kaj Blennow;Kaj Blennow;Christopher Chen

  • AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss.

    Helen Hsieh;Jannic Boehm;Chihiro Sato;Takeshi Iwatsubo

  • A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

    Rachelle S. Doody;Rema Raman;Martin Farlow;Takeshi Iwatsubo

  • Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

    Peter Davies;Judith Resnick;Burton Resnick;Sid Gilman

  • Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(pE), in senile plaques

    Takaomi C Saido;Takeshi Iwatsubo;David M.A Mann;Hiroyuki Shimada

  • Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein

    Pang-hsien Tu;James E. Galvin;James E. Galvin;Minami Baba;Benoit Giasson

  • Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein *

    Masayasu Okochi;Jochen Walter;Akihiko Koyama;Shigeo Nakajo

  • DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers

    C. F. Lippa;J. E. Duda;M. Grossman;H. I. Hurtig

  • Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

    K. Ito;T. Iwatsubo;S. Kanamitsu;K. Ueda

  • Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells.

    David G. Cook;Mark S. Forman;Jane C. Sung;Susan Leight

  • Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

    Carol F. Lippa;Hideo Fujiwara;David M.A. Mann;Benoit Giasson

  • Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup

    Reisa A. Sperling;Paul S. Aisen;Laurel A. Beckett;David A. Bennett

Frequent Co-Authors

Taisuke Tomita
Taisuke Tomita University of Tokyo
Masato Hasegawa
Masato Hasegawa Tokyo Metropolitan Institute of Medical Science
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
David M. A. Mann
David M. A. Mann University of Manchester
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Tohru Fukuyama
Tohru Fukuyama Nagoya University
Kenji Ishii
Kenji Ishii Nippon Medical School
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Ryozo Kuwano
Ryozo Kuwano Niigata University
Hiroyuki Arai
Hiroyuki Arai University of Tokyo

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Medicine in the USA opens up a range of online degrees and fast-track training options for healthcare careers. For aspiring nurses seeking an accelerated path, fast track medical programs allow you to become a Licensed Practical Nurse (LPN) in less time, combining online coursework with practical experience.

Registered nurses aiming for advanced roles may consider a 1 year dnp program online. These programs are designed to help working professionals earn a Doctor of Nursing Practice quickly and efficiently, often within a year.

Mental health remains a crucial component of healthcare. The fastest post master's pmhnp programs offer specialization for nurses looking to provide psychiatric and mental health services, bridging clinical expertise and patient-centered care.

For those interested in leadership and business roles within healthcare, a healthcare administration degree online provides vital skills in management, policy, and organizational strategy. These flexible options help support evolving healthcare careers and open up diverse pathways in the industry.

Best Scientists Citing Takeshi Iwatsubo

Trending Scientists

Recently Published Articles