Weiming Xia

Overview

Best Publications

• Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

  Michael S. Wolfe;Michael S. Wolfe;Weiming Xia;Beth L. Ostaszewski;Thekla S. Diehl

  2531
  Citations

• Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

  Martin Citron;David Westaway;Weiming Xia;George Carlson

  1800
  Citations

• Skeletal and CNS defects in Presenilin-1-deficient mice.

  Jie Shen;Roderick T Bronson;Dong Feng Chen;Weiming Xia

  1245
  Citations

• Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

  Li Bang Yang;Kristina Lindholm;Riqiang Yan;Martin Citron

  899
  Citations

• Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

  William P. Esler;W. Taylor Kimberly;Beth L. Ostaszewski;Thekla S. Diehl

  735
  Citations

• Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

  Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan

  627
  Citations

• The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

  Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou

  591
  Citations

• A detergent-insoluble membrane compartment contains Aβ in vivo

  Seung Jae Lee;Udaya Liyanage;Perry E. Bickel;Perry E. Bickel;Weiming Xia

  584
  Citations

• APP processing is regulated by cytoplasmic phosphorylation

  Ming Sum Lee;Shih Chu Kao;Cynthia A. Lemere;Weiming Xia

  522
  Citations

• Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

  Ruth G. Perez;Salvador Soriano;Jay D. Hayes;Beth Ostaszewski

  514
  Citations

• Peptidomimetic Probes and Molecular Modeling Suggest That Alzheimer's γ-Secretase Is an Intramembrane-Cleaving Aspartyl Protease†

  Michael S. Wolfe;Weiming Xia;Chad L. Moore;Dartha D. Leatherwood

  413
  Citations

• Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.

  Marcia B. Podlisny;Martin Citron;Patricia Amarante;Robin Sherrington

  413
  Citations

• Presenilin-mediated modulation of capacitative calcium entry.

  Andrew S. Yoo;Isaac Cheng;Sungkwon Chung;Tallessyn Z. Grenfell

  396
  Citations

• The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation

  W.Taylor Kimberly;Weiming Xia;Talat Rahmati;Michael S. Wolfe

  387
  Citations

• Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

  Weiming Xia;Jimin Zhang;Dora Kholodenko;Martin Citron

  381
  Citations

• Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

  Weiming Xia;Jimin Zhang;Ruth Perez;Edward H. Koo;Edward H. Koo

  353
  Citations

• The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation

  Zhongcong Xie;Yuanlin Dong;Uta Maeda;Robert D. Moir

  331
  Citations

• The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels

  Yuanlin Dong;Guohua Zhang;Guohua Zhang;Bin Zhang;Bin Zhang;Robert D. Moir

  329
  Citations

• A Substrate-Based Difluoro Ketone Selectively Inhibits Alzheimer's γ-Secretase Activity

  Michael S. Wolfe;Martin Citron;Thekla S. Diehl;Weiming Xia

  309
  Citations

• Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.

  Michael S. Wolfe;Joseph De Los Angeles;Joseph De Los Angeles;Duane D. Miller;Weiming Xia

  299
  Citations