D-Index & Metrics Best Publications

Weiming Xia

Houston Methodist
United States

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Biology and Biochemistry D-index 48 Citations 16,513 80 World Ranking 13885 National Ranking 5839

Overview

What is he best known for?

The fields of study Weiming Xia is best known for:

Gene
Enzyme
Amino acid

In his works, Weiming Xia conducts interdisciplinary research on Alzheimer's disease and Senile plaques. Weiming Xia conducted interdisciplinary study in his works that combined Senile plaques and Neurodegeneration. His Neurodegeneration study frequently links to related topics such as Disease. Disease is frequently linked to Amyloid beta in his study. His work often combines Amyloid beta and Alzheimer's disease studies. In his research, he undertakes multidisciplinary study on Biochemistry and Cell. In his works, he performs multidisciplinary study on Cell biology and Neuroscience. Weiming Xia carries out multidisciplinary research, doing studies in Neuroscience and Cell biology. Weiming Xia brings together Amyloid precursor protein and Peptide to produce work in his papers.

His most cited work include:

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity (1777 citations)
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice (1203 citations)
Skeletal and CNS Defects in Presenilin-1-Deficient Mice (886 citations)

What are the main themes of his work throughout his whole career to date

His Disease study frequently draws connections to adjacent fields such as Dementia. As part of his studies on Dementia, Weiming Xia often connects relevant areas like Disease. His study deals with a combination of Alzheimer's disease and Senile plaques. He performs integrative Senile plaques and Alzheimer's disease research in his work. He applies his multidisciplinary studies on Biochemistry and Molecular biology in his research. Weiming Xia merges Molecular biology with Genetics in his study. He integrates many fields in his works, including Genetics and Gene. Weiming Xia combines Gene and Presenilin in his studies. Weiming Xia integrates many fields in his works, including Presenilin and Enzyme.

Weiming Xia most often published in these fields:

Disease (75.78%)
Alzheimer's disease (64.06%)
Biochemistry (57.03%)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Michael S. Wolfe;Michael S. Wolfe;Weiming Xia;Beth L. Ostaszewski;Thekla S. Diehl.
Nature (1999)

2342 Citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron;David Westaway;Weiming Xia;George Carlson.
Nature Medicine (1997)

1751 Citations

Skeletal and CNS defects in Presenilin-1-deficient mice.

Jie Shen;Roderick T Bronson;Dong Feng Chen;Weiming Xia.
Cell (1997)

1189 Citations

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.

Li Bang Yang;Kristina Lindholm;Riqiang Yan;Martin Citron.
Nature Medicine (2003)

815 Citations

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

William P. Esler;W. Taylor Kimberly;Beth L. Ostaszewski;Thekla S. Diehl.
Nature Cell Biology (2000)

695 Citations

A detergent-insoluble membrane compartment contains Aβ in vivo

Seung Jae Lee;Udaya Liyanage;Perry E. Bickel;Perry E. Bickel;Weiming Xia.
Nature Medicine (1998)

569 Citations

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan.
Neuron (2006)

560 Citations

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou.
Nature (2006)

527 Citations

Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

Ruth G. Perez;Salvador Soriano;Jay D. Hayes;Beth Ostaszewski.
Journal of Biological Chemistry (1999)

496 Citations

APP processing is regulated by cytoplasmic phosphorylation

Ming Sum Lee;Shih Chu Kao;Cynthia A. Lemere;Weiming Xia.
Journal of Cell Biology (2003)

470 Citations

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Frequent Co-Authors

External Links

Personal Website for Weiming Xia