In his works, Weiming Xia conducts interdisciplinary research on Alzheimer's disease and Senile plaques. Weiming Xia conducted interdisciplinary study in his works that combined Senile plaques and Neurodegeneration. His Neurodegeneration study frequently links to related topics such as Disease. Disease is frequently linked to Amyloid beta in his study. His work often combines Amyloid beta and Alzheimer's disease studies. In his research, he undertakes multidisciplinary study on Biochemistry and Cell. In his works, he performs multidisciplinary study on Cell biology and Neuroscience. Weiming Xia carries out multidisciplinary research, doing studies in Neuroscience and Cell biology. Weiming Xia brings together Amyloid precursor protein and Peptide to produce work in his papers.
His Disease study frequently draws connections to adjacent fields such as Dementia. As part of his studies on Dementia, Weiming Xia often connects relevant areas like Disease. His study deals with a combination of Alzheimer's disease and Senile plaques. He performs integrative Senile plaques and Alzheimer's disease research in his work. He applies his multidisciplinary studies on Biochemistry and Molecular biology in his research. Weiming Xia merges Molecular biology with Genetics in his study. He integrates many fields in his works, including Genetics and Gene. Weiming Xia combines Gene and Presenilin in his studies. Weiming Xia integrates many fields in his works, including Presenilin and Enzyme.
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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Michael S. Wolfe;Michael S. Wolfe;Weiming Xia;Beth L. Ostaszewski;Thekla S. Diehl.
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
Martin Citron;David Westaway;Weiming Xia;George Carlson.
Nature Medicine (1997)
Skeletal and CNS defects in Presenilin-1-deficient mice.
Jie Shen;Roderick T Bronson;Dong Feng Chen;Weiming Xia.
Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease.
Li Bang Yang;Kristina Lindholm;Riqiang Yan;Martin Citron.
Nature Medicine (2003)
Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1
William P. Esler;W. Taylor Kimberly;Beth L. Ostaszewski;Thekla S. Diehl.
Nature Cell Biology (2000)
A detergent-insoluble membrane compartment contains Aβ in vivo
Seung Jae Lee;Udaya Liyanage;Perry E. Bickel;Perry E. Bickel;Weiming Xia.
Nature Medicine (1998)
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan.
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production
Lucia Pastorino;Anyang Sun;Anyang Sun;Pei-Jung Lu;Xiao Zhen Zhou.
Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42
Ruth G. Perez;Salvador Soriano;Jay D. Hayes;Beth Ostaszewski.
Journal of Biological Chemistry (1999)
APP processing is regulated by cytoplasmic phosphorylation
Ming Sum Lee;Shih Chu Kao;Cynthia A. Lemere;Weiming Xia.
Journal of Cell Biology (2003)
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