World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
10653
World Ranking
14485
National Ranking
6091

Overview

William A. Horton is affiliated with Shriners Hospitals for Children - Erie in the United States. Their research spans multiple topics primarily within medicine and biochemistry, genetics, and molecular biology. The focus areas of their work include connective tissue disorders research, bone fractures and treatments, orthopaedic implants and arthroplasty, bone health and osteoporosis research, protease and inhibitor mechanisms, gastroesophageal reflux and treatments, and pediatric hepatobiliary diseases and treatments.

The scientist's recent publications demonstrate a concentration on pediatric bone growth and biomarkers related to bone health. Notable papers include:

  • Pharmacokinetics and Exposure-Response of Vosoritide in Children with Achondroplasia (2021, Clinical Pharmacokinetics)
  • A quantitative serum biomarker of circulating collagen X effectively correlates with endochondral fracture healing (2020, Journal of Orthopaedic Research®)
  • Norms for Clinical Use of CXM, a Real-Time Marker of Height Velocity (2020, The Journal of Clinical Endocrinology & Metabolism)
  • Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children (2022, Maternal and Child Nutrition)
  • Correlation of collagen X biomarker (CXM) with peak height velocity and radiographic measures of growth in idiopathic scoliosis (2021, Spine Deformity)

Frequent coauthors collaborating with William A. Horton include Ryan F. Coghlan, Brian Johnstone, Robert C. Olney, Ricki Carroll, and Angela L. Duker. These collaborations suggest an interdisciplinary approach involving clinical endocrinology, orthopaedic research, and pediatric studies.

William A. Horton's publications are often featured in specialized journals such as Clinical Pharmacokinetics, Journal of Orthopaedic Research®, The Journal of Clinical Endocrinology & Metabolism, Maternal and Child Nutrition, and Spine Deformity. This distribution reflects a research profile strongly connected with clinical applications in bone health, growth biomarkers, and pediatric care.

The scientist's work is situated within broader fields of study:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

And more specific subfields:

  • Surgery
  • Genetics
  • Molecular Biology
  • Epidemiology
  • Nephrology

Best Publications

  • International Nosology of Heritable Disorders of Connective Tissue, Berlin, 1986.

    P. Beighton;A. de Paepe;D. Danks;G. Finidori

  • Achondroplasia is defined by recurrent G380R mutations of FGFR3.

    G A Bellus;T W Hefferon;R I Ortiz de Luna;J T Hecht

  • Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)

    Jung Ahn;Hermann-Josef Lüdecke;Steffi Lindow;William A. Horton

  • A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia.

    Gary A. Bellus;Iain McIntosh;Iain McIntosh;E. Anne Smith;Arthur S. Aylsworth

  • Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-β signaling

    Lara Longobardi;Lynda O'Rear;Srikanth Aakula;Brian Johnstone

  • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism.

    Wu Chou S. Su;Motoo Kitagawa;Ninrong Xue;Bing Xie

  • STANDARD GROWTH CURVES FOR ACHONDROPLASIA

    William A. Horton;Jerome I. Rotter;David L. Rimoin;Charles I. Scott

  • Expression of the human chondrocyte phenotype in vitro.

    Amy Lynn Aulthouse;Michael Beck;Edward Griffey;Julie Sanford

  • Crude subcellular fractionation of cultured mammalian cell lines

    Paul Holden;Paul Holden;William A Horton;William A Horton

  • Xeroderma pigmentosum and Cockayne syndrome: overlapping clinical and biochemical phenotypes.

    G. A. Greenhaw;Adelaide A Hebert;M. E. Duke-Woodside;Ian J Butler

  • Mortality in achondroplasia.

    Jacqueline T Hecht;C. A. Francomano;W. A. Horton;J. F. Annegers

  • Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.

    S Garofalo;E Vuorio;M Metsaranta;R Rosati

  • International nomenclature and classification of the osteochondrodysplasias (1997) international working group on constitutional diseases of bone

    David L. Rimoin;Glair A. Francomano;Andres Giedion;Christine Hall

  • Normal long bone growth and development in type X collagen-null mice.

    Rita Rosati;Gerald S.B. Horan;Gerald J. Pinero;Silvio Garofalo

  • The Fate of Cartilage Oligomeric Matrix Protein Is Determined by the Cell Type in the Case of a Novel Mutation in Pseudoachondroplasia

    B. Kerry Maddox;B. Kerry Maddox;Douglas R. Keene;Douglas R. Keene;Lynn Y. Sakai;Lynn Y. Sakai;Noé L. Charbonneau

  • Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia

    Jay Y. Cho;Changsheng Guo;Monica Torello;Gregory P. Lunstrum

  • Growth of the foramen magnum in achondroplasia.

    Jacqueline T. Hecht;William A. Horton;Cheryl S. Reid;Reed E. Pyeritz

  • Skeletal dysplasia and defective chondrocyte differentiation by targeted overexpression of fibroblast growth factor 9 in transgenic mice.

    Silvio Garofalo;Silvio Garofalo;Silvio Garofalo;Michal Kliger-Spatz;Jeremy L. Cooke;Orit Wolstin

  • Computerized tomography of the foramen magnum: achondroplastic values compared to normal standards.

    Jacqueline T Hecht;F. W. Nelson;Ian J Butler;W. A. Horton

  • Chondrocyte Differentiation in a Rat Mesenchymal Cell Line

    Gregory P. Lunstrum;Douglas R. Keene;Nicole B. Weksler;Yoon Jae Cho

Frequent Co-Authors

Jacqueline T. Hecht
Jacqueline T. Hecht The University of Texas Health Science Center at Houston
Douglas R. Keene
Douglas R. Keene Shriners Hospitals for Children - Portland
David L. Rimoin
David L. Rimoin Cedars-Sinai Medical Center
Judith G. Hall
Judith G. Hall University of British Columbia
Hans Peter Bächinger
Hans Peter Bächinger Oregon Health & Science University
Brendan Lee
Brendan Lee Baylor College of Medicine
Lynn Y. Sakai
Lynn Y. Sakai Oregon Health & Science University
Ralph S. Lachman
Ralph S. Lachman University of California, Los Angeles
Clair A. Francomano
Clair A. Francomano Indiana University
John M. Opitz
John M. Opitz University of Utah

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