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Peter M. T. Deen

Peter M. T. Deen

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
15100
World Ranking
8704
National Ranking
228

Overview

Peter M. T. Deen is affiliated with Radboud University in the Netherlands. Their research spans across multiple fields within medicine and the biological sciences, focusing notably on molecular biology and cancer research. The subfields of their work include molecular biology, cancer research, infectious diseases, surgery, and neurology.

The main topics covered in their research involve adrenal and paraganglionic tumors, cancer, hypoxia, and metabolism. They also investigate retinal development and disorders, retinal diseases and treatments, electrolyte and hormonal disorders, as well as SARS-CoV-2 and COVID-19 related research. Additionally, they have done work related to animal testing and alternatives.

Peter M. T. Deen has frequently published in several scientific venues. These include:

  • Current Biology
  • Frontiers in Endocrinology
  • Communications Biology
  • Experimental Eye Research
  • Endocrine Related Cancer

Their recent papers exemplify the diversity of their interests and contributions. Notable publications include:

  • How the COVID-19 pandemic highlights the necessity of animal research (2020, Current Biology)
  • Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas (2021, Frontiers in Endocrinology)
  • Differential day-night expression of tight junction components in murine retinal pigment epithelium (2020, Experimental Eye Research)
  • Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics (2020, Endocrine Related Cancer)
  • MicroRNA-132 regulates salt-dependent steady-state renin levels in mice (2020, Communications Biology)

They collaborate regularly with several coauthors, indicating ongoing research partnerships. Frequent collaborators include:

  • Elja Louer
  • Claudia Carmone
  • Anneke I. den Hollander
  • Lisa Genzel
  • Roger A.H. Adan

Best Publications

  • mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

    Shih-Chin Cheng;Jessica Quintin;Robert A. Cramer;Kelly M. Shepardson

  • Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.

    P. M. T. Deen;M. A. J. Verdijk;N. V. A. M. Knoers;B. Wieringa

  • Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.

    Michelle Boone;Peter M. T. Deen

  • An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex.

    S. M. Mulders;D. G. Bichet;J. P. L. Rijss;E.-J. Kamsteeg

  • Collecting Duct Principal Cell Transport Processes and Their Regulation

    David Pearce;Rama Soundararajan;Christiane Trimpert;Ossama B. Kashlan

  • Water channels encoded by mutant aquaporin-2 genes in nephrogenic diabetes insipidus are impaired in their cellular routing.

    P.M.T. Deen;H.J.E. Croes;R.A.M.H. van Aubel;L.A. Ginsel

  • A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders.

    Jocelien Olivier;M G C Van Der Hart;R P L Van Swelm;P J Dederen

  • Water Channel Properties of Major Intrinsic Protein of Lens

    S.M. Mulders;G.M. Preston;P.M.T. Deen;W.B. Guggino

  • The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel.

    Bas W.M. van Balkom;Paul J.M. Savelkoul;Daniel Markovich;Erik Hofman

  • Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel

    Erik-Jan Kamsteeg;Giel Hendriks;Michelle Boone;Irene B. M. Konings

  • An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus.

    Erik Jan Kamsteeg;Thera A.M. Wormhoudt;Johan P.L. Rijss;Carel H. Van Os

  • The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.

    Mingqi Lu;M.D. Lee;B.L. Smith;J.S. Jung

  • The Succinate Receptor as a Novel Therapeutic Target for Oxidative and Metabolic Stress-Related Conditions

    Ana Carolina Ariza;Peter Meinardus T. Deen;Joris Hubertus Robben

  • Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus

    Joris H. Robben;Nine V. A. M. Knoers;Peter M. T. Deen

  • New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels.

    S.M. Mulders;N.V.A.M. Knoers;A.F. van Lieburg;L.A.H. Monnens

  • The Subcellular Localization of an Aquaporin-2 Tetramer Depends on the Stoichiometry of Phosphorylated and Nonphosphorylated Monomers

    E.J. Kamsteeg;I. Heijnen;C.H. van Os;P.M.T. Deen

  • Heteroligomerization of an Aquaporin-2 mutant with wild-type Aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus

    Nannette Marr;Daniel G Bichet;Michele Lonergan;Marie-Francoise Arthus

  • Glycosylation Is Important for Cell Surface Expression of the Water Channel Aquaporin-2 but Is Not Essential for Tetramerization in the Endoplasmic Reticulum

    Giel Hendriks;Marco Koudijs;Bas W.M. van Balkom;Viola Oorschot

  • Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action.

    Frank J.M. Detmers;Bert L. de Groot;E. Matthias Müller;Andrew Hinton

  • Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport.

    P. M. T. Deen;J. P. L. Rijss;S. M. Mulders;R. J. Errington

Frequent Co-Authors

C.H. van Os
C.H. van Os Radboud University
Nine V.A.M. Knoers
Nine V.A.M. Knoers University Medical Center Groningen
Peter van der Sluijs
Peter van der Sluijs Utrecht University
Daniel G. Bichet
Daniel G. Bichet University of Montreal
Olivier Devuyst
Olivier Devuyst University of Zurich
Jack F.M. Wetzels
Jack F.M. Wetzels Radboud University
Mihai G. Netea
Mihai G. Netea Radboud University
Ron A. Wevers
Ron A. Wevers Radboud University
Anneke I. den Hollander
Anneke I. den Hollander Radboud University
Arjan Blokland
Arjan Blokland Maastricht University

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