Edward H. Koo

Research.com Recognitions

• 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Best Publications

• Amyloid β-peptide is produced by cultured cells during normal metabolism

  C Haass;M G Schlossmacher;M G Schlossmacher;A Y Hung;C Vigo-Pelfrey

  2625
  Citations

• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

  Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  2280
  Citations

• A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

  Sascha Weggen;Jason L. Eriksen;Pritam Das;Sarah A. Sagi

  1863
  Citations

• Amyloid Precursor Protein Trafficking, Processing, and Function

  Gopal Thinakaran;Edward H. Koo

  1447
  Citations

• Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

  Mason A. Israel;Shauna H. Yuan;Cedric Bardy;Sol M. Reyna

  1347
  Citations

• Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing.

  S. S. Sisodia;E. H. Koo;K. Beyreuther;A. Unterbeck

  1333
  Citations

• Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

  Christian Haass;Edward H. Koo;Angela Mellon;Albert Y. Hung

  1313
  Citations

• Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

  Alan H Nagahara;David A Merrill;Giovanni Coppola;Shingo Tsukada

  1198
  Citations

• Amyloid diseases: abnormal protein aggregation in neurodegeneration.

  Edward H. Koo;Peter T. Lansbury;Jeffery W. Kelly

  1006
  Citations

• Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

  Edward H. Koo;Sangram S. Sisodia;David R. Archer;Lee J. Martin

  939
  Citations

• NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

  Jason L. Eriksen;Sarah A. Sagi;Tawnya E. Smith;Sascha Weggen

  863
  Citations

• Exchange of N-CoR Corepressor and Tip60 Coactivator Complexes Links Gene Expression by NF-κB and β-Amyloid Precursor Protein

  Sung Hee Baek;Kenneth A. Ohgi;David W. Rose;Edward H. Koo

  739
  Citations

• The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

  Lemere Ca;Lopera F;Kosik Ks;Lendon Cl

  661
  Citations

• Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture.

  Marcia B. Podlisny;Beth L. Ostaszewski;Sharon L. Squazzo;Edward H. Koo

  543
  Citations

• A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor

  Daniel C. Lu;Daniel C. Lu;Shahrooz Rabizadeh;Shahrooz Rabizadeh;Sreeganga Chandra;Rana F. Shayya

  521
  Citations

• Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42

  Ruth G. Perez;Salvador Soriano;Jay D. Hayes;Beth Ostaszewski

  514
  Citations

• The amyloid precursor protein: beyond amyloid.

  Hui Zheng;Hui Zheng;Edward H Koo;Edward H Koo

  508
  Citations

• Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

  David E. Kang;Claus U. Pietrzik;Larry Baum;Nathalie Chevallier

  503
  Citations

• Anti-Aβ Therapeutics in Alzheimer's Disease: The Need for a Paradigm Shift

  Todd E. Golde;Lon S. Schneider;Edward H. Koo

  466
  Citations

• Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.

  Marcia B. Podlisny;Martin Citron;Patricia Amarante;Robin Sherrington

  413
  Citations