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John K. Fazakerley

John K. Fazakerley

D-Index & Metrics

Immunology

D-Index
51
Citations
6753
World Ranking
4177
National Ranking
175

Overview

John K. Fazakerley is affiliated with the University of Melbourne in Australia. Their research primarily focuses on medicine, with significant contributions to public health, environmental and occupational health, infectious diseases, immunology, insect science, and epidemiology.

The scientist's work addresses several main topics, including:

  • Mosquito-borne diseases and control
  • Viral infections and vectors
  • Interferon and immune responses
  • Insect symbiosis and bacterial influences
  • Influenza virus research studies
  • CRISPR and genetic engineering
  • Cytokine signaling pathways and interactions

John K. Fazakerley has published research in multiple scientific venues, notably:

  • Viruses
  • Immunology and Cell Biology
  • iScience
  • Nature Communications
  • Journal of Innate Immunity

Some of their recent papers include:

  • "Superinfection Exclusion in Mosquitoes and Its Potential as an Arbovirus Control Strategy" (2020), published in Viruses
  • "Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection" (2022), published in Viruses
  • "Mosquito transgenerational antiviral immunity is mediated by vertical transfer of virus DNA sequences and RNAi" (2023), published in iScience
  • "Prior infection with unrelated neurotropic virus exacerbates influenza disease and impairs lung T cell responses" (2024), published in Nature Communications
  • "Immature Brain Cortical Neurons Have Low Transcriptional Competence to Activate Antiviral Defences and Control RNA Virus Infections" (2022), published in Journal of Innate Immunity

Frequent collaborators include:

  • Isabelle J. H. Foo
  • Łukasz Kedzierski
  • Katherine Kedzierska
  • Julio Rodriguez-Andres
  • Hayley A. McQuilten

Best Publications

  • Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis

    Anne Bridgen;Friedemann Weber;John K. Fazakerley;Richard M. Elliott

  • Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/Beta Interferon

    Friedemann Weber;Anne Bridgen;John K. Fazakerley;Hein Streitenfeld

  • Knockdown of piRNA pathway proteins results in enhanced Semliki Forest virus production in mosquito cells

    Esther Schnettler;Esther Schnettler;Claire L. Donald;Claire L. Donald;Stacey Human;Stacey Human;Mick Watson

  • Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68.

    N P Sunil-Chandra;J Arno;John Fazakerley;Anthony Nash

  • Host Inflammatory Response to Mosquito Bites Enhances the Severity of Arbovirus Infection

    Marieke Pingen;Steven R. Bryden;Steven R. Bryden;Emilie Pondeville;Esther Schnettler

  • Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL/6 mice.

    David Hallengärd;Maria Kakoulidou;Aleksei Lulla;Beate M. Kümmerer

  • Flavivirus Receptors: Diversity, Identity, and Cell Entry.

    Mathilde Laureti;Divya Narayanan;Julio Rodriguez-Andres;John K Fazakerley

  • Antiviral RNA Interference Responses Induced by Semliki Forest Virus Infection of Mosquito Cells: Characterization, Origin, and Frequency-Dependent Functions of Virus-Derived Small Interfering RNAs

    Ricky W. C. Siu;Rennos Fragkoudis;Peter Simmonds;Claire L. Donald

  • Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses

    Esther Schnettler;Hana Tykalová;Mick Watson;Mayuri Sharma

  • Advances in dissecting mosquito innate immune responses to arbovirus infection.

    Rennos Fragkoudis;Ghassem Attarzadeh-Yazdi;Anthony A. Nash;John K. Fazakerley

  • Replication of the A7(74) strain of Semliki Forest virus is restricted in neurons

    John K. Fazakerley;Snehlata Pathak;Martina Scallan;Sandra Amor

  • In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression.

    Clive S. McKimmie;John K. Fazakerley

  • Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus.

    Julio Rodriguez-Andres;Julio Rodriguez-Andres;Seema Rani;Margus Varjak;Margo E. Chase-Topping

  • Semliki Forest Virus Nonstructural Protein 2 Is Involved in Suppression of the Type I Interferon Response

    Lucy Breakwell;Pia Dosenovic;Pia Dosenovic;Gunilla B. Karlsson Hedestam;Gunilla B. Karlsson Hedestam;Mauro D'Amato

  • The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system.

    John K. Fazakerley;Suezanne E. Parker;Floyd Bloom;Michael J. Buchmeier

  • Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis

    Sandra Amor;Martina F. Scallan;Margaret M. Morris;Heather Dyson

  • Semliki Forest virus strongly reduces mosquito host defence signaling

    Rennos Fragkoudis;Y. Chi;R. W. Siu;Gerald Barry

  • A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication

    Samantha J Griffiths;Manfred Koegl;Chris Boutell;Helen L Zenner

  • Viruses selectively upregulate Toll-like receptors in the central nervous system

    Clive S. McKimmie;Nicholas Johnson;Anthony R. Fooks;John K. Fazakerley

  • A single amino acid change in the nuclear localization sequence of the nsP2 protein affects the neurovirulence of Semliki Forest virus.

    John K. Fazakerley;Amanda Boyd;Marja L. Mikkola;Leevi Kääriäinen

  • Insertion of EGFP into the replicase gene of Semliki Forest virus results in a novel, genetically stable marker virus

    Nele Tamberg;Valeria Lulla;Rennos Fragkoudis;Aleksei Lulla

Frequent Co-Authors

Alain Kohl
Alain Kohl University of Glasgow
Andres Merits
Andres Merits University of Tartu
Anthony Nash
Anthony Nash University of Edinburgh
James W. Ironside
James W. Ironside University of Edinburgh
Anthony R. Fooks
Anthony R. Fooks St George's, University of London
Mark Head
Mark Head University of Edinburgh
Friedemann Weber
Friedemann Weber University of Giessen
Richard M. Elliott
Richard M. Elliott University of Glasgow
Peter Liljeström
Peter Liljeström Karolinska Institute
Nicholas Johnson
Nicholas Johnson Animal and Plant Health Agency

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