World's Best Scientists 2026 revealed!

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Microbiology

D-Index
71
Citations
13852
World Ranking
1889
National Ranking
799

Overview

Samuel H. Speck is affiliated with Emory University in the United States. Their research primarily focuses on medical science, with an emphasis on epidemiology, oncology, pathology and forensic medicine, public health, environmental and occupational health, and infectious diseases.

The scientist's work encompasses a range of topics including cytomegalovirus and herpesvirus research, herpesvirus infections and treatments, viral-associated cancers and disorders, Whipple's disease and interleukins, mosquito-borne diseases and control, viral infections and vectors, and the complement system in diseases.

Recent publications by Samuel H. Speck include the following:

  • Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation (2020, PLoS Pathogens)
  • Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo (2022, Pathogens)
  • Murine gammaherpesvirus infection is skewed toward Igλ+ B cells expressing a specific heavy chain V-segment (2020, PLoS Pathogens)
  • Acute Epstein Barr Virus is a risk factor for severe malaria in infants under 24 months (2025, bioRxiv (Cold Spring Harbor Laboratory))

The most frequent publication venues for their research include:

  • PLoS Pathogens
  • Pathogens
  • bioRxiv (Cold Spring Harbor Laboratory)

Collaborations with other researchers are a notable aspect of Samuel H. Speck's work. Frequent co-authors include Christopher M. Collins, Johannes Schwerk, Lucas Kemper, Kendra A. Bussey, and Stefan Lienenklaus.

Best Publications

  • E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

    Erik K. Flemington;Samuel H. Speck;William G. Kaelin

  • Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells.

    Karen E. Weck;Susanne S. Kim;Herbert W. Virgin;Samuel H. Speck

  • Viral Latency and Its Regulation: Lessons from the γ-Herpesviruses

    Samuel H. Speck;Don Ganem

  • Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

    Chun Kung;Jeanette T. Pingel;Markku Heikinheimo;Markku Heikinheimo;Timo Klemola

  • Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1.

    E Flemington;S H Speck

  • RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

    William J. Kaiser;Lisa P. Daley-Bauer;Roshan J. Thapa;Pratyusha Mandal

  • Pathogenesis and host control of gammaherpesviruses: lessons from the mouse.

    Erik Barton;Pratyusha Mandal;Samuel H Speck

  • Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease.

    Karen E. Weck;Albert J. Dal Canto;James D. Gould;Andrew K. O'Guin

  • Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.

    Maximilian Woisetschlaeger;Chandra N. Yandava;Lisa A. Furmanski;Jack L. Strominger

  • B cells regulate murine gammaherpesvirus 68 latency.

    Karen E. Weck;Susanne S. Kim;Herbert W. Virgin;Samuel H. Speck

  • Rapid Demethylation of the IFN-γ Gene Occurs in Memory but Not Naive CD8 T Cells

    Ellen N. Kersh;David R. Fitzpatrick;Kaja Murali-Krishna;John Shires

  • Identification of a Gammaherpesvirus Selective Chemokine Binding Protein That Inhibits Chemokine Action

    Victor van Berkel;John Barrett;H. Lee Tiffany;Daved H. Fremont

  • Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter

    T.A. Reese;B.S. Wakeman;H.S. Choi;M.M. Hufford

  • Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1.

    E Flemington;S H Speck

  • Redefining the Epstein-Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines.

    Brian C. Schaefer;Jack L. Strominger;Samuel H. Speck

  • Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice

    Herbert W. Virgin;Rachel M. Presti;Xi-Yang Li;Carl Liu

  • Definition of cytochrome c binding domains by chemical modification: Kinetics of reaction with beef mitochondrial reductase and functional organization of the respiratory chain

    Samuel H. Speck;Shelagh Ferguson-Miller;Neil Osheroff;E. Margoliash

  • Long-term latent murine Gammaherpesvirus 68 infection is preferentially found within the surface immunoglobulin D-negative subset of splenic B cells in vivo.

    David O. Willer;Samuel H. Speck

  • Cyclosporin A-sensitive induction of the Epstein-Barr virus lytic switch is mediated via a novel pathway involving a MEF2 family member

    Shaofan Liu;Pingfan Liu;Ana Borras;Talal Chatila

  • Influence of Burkitt's lymphoma and primary B cells on latent gene expression by the nonimmortalizing P3J-HR-1 strain of Epstein-Barr virus.

    C Rooney;J G Howe;S H Speck;G Miller

  • The gammaherpesvirus 68 latency-associated nuclear antigen homolog is critical for the establishment of splenic latency.

    Nathaniel J. Moorman;David O. Willer;Samuel H. Speck

  • Mutually exclusive use of viral promoters in Epstein-Barr virus latently infected lymphocytes.

    Maximilian Woisetschlaeger;Jack L. Strominger;Samuel H. Speck

  • Identification of the in vivo role of a viral bcl-2.

    Shivaprakash Gangappa;Linda F. van Dyk;Travis J. Jewett;Samuel H. Speck

  • Molecular cloning of complementary DNAs encoding the heavy chain of the human 4F2 cell-surface antigen: a type II membrane glycoprotein involved in normal and neoplastic cell growth

    Elizabeth Quackenbush;Martha Clabby;Keith M. Gottesdiener;James Barbosa

  • Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter

    T.A. Reese;B.S. Wakeman;H.S. Choi;M.M. Hufford

Frequent Co-Authors

Jack L. Strominger
Jack L. Strominger Harvard University
Neil Osheroff
Neil Osheroff Vanderbilt University
Erik K. Flemington
Erik K. Flemington Tulane University
Anne E. Goldfeld
Anne E. Goldfeld Boston Children's Hospital
Jeremy M. Boss
Jeremy M. Boss Emory University
Christian P. Larsen
Christian P. Larsen Emory University
Mauricio Rojas
Mauricio Rojas University of Pittsburgh
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
Edward S. Mocarski
Edward S. Mocarski Emory University

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