World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
91
Citations
25652
World Ranking
2359
National Ranking
1257

Research.com Recognitions

  • 2018 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Neil Osheroff is affiliated with Vanderbilt University in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with additional contributions in medicine. Major subfields of study include molecular biology, organic chemistry, oncology, toxicology, and molecular medicine.

The scientist's work focuses on several key scientific topics:

  • Cancer therapeutics and mechanisms
  • Bioactive compounds and antitumor agents
  • Neutropenia and cancer infections
  • Synthesis and biological activity
  • DNA and nucleic acid chemistry
  • Antibiotic resistance in bacteria
  • DNA repair mechanisms

Among frequent coauthors are Jo Ann W. Byl, Jessica A. Collins, Alexandria A. Oviatt, Keir C. Neuman, and Jeffrey Jian.

Osheroff's research is regularly published in notable scientific journals, including:

  • ACS Infectious Diseases
  • Methods in Molecular Biology
  • International Journal of Molecular Sciences
  • Medical Science Educator
  • Journal of Biological Chemistry

Key recent papers include:

  • "Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors" (2021) published in Biochemistry
  • "Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance" (2024) published in ACS Infectious Diseases
  • "Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms" (2022) published in The EMBO Journal
  • "Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity" (2022) published in Journal of Medicinal Chemistry
  • "Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae: Actions of Ciprofloxacin against Gyrase and Topoisomerase IV" (2024) published in ACS Infectious Diseases

Neil Osheroff was awarded the status of Fellow of the American Association for the Advancement of Science (AAAS) in 2018.

Best Publications

  • Mechanism of quinolone action and resistance.

    Katie J. Aldred;Robert J. Kerns;Neil Osheroff

  • Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme.

    D A Burden;N Osheroff

  • Topoisomerase poisons: harnessing the dark side of enzyme mechanism.

    Stacie J. Froelich-Ammon;Neil Osheroff

  • In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction

    Miguel Berrios;Neil Osheroff;Paul A. Fisher

  • Etoposide, topoisomerase II and cancer.

    E L Baldwin;N Osheroff

  • The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

    Joseph E. Deweese;Neil Osheroff

  • Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice.

    John M. Fortune;Neil Osheroff

  • DNA Topoisomerase II, Genotoxicity, and Cancer

    A. Kathleen McClendon;Neil Osheroff

  • DNA topoisomerase II from Drosophila melanogaster. Relaxation of supercoiled DNA.

    N Osheroff;E R Shelton;D L Brutlag

  • Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

    Neil Osheroff

  • DNA Topoisomerase II in Therapy-Related Acute Promyelocytic Leukemia

    Anita R. Mistry;Carolyn A. Felix;Ryan J. Whitmarsh;Annabel Mason

  • Catalytic function of DNA topoisomerase II.

    Neil Osheroff;E. Lynn Zechiedrich;Kevin C. Gale

  • Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

    Neil Osheroff

  • Merbarone Inhibits the Catalytic Activity of Human Topoisomerase IIα by Blocking DNA Cleavage

    John M. Fortune;Neil Osheroff

  • EUKARYOTIC TOPOISOMERASES RECOGNIZE NUCLEIC ACID TOPOLOGY BY PREFERENTIALLY INTERACTING WITH DNA CROSSOVERS

    E. L. Zechiedrich;N. Osheroff

  • When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs.

    Anita Corbett;Niel Osheroff

  • Phosphorylation of DNA topoisomerase II by casein kinase II: modulation of eukaryotic topoisomerase II activity in vitro.

    Pat Ackerman;Claiborne V. C. Glover;Neil Osheroff

  • Eukaryotic topoisomerase II. Characterization of enzyme turnover.

    N Osheroff

  • Type II topoisomerases as targets for quinolone antibacterials: turning Dr. Jekyll into Mr. Hyde.

    Virginia E. Anderson;Neil Osheroff

  • Topoisomerase II and leukemia

    MaryJean Pendleton;R. Hunter Lindsey;Carolyn A. Felix;David Grimwade

Frequent Co-Authors

Carolyn A. Felix
Carolyn A. Felix Children's Hospital of Philadelphia
Anita H. Corbett
Anita H. Corbett Emory University
John L. Nitiss
John L. Nitiss University of Illinois at Chicago
Charles L. Turnbough
Charles L. Turnbough University of Alabama at Birmingham
James M. Berger
James M. Berger Johns Hopkins University
David Grimwade
David Grimwade King's College London
Samuel H. Speck
Samuel H. Speck Emory University
Eric F. Rappaport
Eric F. Rappaport Children's Hospital of Philadelphia
James L. Van Etten
James L. Van Etten University of Nebraska–Lincoln
Ellen Solomon
Ellen Solomon King's College London

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