Leonard A. Zwelling

Overview

Best Publications

• DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity.

  Leonard A. Zwelling;Tom Anderson;Kurt W. Kohn

  584
  Citations

• Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin.

  Leonard A. Zwelling;Stephen Michaels;Leonard C. Erickson;Richard S. Ungerleider

  559
  Citations

• Cancer Drugs in the United States: Justum Pretium—The Just Price

  Hagop M. Kantarjian;Tito Fojo;Michael Mathisen;Leonard A. Zwelling

  387
  Citations

• The clinical features of hepatic angiosarcoma: a report of four cases and a review of the English literature.

  Gershon Y. Locker;James H. Doroshow;Leonard A. Zwelling;Bruce A. Chabner

  328
  Citations

• DNA Cross-Linking as an Indicator of Sensitivity and Resistance of Mouse L1210 Leukemia to cis-Diamminedichloroplatinum(II) and l-Phenylalanine Mustard

  Leonard A. Zwelling;Stephen Michaels;Howard Schwartz;Patricia P. Dobson

  313
  Citations

• Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells.

  Yves Pommier;Leonard A. Zwelling;Chien Song Kao-Shan;Jacqueline Whang-Peng

  252
  Citations

• Characterization of an amsacrine-resistant line of human leukemia cells: evidence for a drug-resistant form of topoisomerase II

  L. A. Zwelling;M. Hinds;D. Chan;J. Mayes

  250
  Citations

• Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

  Jon Minford;Yves Pommier;Jan Filipski;Kurt W. Kohn

  213
  Citations

• Formation and rejoining of deoxyribonucleic acid double-strand breaks induced in isolated cell nuclei by antineoplastic intercalating agents

  Yves Pommier;Ronald E. Schwartz;Kurt W. Kohn;Leonard A. Zwelling

  203
  Citations

• Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

  E. Reed;S. H. Yuspa;Leonard A Zwelling;R. F. Ozols

  202
  Citations

• A survey on data reproducibility in cancer research provides insights into our limited ability to translate findings from the laboratory to the clinic.

  Aaron Mobley;Suzanne K. Linder;Russell Braeuer;Lee M. Ellis

  202
  Citations

• Mechanism of action of cis-dichlorodiammineplatinum(II).

  Leonard A Zwelling;K. W. Kohn

  201
  Citations

• Phase I study of Topotecan, a new topoisomerase I inhibitor, in patients with refractory or relapsed acute leukemia

  HM Kantarjian;M Beran;A Ellis;L Zwelling

  197
  Citations

• Identification of a Point Mutation in the Topoisomerase II Gene from a Human Leukemia Cell Line Containing an Amsacrine-resistant Form of Topoisomerase II

  Michael Hinds;Karl Deisseroth;Karl Deisseroth;Janice Mayes;Elizabeth Altschuler

  181
  Citations

• Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage

  Yves Pommier;Jon K. Minford;Ronald E. Schwartz;Leonard A. Zwelling

  180
  Citations

• Effects of DNA intercalating agents on topoisomerase II induced DNA strand cleavage in isolated mammalian cell nuclei.

  Yves Pommier;Ronald E. Schwartz;Leonard A. Zwelling;Kurt W. Kohn

  180
  Citations

• Kinetics of Formation and Disappearance of a DNA Cross-linking Effect in Mouse Leukemia L1210 Cells Treated with cis- and trans-Diamminedichloroplatinum(II)

  Leonard A. Zwelling;Kurt W. Kohn;Warren E. Ross;Regina A. G. Ewig

  163
  Citations

• Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia

  Scott H. Kaufmann;Judith E. Karp;Richard J. Jones;Carole B. Miller

  158
  Citations

• Mutagenicity, cytotoxicity and DNA crosslinking in V79 Chinese hamster cells treated with cis- and trans-Pt(II) diamminedichloride.

  Leonard A. Zwelling;Matthews O. Bradley;Nancy A. Sharkey;Tom Anderson

  155
  Citations

• Reduced Formation of Protein-associated DNA Strand Breaks in Chinese Hamster Cells Resistant to Topoisomerase II Inhibitors

  Yves Pommier;Ronald E. Schwartz;Leonard A. Zwelling;Donna Kerrigan

  149
  Citations