World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
9554
World Ranking
18329
National Ranking
7486

Overview

Michael R. Mattern is affiliated with the National Institutes of Health in the United States. Their research portfolio spans multiple disciplines, focusing particularly on Medicine and Social Sciences.

The scientist's work crosses various subfields, including Epidemiology, Molecular Biology, Neurology, Management of Technology and Innovation, and Sociology and Political Science. This interdisciplinary approach reflects in the diversity of topics addressed in their publications.

Michael R. Mattern has contributed to the following main research topics:

  • Autophagy in Disease and Therapy
  • Ubiquitin and Proteasome Pathways
  • Parkinson's Disease Mechanisms and Treatments
  • Digital Innovation in Industries
  • Innovation, Technology, and Society
  • Vocational Education and Training
  • Water Resources Management and Optimization

Their recent publications include:

  • The Ubiquitin Proteasome System as a Therapeutic Area in Parkinson's Disease, 2023, NeuroMolecular Medicine
  • Innovationslabor Digitalisierung - Produktentwicklung mittels Design Thinking im Makerspace, 2023, Industrie 4.0 Management

Their coauthors have included:

  • Suresh Kumar
  • Matthew S. Goldberg
  • Tauseef R. Butt
  • Sebastian Bast
  • K. Scherer

Michael R. Mattern's frequent publication venues are NeuroMolecular Medicine and Industrie 4.0 Management, indicating engagement with both biomedical and technology management communities.

Best Publications

  • SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins

    Michael P Malakhov;Michael R Mattern;Oxana A Malakhova;Mark Drinker

  • SUMO fusion technology for difficult-to-express proteins

    Tauseef R. Butt;Suzanne C. Edavettal;John P. Hall;Michael R. Mattern

  • Modification of the hydroxy lactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity.

    Robert P. Hertzberg;Mary Jo Caranfa;Kenneth G. Holden;Dalia R. Jakas

  • Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

    Fred H. Drake;Glenn A. Hofmann;Henry F. Bartus;Michael R. Mattern

  • Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

    Priya Chaturvedi;Wai K Eng;Yuan Zhu;Michael R Mattern

  • Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity *

    Bin-Bing S. Zhou;Priya Chaturvedi;Kevin Spring;Shaun P. Scott

  • In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]gold(I) chloride.

    Susan J. Berners-Price;Christopher K. Mirabelli;Randall K. Johnson;Michael R. Mattern

  • The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore

    Christopher S. Stevenson;Elizabeth A. Capper;Amy K. Roshak;Brian Marquez

  • 4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo.

    Lara S. Kallander;Qing Lu;Wenfang Chen;Thaddeus Tomaszek

  • Human tumor cell strains defective in the repair of alkylation damage.

    Rufus S. Day;Chuck H.J. Ziolkowski;Dominic A. Scudiero;Sharon A. Meyer

  • Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864).

    Michael R. Mattern;Glenn A. Hofmann;Francis L. McCabe;Randall K. Johnson

  • Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

    Jon Minford;Yves Pommier;Jan Filipski;Kurt W. Kohn

  • Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells.

    Michael R. Mattern;Shau Ming Mong;Henry F. Bartus;Christopher K. Mirabelli

  • Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.

    Weinstock J;Wu J;Cao P;Kingsbury Wd

  • Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas.

    Dominic A. Scudiero;Sharon A. Meyer;Brian E. Clatterbuck;Michael R. Mattern

  • Enhanced expression and purification of membrane proteins by SUMO fusion in Escherichia coli.

    Xun Zuo;Shuisen Li;John Hall;Michael R. Mattern

  • Deubiquitinating Enzymes as Novel Anticancer Targets

    Benjamin Nicholson;Jeffrey G Marblestone;Tauseef R Butt;Michael R Mattern

  • Reduced Formation of Protein-associated DNA Strand Breaks in Chinese Hamster Cells Resistant to Topoisomerase II Inhibitors

    Yves Pommier;Ronald E. Schwartz;Leonard A. Zwelling;Donna Kerrigan

  • Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities

    Benjamin Nicholson;Craig A. Leach;Seth J. Goldenberg;Dana M. Francis

  • Dependence of mammalian DNA synthesis on DNA supercoiling. III Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid

    Michael R. Mattern;Dominic A. Scudiero

Frequent Co-Authors

Jian Wu
Jian Wu Fudan University
Leonard A. Zwelling
Leonard A. Zwelling The University of Texas MD Anderson Cancer Center
Yves Pommier
Yves Pommier National Institutes of Health
Kurt W. Kohn
Kurt W. Kohn National Institutes of Health
Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania
Dominic A. Scudiero
Dominic A. Scudiero Science Applications International Corporation (United States)
Daniel F. Veber
Daniel F. Veber GlaxoSmithKline (United Kingdom)
Taku Kambayashi
Taku Kambayashi University of Pennsylvania
Stanley T. Crooke
Stanley T. Crooke Ionis Pharmaceuticals (United States)
Ronald H. Schwartz
Ronald H. Schwartz National Institutes of Health

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